Recoverin as a cancer-retina antigen
In photoreceptor cells the Ca2+-binding protein recoverin controls phosphorylation of the visual receptor rhodopsin by inhibiting rhodopsin kinase (GRK-1). It can also serve as a paraneoplastic antigen in the development of retinal degeneration in some patients with cancer. The aberrant expression o...
Saved in:
| Main Authors: | , , |
|---|---|
| Format: | Article (Journal) |
| Language: | English |
| Published: |
2007
|
| In: |
Cancer immunology immunotherapy
Year: 2007, Volume: 56, Issue: 1, Pages: 110-116 |
| ISSN: | 1432-0851 |
| DOI: | 10.1007/s00262-006-0132-z |
| Online Access: | Verlag, lizenzpflichtig, Volltext: https://doi.org/10.1007/s00262-006-0132-z
|
| Author Notes: | Alexandr V. Bazhin, Dirk Schadendorf, Pavel P. Philippov, Stefan B. Eichmüller |
MARC
| LEADER | 00000caa a2200000 c 4500 | ||
|---|---|---|---|
| 001 | 1742645607 | ||
| 003 | DE-627 | ||
| 005 | 20230816132218.0 | ||
| 007 | cr uuu---uuuuu | ||
| 008 | 201211s2007 xx |||||o 00| ||eng c | ||
| 024 | 7 | |a 10.1007/s00262-006-0132-z |2 doi | |
| 035 | |a (DE-627)1742645607 | ||
| 035 | |a (DE-599)KXP1742645607 | ||
| 035 | |a (OCoLC)1341383602 | ||
| 040 | |a DE-627 |b ger |c DE-627 |e rda | ||
| 041 | |a eng | ||
| 084 | |a 33 |2 sdnb | ||
| 100 | 1 | |a Bazhin, Alexandr V. |e VerfasserIn |0 (DE-588)1025289552 |0 (DE-627)721987710 |0 (DE-576)370168046 |4 aut | |
| 245 | 1 | 0 | |a Recoverin as a cancer-retina antigen |c Alexandr V. Bazhin, Dirk Schadendorf, Pavel P. Philippov, Stefan B. Eichmüller |
| 264 | 1 | |c 2007 | |
| 300 | |a 7 | ||
| 336 | |a Text |b txt |2 rdacontent | ||
| 337 | |a Computermedien |b c |2 rdamedia | ||
| 338 | |a Online-Ressource |b cr |2 rdacarrier | ||
| 500 | |a Published: 28 January 2006 | ||
| 500 | |a Gesehen am 11.12.2020 | ||
| 520 | |a In photoreceptor cells the Ca2+-binding protein recoverin controls phosphorylation of the visual receptor rhodopsin by inhibiting rhodopsin kinase (GRK-1). It can also serve as a paraneoplastic antigen in the development of retinal degeneration in some patients with cancer. The aberrant expression of recoverin in cancer cells and the presence of autoantibodies against recoverin are essential for the occurrence of cancer-associated retinopathy, which finally results in the apoptosis of photoreceptor cells. Noteworthy in cancer patients, the aberrant recoverin expression and the appearance of autoantibodies against recoverin are more frequent than paraneoplastic syndromes. We suggest the term “cancer-retina antigens” for this kind of proteins like recoverin that are solely expressed in retina and tumor tissues and evoke antibodies and/or T cells in patients with cancer. The rare development of a paraneoplastic syndrome is possibly caused by this immune response and probably depends on further events allowing to overcome the blood-retina barrier and the immune privileged status of the retina. It is still unknown whether aberrantly expressed recoverin could have a specific function in cancer cells, though it is suggested that it can be functionally associated with G-protein-coupled receptor kinases. This paper reviews the present knowledge on paraneoplastic syndromes associated with the aberrant expression of recoverin. A possible application of recoverin as a potential target for immunotherapy of cancer is discussed. | ||
| 700 | 1 | |a Schadendorf, Dirk |d 1960- |e VerfasserIn |0 (DE-588)11142576X |0 (DE-627)499566076 |0 (DE-576)289702275 |4 aut | |
| 700 | 1 | |a Eichmüller, Stefan B. |d 1960- |e VerfasserIn |0 (DE-588)1025289226 |0 (DE-627)721986951 |0 (DE-576)37016704X |4 aut | |
| 773 | 0 | 8 | |i Enthalten in |t Cancer immunology immunotherapy |d Berlin : Springer, 1976 |g 56(2007), 1, Seite 110-116 |h Online-Ressource |w (DE-627)253390443 |w (DE-600)1458489-X |w (DE-576)072283475 |x 1432-0851 |7 nnas |a Recoverin as a cancer-retina antigen |
| 773 | 1 | 8 | |g volume:56 |g year:2007 |g number:1 |g pages:110-116 |g extent:7 |a Recoverin as a cancer-retina antigen |
| 856 | 4 | 0 | |u https://doi.org/10.1007/s00262-006-0132-z |x Verlag |x Resolving-System |z lizenzpflichtig |3 Volltext |
| 951 | |a AR | ||
| 992 | |a 20201211 | ||
| 993 | |a Article | ||
| 994 | |a 2007 | ||
| 998 | |g 1025289226 |a Eichmüller, Stefan B. |m 1025289226:Eichmüller, Stefan B. |d 140000 |d 60000 |e 140000PE1025289226 |e 60000PE1025289226 |k 0/140000/ |k 0/60000/ |p 4 |y j | ||
| 998 | |g 11142576X |a Schadendorf, Dirk |m 11142576X:Schadendorf, Dirk |d 50000 |e 50000PS11142576X |k 0/50000/ |p 2 | ||
| 998 | |g 1025289552 |a Bazhin, Alexandr V. |m 1025289552:Bazhin, Alexandr V. |d 60000 |e 60000PB1025289552 |k 0/60000/ |p 1 |x j | ||
| 999 | |a KXP-PPN1742645607 |e 3823498444 | ||
| BIB | |a Y | ||
| SER | |a journal | ||
| JSO | |a {"name":{"displayForm":["Alexandr V. Bazhin, Dirk Schadendorf, Pavel P. Philippov, Stefan B. Eichmüller"]},"id":{"eki":["1742645607"],"doi":["10.1007/s00262-006-0132-z"]},"origin":[{"dateIssuedKey":"2007","dateIssuedDisp":"2007"}],"relHost":[{"origin":[{"publisher":"Springer","dateIssuedKey":"1976","dateIssuedDisp":"1976-","publisherPlace":"Berlin ; Heidelberg"}],"id":{"eki":["253390443"],"zdb":["1458489-X"],"issn":["1432-0851"]},"physDesc":[{"extent":"Online-Ressource"}],"title":[{"title_sort":"Cancer immunology immunotherapy","subtitle":"CII","title":"Cancer immunology immunotherapy"}],"pubHistory":["1.1976 -"],"part":{"year":"2007","issue":"1","pages":"110-116","text":"56(2007), 1, Seite 110-116","volume":"56","extent":"7"},"titleAlt":[{"title":"CII"}],"disp":"Recoverin as a cancer-retina antigenCancer immunology immunotherapy","type":{"media":"Online-Ressource","bibl":"periodical"},"note":["Gesehen am 15.05.2024","Fortsetzung der Druck-Ausgabe","Ungezählte Beil. ab 52.2003: Supplement"],"recId":"253390443","language":["eng"]}],"physDesc":[{"extent":"7 S."}],"person":[{"family":"Bazhin","given":"Alexandr V.","roleDisplay":"VerfasserIn","display":"Bazhin, Alexandr V.","role":"aut"},{"role":"aut","roleDisplay":"VerfasserIn","display":"Schadendorf, Dirk","given":"Dirk","family":"Schadendorf"},{"display":"Eichmüller, Stefan B.","roleDisplay":"VerfasserIn","role":"aut","family":"Eichmüller","given":"Stefan B."}],"title":[{"title":"Recoverin as a cancer-retina antigen","title_sort":"Recoverin as a cancer-retina antigen"}],"recId":"1742645607","language":["eng"],"type":{"media":"Online-Ressource","bibl":"article-journal"},"note":["Published: 28 January 2006","Gesehen am 11.12.2020"]} | ||
| SRT | |a BAZHINALEXRECOVERINA2007 | ||