Immunohistological expression of SOX-10 in triple-negative breast cancer: a descriptive analysis of 113 samples
Background: SRY-related HMG-box 10 (SOX-10) is commonly expressed in triple negative breast cancer (TNBC). However, data on the biological significance of SOX-10 expression is limited. Therefore, we investigated immunhistological SOX-10 expression in TNBC and correlated the results with genetic alte...
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| Hauptverfasser: | , , , , , |
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| Dokumenttyp: | Article (Journal) |
| Sprache: | Englisch |
| Veröffentlicht: |
3 September 2020
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| In: |
International journal of molecular sciences
Year: 2020, Jahrgang: 21, Heft: 17 |
| ISSN: | 1422-0067 |
| DOI: | 10.3390/ijms21176407 |
| Online-Zugang: | Verlag, lizenzpflichtig, Volltext: https://doi.org/10.3390/ijms21176407 Verlag, lizenzpflichtig, Volltext: https://www.mdpi.com/1422-0067/21/17/6407 
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| Verfasserangaben: | Katharina Kriegsmann, Christa Flechtenmacher, Jörg Heil, Jörg Kriegsmann, Gunhild Mechtersheimer, Sebastian Aulmann, Wilko Weichert, Hans-Peter Sinn and Mark Kriegsmann |
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| 245 | 1 | 0 | |a Immunohistological expression of SOX-10 in triple-negative breast cancer |b a descriptive analysis of 113 samples |c Katharina Kriegsmann, Christa Flechtenmacher, Jörg Heil, Jörg Kriegsmann, Gunhild Mechtersheimer, Sebastian Aulmann, Wilko Weichert, Hans-Peter Sinn and Mark Kriegsmann |
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| 520 | |a Background: SRY-related HMG-box 10 (SOX-10) is commonly expressed in triple negative breast cancer (TNBC). However, data on the biological significance of SOX-10 expression is limited. Therefore, we investigated immunhistological SOX-10 expression in TNBC and correlated the results with genetic alterations and clinical data. Methods: A tissue microarray including 113 TNBC cases was stained by SOX-10. Immunohistological data of AR, BCL2, CD117, p53 and Vimentin was available from a previous study. Semiconductor-based panel sequencing data including commonly altered breast cancer genes was also available from a previous investigation. SOX-10 expression was correlated with clinicopathological, immunohistochemical and genetic data. Results: SOX-10 was significantly associated with CD117 and Vimentin, but not with AR expression. An association of SOX-10 with BCL2, EGFR or p53 staining was not observed. SOX-10-positive tumors harbored more often TP53 mutations but less frequent mutations of PIK3CA or alterations of the PIK3K pathway. SOX-10 expression had no prognostic impact either on disease-free, distant disease-free, or overall survival. Conclusions: While there might be a value of SOX-10 as a differential diagnostic marker to identify metastases of TNBC, its biological role remains to be investigated. | ||
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