MicroRNA-34a regulates cardiac ageing and function

A role is demonstrated for miR-34a, a microRNA that is upregulated in the ageing heart; miR-34a downregulates PNUTS, a protein that protects cardiomyocytes and telomeres, silencing of miR-34a is therefore a promising therapeutic target.

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Bibliographic Details
Main Authors:	Boon, Reinier (Author) , Iekushi, Kazuma (Author) , Lechner, Stefanie (Author) , Seeger, Timon (Author) , Fischer, Ariane (Author) , Heydt, Susanne (Author) , Kaluza, David (Author) , Tréguer, Karine (Author) , Carmona, Guillaume (Author) , Bonauer, Angelika (Author) , Horrevoets, Anton J. G. (Author) , Didier, Nathalie (Author) , Girmatsion, Zenawit (Author) , Biliczki, Peter (Author) , Ehrlich, Joachim R. (Author) , Katus, Hugo (Author) , Müller, Oliver J. (Author) , Potente, Michael (Author) , Zeiher, Andreas M. (Author) , Hermeking, Heiko (Author) , Dimmeler, Stefanie (Author)
Format:	Article (Journal) Editorial
Language:	English
Published:	20 February 2013
In:	Nature Year: 2013, Volume: 495, Issue: 7439, Pages: 107-110
ISSN:	1476-4687
DOI:	10.1038/nature11919
Online Access:	Verlag, lizenzpflichtig, Volltext: https://doi.org/10.1038/nature11919 Verlag, lizenzpflichtig, Volltext: https://www.nature.com/articles/nature11919
Author Notes:	Reinier A. Boon, Kazuma Iekushi, Stefanie Lechner, Timon Seeger, Ariane Fischer, Susanne Heydt, David Kaluza, Karine Tréguer, Guillaume Carmona, Angelika Bonauer, Anton J. G. Horrevoets, Nathalie Didier, Zenawit Girmatsion, Peter Biliczki, Joachim R. Ehrlich, Hugo A. Katus, Oliver J. Müller, Michael Potente, Andreas M. Zeiher, Heiko Hermeking & Stefanie Dimmeler

Description
Summary:	A role is demonstrated for miR-34a, a microRNA that is upregulated in the ageing heart; miR-34a downregulates PNUTS, a protein that protects cardiomyocytes and telomeres, silencing of miR-34a is therefore a promising therapeutic target.
Item Description:	Gesehen am 02.12.2020
Physical Description:	Online Resource
ISSN:	1476-4687
DOI:	10.1038/nature11919