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Rapid hyperspectral imaging in the mid-infrared

Despite the successes of mid-infrared hyperspectral imaging in a research environment, progress in the migration of technology into the day-to-day clinical application is slow. Clinical acceptance may be improved if the spectroscopy would be faster and the infrared microscopes available at lower cos...

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Main Authors: Kröger-Lui, Niels (Author) , Egl, Alexander (Author) , Engel, Maria (Author) , Gretz, Norbert (Author) , Isensee, Katharina (Author) , Herpich, Iris (Author) , Neudecker, Sabine (Author) , Pucci, Annemarie (Author) , Schönhals, Arthur (Author) , Petrich, Wolfgang (Author)
Format: Chapter/Article Conference Paper
Language:English
Published: 4 March 2014
In: Biomedical vibrational spectroscopy VI

DOI:10.1117/12.2041988
Online Access:Verlag, lizenzpflichtig, Volltext: https://doi.org/10.1117/12.2041988
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Author Notes:N. Kröger-Lui, A. Egl, M. Engel, N. Gretz, K. Isensee, I. Herpich, S. Neudecker, A. Pucci, A. Schönhals, and W. Petrich

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520 |a Despite the successes of mid-infrared hyperspectral imaging in a research environment, progress in the migration of technology into the day-to-day clinical application is slow. Clinical acceptance may be improved if the spectroscopy would be faster and the infrared microscopes available at lower cost. Here we present first results of a fast, multi-scale mid-infrared microscopy setup which allows for the investigation of 10.6×11.7 mm2 and 2.8×3.1mm2 fields of view with a resolution of 23.0+/-3.5 μm and 9.4+/-1.8 μm, respectively. Tunable quantum cascade lasers in the wavenumber ranges of 1030-1090 cm-1 and 1160-1320 cm-1 serve as light sources. A vapor cell is used as a frequency reference during the rapid scanning. As far as the imaging is concerned, it is the high spectral power density of the quantum cascade laser which enables the use of a microbolometer array while still obtaining reasonable signal-to-noise ratios on each pixel. Hyperspectral images are taken in times which can be as low as 52s for the overall image acquisition including referencing. 
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