ANG II- and TxA2-induced mesenteric vasoconstriction in rats is mediated by separate cell signaling pathways

Studies in vitro have demonstrated that vasoconstrictor agents increase intracellular Ca2+ and activate protein kinase C (PKC) to elevate vascular tone. The aim of the present study was to determine the importance of these signaling pathways for angiotensin II (ANG II) and thromboxane A2(TxA2) in re...

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Hauptverfasser: Bauer, Johannes (VerfasserIn) , Dau, Cécile Ngoc Dung (VerfasserIn) , Cavarape, Alessandro (VerfasserIn) , Schaefer, Franz (VerfasserIn) , Ehmke, Heimo (VerfasserIn) , Parekh, Niranjan (VerfasserIn)
Dokumenttyp: Article (Journal)
Sprache:Englisch
Veröffentlicht: 1 July 1999
In: American journal of physiology. Heart and circulatory physiology
Year: 1999, Jahrgang: 277, Heft: 1, Pages: H1-H7
ISSN:1522-1539
DOI:10.1152/ajpheart.1999.277.1.H1
Online-Zugang:Resolving-System, lizenzpflichtig, Volltext: https://doi.org/10.1152/ajpheart.1999.277.1.H1
Verlag, lizenzpflichtig, Volltext: https://journals.physiology.org/doi/full/10.1152/ajpheart.1999.277.1.h1
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Verfasserangaben:Johannes Bauer, Cécile Dau, Alessandro Cavarape, Franz Schaefer, Heimo Ehmke, and Niranjan Parekh
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Zusammenfassung:Studies in vitro have demonstrated that vasoconstrictor agents increase intracellular Ca2+ and activate protein kinase C (PKC) to elevate vascular tone. The aim of the present study was to determine the importance of these signaling pathways for angiotensin II (ANG II) and thromboxane A2(TxA2) in regulating mesenteric blood flow (MBF) in vivo.
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Beschreibung:Online Resource
ISSN:1522-1539
DOI:10.1152/ajpheart.1999.277.1.H1