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Coupling of NMDA receptors and TRPM4 guides discovery of unconventional neuroprotectants

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Interface targeting skirts excitotoxicity - Nearly all attempts to use traditional N-methyl-d-aspartate receptor (NMDAR) antagonists to treat neurodegenerative diseases have failed. This is because NMDARs are not only promoters of neuronal death but also have essential physiological roles in synapti...

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Main Authors: Yan, Jing (Author) , Bengtson, C. Peter (Author) , Buchthal, Bettina (Author) , Hertle, Anna M. (Author) , Bading, Hilmar (Author)
Format: Article (Journal) Chapter/Article
Language:English
Published: 09 Oct 2020
In: Science. First release
Year: 2020, Volume: 370, Pages: 1-9
DOI:10.1126/science.aay3302
Online Access:Verlag, lizenzpflichtig, Volltext: https://doi.org/10.1126/science.aay3302
Verlag, lizenzpflichtig, Volltext: https://science.sciencemag.org/content/370/6513/eaay3302
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Author Notes:Jing Yan, C. Peter Bengtson, Bettina Buchthal, Anna M. Hagenston, Hilmar Bading
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Coupling of NMDA receptors and TRPM4 guides discovery of unconventional neuroprotectants by Yan, Jing (Author) , Bengtson, C. Peter (Author) , Buchthal, Bettina (Author) , Hertle, Anna M. (Author) , Bading, Hilmar (Author) ,


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