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Prevalence of vancomycin-resistant enterococci among children with end-stage renal failure

To evaluate the prevalence of colonization with vancomycin-resistant enterococcus (VRE) in end-stage renal failure (ESRF), we screened the intestinal flora from 338 pediatric ESRF patients treated in 13 pediatric nephrology units in mid-Europe. Eighty-one patients were undergoing hemodialysis, 66 we...

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Bibliographic Details
Main Authors: Baum, Heike von (Author) , Schehl, Joachim (Author) , Geiss, Heinrich K. (Author) , Schaefer, Franz (Author)
Format: Article (Journal)
Language:English
Published: 15 August 1999
In: Clinical infectious diseases
Year: 1999, Volume: 29, Issue: 4, Pages: 912-916
ISSN:1537-6591
DOI:10.1086/520455
Online Access:Resolving-System, lizenzpflichtig, Volltext: https://doi.org/10.1086/520455
Verlag, lizenzpflichtig, Volltext: https://academic.oup.com/cid/article/29/4/912/451624
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Author Notes:Heike von Baum, Joachim Schehl, Heinrich K. Geiss, Franz Schaefer, and the Mid-European Pediatric Peritoneal Dialysis Study Group
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Summary:To evaluate the prevalence of colonization with vancomycin-resistant enterococcus (VRE) in end-stage renal failure (ESRF), we screened the intestinal flora from 338 pediatric ESRF patients treated in 13 pediatric nephrology units in mid-Europe. Eighty-one patients were undergoing hemodialysis, 66 were undergoing chronic peritoneal dialysis, and 191 were transplant recipients. A total of 363 enterococcal strains were recovered from 232 patients. Twenty-seven enterococcal strains from 24 patients (7.1%) had reduced susceptibility to vancomycin (minimal inhibitory concentration [MIC], >4 μg/mL). Although two patients (0.6%) carried enterococci with high-level resistance to vancomycin (MIC, >32 μg/mL; i.e., VRE), strains of enterococcus with reduced susceptibility to vancomycin (ERSV) were recovered from the other 22 subjects. Past use of vancomycin (P = .05) and tacrolimus therapy (P = .011) were independent risk factors for ERSV or VRE carriage. Enterococcal infections occurred with a similar frequency among enterococcal carriers and noncarriers; no infections with VRE or ERSV were reported. In conclusion, the prevalence of ERSV carriage and the rate of VRE colonization among mid-European children and adolescents with ESRF currently are moderate and low, respectively.
Item Description:Participating members of the Mid-European Pediatric Peritoneal Dialysis Study Group: M. Zimmering (Berlin), U. Querfeld (Cologne, Germany), M. Böswald (Erlangen, Germany), K.E. Bonzel (Essen, Germany), D.E. Müller-Wiefel (Hamburg, Germany), O. Mehls and F. Schaefer (coordinator) (Heidelberg, Germany), J. Misselwitz (Jena, Germany), C. Greiner (Leipzig, Germany), G. Klaus (Marburg, Germany), B. Klare (Munich), E. Simkova (Prague), H.-J. Stolpe (Rostock, Germany), and M. Fischbach (Strasbourg, France)
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Physical Description:Online Resource
ISSN:1537-6591
DOI:10.1086/520455

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