MicroRNA-34a regulates cardiac ageing and function
A role is demonstrated for miR-34a, a microRNA that is upregulated in the ageing heart; miR-34a downregulates PNUTS, a protein that protects cardiomyocytes and telomeres, silencing of miR-34a is therefore a promising therapeutic target.
Gespeichert in:
| Hauptverfasser: | , , , , , , , , , , , , , , , , , , , , |
|---|---|
| Dokumenttyp: | Article (Journal) Editorial |
| Sprache: | Englisch |
| Veröffentlicht: |
20 February 2013
|
| In: |
Nature
Year: 2013, Jahrgang: 495, Heft: 7439, Pages: 107-110 |
| ISSN: | 1476-4687 |
| DOI: | 10.1038/nature11919 |
| Online-Zugang: | Verlag, lizenzpflichtig, Volltext: https://doi.org/10.1038/nature11919 Verlag, lizenzpflichtig, Volltext: https://www.nature.com/articles/nature11919 |
| Verfasserangaben: | Reinier A. Boon, Kazuma Iekushi, Stefanie Lechner, Timon Seeger, Ariane Fischer, Susanne Heydt, David Kaluza, Karine Tréguer, Guillaume Carmona, Angelika Bonauer, Anton J. G. Horrevoets, Nathalie Didier, Zenawit Girmatsion, Peter Biliczki, Joachim R. Ehrlich, Hugo A. Katus, Oliver J. Müller, Michael Potente, Andreas M. Zeiher, Heiko Hermeking & Stefanie Dimmeler |
| Zusammenfassung: | A role is demonstrated for miR-34a, a microRNA that is upregulated in the ageing heart; miR-34a downregulates PNUTS, a protein that protects cardiomyocytes and telomeres, silencing of miR-34a is therefore a promising therapeutic target. |
|---|---|
| Beschreibung: | Gesehen am 02.12.2020 |
| Beschreibung: | Online Resource |
| ISSN: | 1476-4687 |
| DOI: | 10.1038/nature11919 |