Differences in advanced magnetic resonance imaging in MOG-IgG and AQP4-IgG seropositive neuromyelitis optica spectrum disorders: a comparative study
Aims: To explore differences in advanced brain magnetic resonance imaging (MRI) characteristics between myelin oligodendrocyte (MOG) immunoglobulin (IgG) and aquaporin-4 (AQP4) IgG seropositive (+) neuromyelitis optica spectrum disorders (NMOSD). Methods: 33 AQP4-IgG and 18 MOG-IgG seropositive NMOS...
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| Hauptverfasser: | , , , , , , , , , , |
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| Dokumenttyp: | Article (Journal) |
| Sprache: | Englisch |
| Veröffentlicht: |
30 September 2020
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| In: |
Frontiers in neurology
Year: 2020, Jahrgang: 11 |
| ISSN: | 1664-2295 |
| DOI: | 10.3389/fneur.2020.499910 |
| Online-Zugang: | Verlag, lizenzpflichtig, Volltext: https://doi.org/10.3389/fneur.2020.499910 Verlag, lizenzpflichtig, Volltext: https://www.frontiersin.org/articles/10.3389/fneur.2020.499910/full 
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| Verfasserangaben: | Felix A. Schmidt, Claudia Chien, Joseph Kuchling, Judith Bellmann-Strobl, Klemens Ruprecht, Nadja Siebert, Susanna Asseyer, Sven Jarius, Alexander U. Brandt, Michael Scheel and Friedemann Paul |
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| 245 | 1 | 0 | |a Differences in advanced magnetic resonance imaging in MOG-IgG and AQP4-IgG seropositive neuromyelitis optica spectrum disorders |b a comparative study |c Felix A. Schmidt, Claudia Chien, Joseph Kuchling, Judith Bellmann-Strobl, Klemens Ruprecht, Nadja Siebert, Susanna Asseyer, Sven Jarius, Alexander U. Brandt, Michael Scheel and Friedemann Paul |
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| 520 | |a Aims: To explore differences in advanced brain magnetic resonance imaging (MRI) characteristics between myelin oligodendrocyte (MOG) immunoglobulin (IgG) and aquaporin-4 (AQP4) IgG seropositive (+) neuromyelitis optica spectrum disorders (NMOSD). Methods: 33 AQP4-IgG and 18 MOG-IgG seropositive NMOSD patients and 61 healthy control (HC) subjects were included. All 112 participants were scanned with the same standardized MRI-protocol on a 3-Tesla MRI-scanner. Brain volume and diffusion tensor imaging (DTI) parameters were assessed. Results: MOG-IgG+ patients showed reduced parallel diffusivity within white matter tracts compared to HC whereas AQP4-IgG+ showed no significant brain parenchymal damage in DTI analysis. AQP4-IgG+ patients showed reduced whole brain volumes and reduced volumes of several deep grey matter structures compared to HC whereas MOG-IgG+ patients did not show reduced brain or deep grey matter volumes compared to HC. Conclusions: Microstructural brain parenchymal damage in MOG-IgG+ patients was more pronounced than in AQP4-IgG+ patients, compared with HC, whereas normalized brain volume reduction was more severe in AQP4-IgG+ patients. Longitudinal imaging studies are warranted to further investigate this trend in NMOSD. Our results suggest that MOG-IgG+ and AQP4-IgG+ NMOSD patients differ in cerebral MRI characteristics. Advanced MRI analysis did not help to differentiate between MOG-IgG+ and AQP4-IgG+ patients in our study. | ||
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| 700 | 1 | |a Chien, Claudia |e VerfasserIn |4 aut | |
| 700 | 1 | |a Kuchling, Joseph |e VerfasserIn |4 aut | |
| 700 | 1 | |a Bellmann-Strobl, Judith |e VerfasserIn |4 aut | |
| 700 | 1 | |a Ruprecht, Klemens |e VerfasserIn |4 aut | |
| 700 | 1 | |a Siebert, Nadja |e VerfasserIn |4 aut | |
| 700 | 1 | |a Asseyer, Susanna |e VerfasserIn |4 aut | |
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| 700 | 1 | |a Scheel, Michael |e VerfasserIn |4 aut | |
| 700 | 1 | |a Paul, Friedemann |e VerfasserIn |4 aut | |
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