Intrinsic breast cancer subtypes defined by estrogen receptor signalling: prognostic relevance of progesterone receptor loss
The majority of luminal type breast carcinomas are slowly growing tumors with an overall favorable prognosis. However, a proportion of cases (luminal B tumors) are characterized by coactivation of growth factor receptors or non-canonical ER signaling and a poorer clinical outcome. The aim of our stu...
Gespeichert in:
| Hauptverfasser: | , , , , , , , |
|---|---|
| Dokumenttyp: | Article (Journal) |
| Sprache: | Englisch |
| Veröffentlicht: |
5 April 2013
|
| In: |
Modern pathology
Year: 2013, Jahrgang: 26, Heft: 9, Pages: 1161-1171 |
| ISSN: | 1530-0285 |
| DOI: | 10.1038/modpathol.2013.60 |
| Online-Zugang: | Verlag, lizenzpflichtig, Volltext: https://doi.org/10.1038/modpathol.2013.60 Verlag, lizenzpflichtig, Volltext: https://www.nature.com/articles/modpathol201360 
|
| Verfasserangaben: | Lisa Braun, Friederike Mietzsch, Petra Seibold, Andreas Schneeweiss, Peter Schirmacher, Jenny Chang-Claude, Hans Peter Sinn and Sebastian Aulmann |
MARC
| LEADER | 00000caa a2200000 c 4500 | ||
|---|---|---|---|
| 001 | 1741963214 | ||
| 003 | DE-627 | ||
| 005 | 20220819043153.0 | ||
| 007 | cr uuu---uuuuu | ||
| 008 | 201203s2013 xx |||||o 00| ||eng c | ||
| 024 | 7 | |a 10.1038/modpathol.2013.60 |2 doi | |
| 035 | |a (DE-627)1741963214 | ||
| 035 | |a (DE-599)KXP1741963214 | ||
| 035 | |a (OCoLC)1341383125 | ||
| 040 | |a DE-627 |b ger |c DE-627 |e rda | ||
| 041 | |a eng | ||
| 084 | |a 33 |2 sdnb | ||
| 100 | 1 | |a Braun, Lisa |d 1984- |e VerfasserIn |0 (DE-588)1096249723 |0 (DE-627)856678619 |0 (DE-576)467957819 |4 aut | |
| 245 | 1 | 0 | |a Intrinsic breast cancer subtypes defined by estrogen receptor signalling |b prognostic relevance of progesterone receptor loss |c Lisa Braun, Friederike Mietzsch, Petra Seibold, Andreas Schneeweiss, Peter Schirmacher, Jenny Chang-Claude, Hans Peter Sinn and Sebastian Aulmann |
| 264 | 1 | |c 5 April 2013 | |
| 300 | |a 11 | ||
| 336 | |a Text |b txt |2 rdacontent | ||
| 337 | |a Computermedien |b c |2 rdamedia | ||
| 338 | |a Online-Ressource |b cr |2 rdacarrier | ||
| 500 | |a Gesehen am 03.12.2020 | ||
| 520 | |a The majority of luminal type breast carcinomas are slowly growing tumors with an overall favorable prognosis. However, a proportion of cases (luminal B tumors) are characterized by coactivation of growth factor receptors or non-canonical ER signaling and a poorer clinical outcome. The aim of our study was to evaluate whether the expression of proteins that are part of the ER signaling network may be used to distinguish low-risk from high-risk luminal tumors. Unsupervised hierarchical clustering of a set of proteins either involved in estrogen receptor signaling or associated with resistance to endocrine therapy was performed in a series of 443 postmenopausal breast carcinomas. Using this approach, we were able to reproduce the established classification with two distinct groups of luminal (estrogen receptor positive) tumors, one group of HER2-associated tumors and a group of triple-negative tumors. However, neither proliferation nor the expression of one or more of the ER-co-factors or resistance-associated factors, but PR-expression was identified as the most important stratifier distinguishing between the two luminal groups. In fact, not only the four identified clusters were shown to be significantly associated with patient outcome, PR-expression alone or in combination with Ki-67-stains stratified ER-positive tumors into a low-risk and a high-risk group. Our data indicate that defining luminal B tumors by the presence of high-risk criteria (loss of PR-expression or increased proliferation) provides a robust and highly significant stratification of ER-positive breast carcinomas into luminal A and B. | ||
| 700 | 1 | |a Mietzsch, Friederike |e VerfasserIn |4 aut | |
| 700 | 1 | |a Seibold, Petra Beate |d 1981- |e VerfasserIn |0 (DE-588)1022470523 |0 (DE-627)71698962X |0 (DE-576)362814635 |4 aut | |
| 700 | 1 | |a Schneeweiss, Andreas |d 1961- |e VerfasserIn |0 (DE-588)109972554 |0 (DE-627)632849630 |0 (DE-576)327251859 |4 aut | |
| 700 | 1 | |a Schirmacher, Peter |d 1961- |e VerfasserIn |0 (DE-588)1020440112 |0 (DE-627)691221197 |0 (DE-576)360427448 |4 aut | |
| 700 | 1 | |a Chang-Claude, Jenny |e VerfasserIn |0 (DE-588)1049304993 |0 (DE-627)781626188 |0 (DE-576)168344475 |4 aut | |
| 700 | 1 | |a Sinn, Peter |d 1957- |e VerfasserIn |0 (DE-588)1022590944 |0 (DE-627)717004783 |0 (DE-576)365646342 |4 aut | |
| 700 | 1 | |a Aulmann, Sebastian |d 1973- |e VerfasserIn |0 (DE-588)124520197 |0 (DE-627)363393021 |0 (DE-576)294211519 |4 aut | |
| 773 | 0 | 8 | |i Enthalten in |t Modern pathology |d London : Nature Publishing Group, 1988 |g 26(2013), 9, Seite 1161-1171 |h Online-Ressource |w (DE-627)326643419 |w (DE-600)2041318-X |w (DE-576)283165553 |x 1530-0285 |7 nnas |a Intrinsic breast cancer subtypes defined by estrogen receptor signalling prognostic relevance of progesterone receptor loss |
| 773 | 1 | 8 | |g volume:26 |g year:2013 |g number:9 |g pages:1161-1171 |g extent:11 |a Intrinsic breast cancer subtypes defined by estrogen receptor signalling prognostic relevance of progesterone receptor loss |
| 856 | 4 | 0 | |u https://doi.org/10.1038/modpathol.2013.60 |x Verlag |x Resolving-System |z lizenzpflichtig |3 Volltext |
| 856 | 4 | 0 | |u https://www.nature.com/articles/modpathol201360 |x Verlag |z lizenzpflichtig |3 Volltext |
| 951 | |a AR | ||
| 992 | |a 20201203 | ||
| 993 | |a Article | ||
| 994 | |a 2013 | ||
| 998 | |g 124520197 |a Aulmann, Sebastian |m 124520197:Aulmann, Sebastian |d 50000 |e 50000PA124520197 |k 0/50000/ |p 8 |y j | ||
| 998 | |g 1022590944 |a Sinn, Peter |m 1022590944:Sinn, Peter |d 910000 |d 912000 |d 50000 |e 910000PS1022590944 |e 912000PS1022590944 |e 50000PS1022590944 |k 0/910000/ |k 1/910000/912000/ |k 0/50000/ |p 7 | ||
| 998 | |g 1049304993 |a Chang-Claude, Jenny |m 1049304993:Chang-Claude, Jenny |d 50000 |e 50000PC1049304993 |k 0/50000/ |p 6 | ||
| 998 | |g 1020440112 |a Schirmacher, Peter |m 1020440112:Schirmacher, Peter |d 910000 |d 912000 |d 50000 |e 910000PS1020440112 |e 912000PS1020440112 |e 50000PS1020440112 |k 0/910000/ |k 1/910000/912000/ |k 0/50000/ |p 5 | ||
| 998 | |g 109972554 |a Schneeweiss, Andreas |m 109972554:Schneeweiss, Andreas |d 910000 |d 910400 |e 910000PS109972554 |e 910400PS109972554 |k 0/910000/ |k 1/910000/910400/ |p 4 | ||
| 998 | |g 1022470523 |a Seibold, Petra Beate |m 1022470523:Seibold, Petra Beate |p 3 | ||
| 998 | |g 1096249723 |a Braun, Lisa |m 1096249723:Braun, Lisa |d 700000 |d 801000 |e 700000PB1096249723 |e 801000PB1096249723 |k 0/700000/ |k 1/700000/801000/ |p 1 |x j | ||
| 999 | |a KXP-PPN1741963214 |e 3816743064 | ||
| BIB | |a Y | ||
| SER | |a journal | ||
| JSO | |a {"type":{"bibl":"article-journal","media":"Online-Ressource"},"origin":[{"dateIssuedKey":"2013","dateIssuedDisp":"5 April 2013"}],"note":["Gesehen am 03.12.2020"],"title":[{"subtitle":"prognostic relevance of progesterone receptor loss","title_sort":"Intrinsic breast cancer subtypes defined by estrogen receptor signalling","title":"Intrinsic breast cancer subtypes defined by estrogen receptor signalling"}],"id":{"doi":["10.1038/modpathol.2013.60"],"eki":["1741963214"]},"name":{"displayForm":["Lisa Braun, Friederike Mietzsch, Petra Seibold, Andreas Schneeweiss, Peter Schirmacher, Jenny Chang-Claude, Hans Peter Sinn and Sebastian Aulmann"]},"physDesc":[{"extent":"11 S."}],"relHost":[{"language":["eng"],"part":{"volume":"26","extent":"11","issue":"9","text":"26(2013), 9, Seite 1161-1171","year":"2013","pages":"1161-1171"},"origin":[{"dateIssuedKey":"1988","publisher":"Nature Publishing Group ; Lippincott Williams & Wilkins ; Ovid","dateIssuedDisp":"1988-","publisherPlace":"London ; Hagerstown, Md. ; [Erscheinungsort nicht ermittelbar]"}],"note":["Gesehen am 05.01.23","Fortsetzung der Druck-Ausgabe"],"pubHistory":["1.1988 -"],"title":[{"title":"Modern pathology","subtitle":"an official journal of the United States and Canadian Academy of Pathology (USCAP)","title_sort":"Modern pathology"}],"disp":"Intrinsic breast cancer subtypes defined by estrogen receptor signalling prognostic relevance of progesterone receptor lossModern pathology","type":{"media":"Online-Ressource","bibl":"periodical"},"recId":"326643419","physDesc":[{"extent":"Online-Ressource"}],"id":{"zdb":["2041318-X"],"issn":["1530-0285"],"eki":["326643419"]}}],"recId":"1741963214","person":[{"role":"aut","given":"Lisa","family":"Braun","display":"Braun, Lisa"},{"given":"Friederike","role":"aut","display":"Mietzsch, Friederike","family":"Mietzsch"},{"display":"Seibold, Petra Beate","family":"Seibold","given":"Petra Beate","role":"aut"},{"role":"aut","given":"Andreas","family":"Schneeweiss","display":"Schneeweiss, Andreas"},{"given":"Peter","role":"aut","display":"Schirmacher, Peter","family":"Schirmacher"},{"role":"aut","given":"Jenny","display":"Chang-Claude, Jenny","family":"Chang-Claude"},{"role":"aut","given":"Peter","family":"Sinn","display":"Sinn, Peter"},{"family":"Aulmann","display":"Aulmann, Sebastian","role":"aut","given":"Sebastian"}],"language":["eng"]} | ||
| SRT | |a BRAUNLISAMINTRINSICB5201 | ||