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Enantioselective iron-catalyzed azidation of β-keto esters and oxindoles

The first example of Fe-catalyzed enantioselective azidations of β-keto esters and oxindoles using a readily available N3-transfer reagent is reported. A number of α-azido-β-keto esters were obtained with up to 93% ee, and this methodology also generates 3-substitued 3-azidooxindoles with high enant...

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Hauptverfasser: Deng, Qing-Hai (VerfasserIn) , Bleith, Tim Manuel (VerfasserIn) , Wadepohl, Hubert (VerfasserIn) , Gade, Lutz H. (VerfasserIn)
Dokumenttyp: Article (Journal)
Sprache:Englisch
Veröffentlicht: March 28, 2013
In: Journal of the American Chemical Society
Year: 2013, Jahrgang: 135, Heft: 14, Pages: 5356-5359
ISSN:1520-5126
DOI:10.1021/ja402082p
Online-Zugang:Verlag, lizenzpflichtig, Volltext: https://doi.org/10.1021/ja402082p
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Verfasserangaben:Qing-Hai Deng, Tim Bleith, Hubert Wadepohl, and Lutz H. Gade
Beschreibung
Zusammenfassung:The first example of Fe-catalyzed enantioselective azidations of β-keto esters and oxindoles using a readily available N3-transfer reagent is reported. A number of α-azido-β-keto esters were obtained with up to 93% ee, and this methodology also generates 3-substitued 3-azidooxindoles with high enantioselectivities (up to 94%).
Beschreibung:Gesehen am 11.12.2020
Beschreibung:Online Resource
ISSN:1520-5126
DOI:10.1021/ja402082p

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