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Evaluation of domino liver transplantations in Germany

A retrospective multicenter study has been conducted to evaluate domino liver transplantations (DLTs) in Germany. The study provides insight into survival and features having an impact on the assessment of neuropathy after DLT. In addition, a neurologic follow-up program with a scheme to estimate th...

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Main Authors: Bolte, Fabian Johannes (Author) , Schmidt, Hartmut H.-J. (Author) , Becker, Thomas (Author) , Braun, Felix (Author) , Pascher, Andreas (Author) , Klempnauer, Jürgen (Author) , Schmidt, Jan (Author) , Nadalin, Silvio (Author) , Otto, Gerd (Author) , Barreiros, Ana Paula (Author)
Format: Article (Journal)
Language:English
Published: 14 May 2013
In: Transplant international
Year: 2013, Volume: 26, Issue: 7, Pages: 715-723
ISSN:1432-2277
DOI:https://doi.org/10.1111/tri.12110
Online Access:Verlag, lizenzpflichtig, Volltext: https://doi.org/https://doi.org/10.1111/tri.12110
Verlag, lizenzpflichtig, Volltext: https://onlinelibrary.wiley.com/doi/abs/10.1111/tri.12110
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Author Notes:Fabian Johannes Bolte, Hartmut H.-J. Schmidt, Thomas Becker, Felix Braun, Andreas Pascher, Jürgen Klempnauer, Jan Schmidt, Silvio Nadalin, Gerd Otto and Ana Paula Barreiros
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Summary:A retrospective multicenter study has been conducted to evaluate domino liver transplantations (DLTs) in Germany. The study provides insight into survival and features having an impact on the assessment of neuropathy after DLT. In addition, a neurologic follow-up program with a scheme to estimate the likelihood of de novo amyloidosis is presented. A series of 61 DLTs at seven transplant centers in Germany was enrolled. The mean age of domino recipients at the time of transplantation was 58 years, 46 of them being men, and 15 being women. The median follow-up was 46 months. The overall 1-, 3-, and 5-year survival of domino recipients was 81.6%, 70.8% and 68.8%, respectively. Causes of death were primarily not related to familial amyloidosis. The main indication of DLT was hepatocellular carcinoma. Two of the reported domino recipients developed symptoms and signs of de novo amyloidosis within 10 years after transplantation. A total of 30 domino graft recipients (49.18%) presented with diabetes post transplantation. In conclusion, an advanced follow-up program is crucial to evaluate the risk of transmitting familial amyloidosis by DLT and to establish more strict selection criteria for domino recipients.
Item Description:Gesehen am 01.12.2020
Physical Description:Online Resource
ISSN:1432-2277
DOI:https://doi.org/10.1111/tri.12110

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