Association between the risk for lung adenocarcinoma and a (−4) G-to-A polymorphism in the XPA gene
Polymorphisms of genes coding for DNA repair can affect lung cancer risk. A common single nucleotide (−4) G-to-A polymorphism was identified previously in the 5′ untranslated region of the XPA gene. In a case-control study in European Caucasians, the influence of this polymorphism on primary lung ca...
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| Hauptverfasser: | , , , , , , , , , |
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| Dokumenttyp: | Article (Journal) |
| Sprache: | Englisch |
| Veröffentlicht: |
December 2004
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| In: |
Cancer epidemiology, biomarkers & prevention
Year: 2004, Jahrgang: 13, Heft: 12, Pages: 2242-2246 |
| ISSN: | 1538-7755 |
| Online-Zugang: | Verlag, Volltext: https://cebp.aacrjournals.org/content/13/12/2242
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| Verfasserangaben: | Dorota Butkiewicz, Odilia Popanda, Angela Risch, Lutz Edler, Hendrik Dienemann, Volker Schulz, Klaus Kayser, Peter Drings, Helmut Bartsch, and Peter Schmezer |
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| 245 | 1 | 0 | |a Association between the risk for lung adenocarcinoma and a (−4) G-to-A polymorphism in the XPA gene |c Dorota Butkiewicz, Odilia Popanda, Angela Risch, Lutz Edler, Hendrik Dienemann, Volker Schulz, Klaus Kayser, Peter Drings, Helmut Bartsch, and Peter Schmezer |
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| 520 | |a Polymorphisms of genes coding for DNA repair can affect lung cancer risk. A common single nucleotide (−4) G-to-A polymorphism was identified previously in the 5′ untranslated region of the XPA gene. In a case-control study in European Caucasians, the influence of this polymorphism on primary lung cancer risk overall and according to histologic subtypes was investigated. Four hundred sixty-three lung cancer cases (including 204 adenocarcinoma and 212 squamous cell carcinoma) and 460 tumor-free hospital controls were investigated using PCR amplification and melting point analysis of sequence-specific hybridization probes. Odds ratios (OR) were calculated by multiple logistic regression analysis adjusting for age, gender, smoking habits, and occupational exposure and showed a slightly enhanced risk for all lung cancer cases as well as for squamous cell carcinoma and adenocarcinoma cases. Gene-environment interactions were analyzed with respect to smoking and occupational exposure. A nearly 3-fold increased risk for adenocarcinoma associated with the XPA AA genotype was observed for occupationally exposed individuals (OR, 2.95; 95% confidence interval, 1.42-6.14) and for heavy smokers (OR, 2.52; 95% confidence interval, 1.17-5.42). No genotype-dependent increase in OR was found for nonexposed individuals or those smoking <20 pack-years. The significant effect of the XPA polymorphism in heavy smokers and occupationally exposed individuals suggests an important gene-environment interaction for the XPA gene. The underlying mechanisms as to why AA homozygotes are predisposed to lung adenocarcinoma and which specific carcinogens are involved remains to be determined. | ||
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