Adipose tissue properties in tumor-bearing breasts
The tissue stroma plays a major role in tumors’ natural history. Important programs for tumor progression such as epithelial-mesenchymal transition are not activated as cell-autonomous processes but under the conditions of cross talk between tumor and stroma. Adipose tissue is a major component of b...
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| Hauptverfasser: | , , , , , , , , , , , , , , , , |
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| Dokumenttyp: | Article (Journal) |
| Sprache: | Englisch |
| Veröffentlicht: |
21 August 2020
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| In: |
Frontiers in oncology
Year: 2020, Jahrgang: 10 |
| ISSN: | 2234-943X |
| DOI: | 10.3389/fonc.2020.01506 |
| Online-Zugang: | Verlag, lizenzpflichtig, Volltext: https://doi.org/10.3389/fonc.2020.01506 Verlag, LF, Volltext: https://www.frontiersin.org/articles/10.3389/fonc.2020.01506/full Verlag, LF, Volltext: https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7472783 
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| Verfasserangaben: | Isabelle Miran, Dominique Scherer, Pauline Ostyn, Chafika Mazouni, Françoise Drusch, Marine Bernard, Emilie Louvet, Julien Adam, Marie-Christine Mathieu, Mariam Haffa, Jean-Philippe Antignac, Bruno Le Bizec, Philippe Vielh, Philippe Dessen, Hervé Perdry, Suzette Delaloge, Jean Feunteun |
MARC
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| 245 | 1 | 0 | |a Adipose tissue properties in tumor-bearing breasts |c Isabelle Miran, Dominique Scherer, Pauline Ostyn, Chafika Mazouni, Françoise Drusch, Marine Bernard, Emilie Louvet, Julien Adam, Marie-Christine Mathieu, Mariam Haffa, Jean-Philippe Antignac, Bruno Le Bizec, Philippe Vielh, Philippe Dessen, Hervé Perdry, Suzette Delaloge, Jean Feunteun |
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| 520 | |a The tissue stroma plays a major role in tumors’ natural history. Important programs for tumor progression such as epithelial-mesenchymal transition are not activated as cell-autonomous processes but under the conditions of cross talk between tumor and stroma. Adipose tissue is a major component of breast stroma. This study compares breast adipose tissues in women with breast tumors to those in healthy women with the ultimate aim of defining a signature that could be translated into biomarkers for cancer risk. In tumor-bearing breasts, we sampled adipose tissues adjacent to, or distant from the tumor. Parameters studied included: adipocytes size and density, immune cell infiltration, vascularization, secretome and gene expression. Adipose tissues from tumor-bearing breasts, whether adjacent to or distant from the tumor, do not differ from each other by any of these parameters. By contrast, adipose tissues from tumor-bearing breasts have the capacity to secrete twice as much interleukin 8 (IL-8) than those from tumor-free breasts and differentially express a set of 200 genes of which many belong to inflammation and integrin signaling pathways. These observations show that adipose tissues from tumor-bearing breasts display unique constitutive properties. We propose that these properties contribute to the permissiveness of the breast tissue to tumor growth as a non-cell autonomous process. | ||
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