Inhibition of endothelial cell functions by novel potential cancer chemopreventive agents
Endothelial cells (EC) play a major role in tumor-induced neovascularization and bridge the gap between a microtumor and growth factors such as nutrients and oxygen supply required for expansion. Immortalized human microvascular endothelial cells (HMEC-1) were utilized to assess anti-endothelial eff...
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| Main Authors: | , , |
|---|---|
| Format: | Article (Journal) |
| Language: | English |
| Published: |
22 October 2004
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| In: |
Biochemical and biophysical research communications
Year: 2004, Volume: 325, Issue: 1, Pages: 287-295 |
| ISSN: | 1090-2104 |
| DOI: | 10.1016/j.bbrc.2004.10.032 |
| Online Access: | Verlag, Volltext: https://doi.org/10.1016/j.bbrc.2004.10.032 Verlag, Volltext: http://www.sciencedirect.com/science/article/pii/S0006291X04023393 
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| Author Notes: | Elisabeth Bertl, Hans Becker, Theophil Eicher, Christian Herhaus, Govind Kapadia, Helmut Bartsch, Clarissa Gerhäuser |
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| 520 | |a Endothelial cells (EC) play a major role in tumor-induced neovascularization and bridge the gap between a microtumor and growth factors such as nutrients and oxygen supply required for expansion. Immortalized human microvascular endothelial cells (HMEC-1) were utilized to assess anti-endothelial effects of 10 novel potential cancer chemopreventive compounds from various sources that we have investigated previously in a human in vitro anti-angiogenic assay. These include the monoacylphloroglucinol isoaspidinol B, 1,2,5,7-tetrahydroxy-anthraquinone, peracetylated carnosic acid (PCA), isoxanthohumol, 2,2′,4′-trimethoxychalcone, 3′-bromo-2,4-dimethoxychalcone as well as four synthetic derivatives of lunularic acid, a bibenzyl found in mosses [Int. J. Cancer Prev. 1 (2004) 47]. EC proliferation was inhibited with half-maximal inhibitory concentrations from 0.3 to 49.6μM, whereas EC migration was affected by most compounds at sub-micromolar concentrations. PCA and the bibenzyl derivative EC 1004 potently prevented differentiation of HMEC-1 into tubule-like structures. Overall, our data indicate that inhibition of endothelial cell function contributes to various extents to the chemopreventive or anti-angiogenic potential of these lead compounds. | ||
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