The impact of MFG-E8 in chronic pancreatitis: potential for future immunotherapy?
The glycoprotein MFG-E8 mediates phagocytic clearance of apoptotic cells and influences the pathogenesis and progression of inflammatory diseases. MFG-E8 was shown to attenuate the progression of inflammation and to improve survival in septic rats. Accumulating evidence suggests an immunomodulatory...
Gespeichert in:
| Hauptverfasser: | , , , , , , , , , , |
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| Dokumenttyp: | Article (Journal) |
| Sprache: | Englisch |
| Veröffentlicht: |
16 January 2013
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| In: |
BMC gastroenterology
Year: 2013, Jahrgang: 13 |
| ISSN: | 1471-230X |
| DOI: | 10.1186/1471-230X-13-14 |
| Online-Zugang: | Verlag, lizenzpflichtig, Volltext: https://doi.org/10.1186/1471-230X-13-14 |
| Verfasserangaben: | Jan G. D’Haese, Ihsan Ekin Demir, Timo Kehl, Jannik Winckler, Nathalia A. Giese, Frank Bergmann, Thomas Giese, Markus W. Büchler, Helmut Friess, Mark Hartel and Güralp O. Ceyhan |
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| 520 | |a The glycoprotein MFG-E8 mediates phagocytic clearance of apoptotic cells and influences the pathogenesis and progression of inflammatory diseases. MFG-E8 was shown to attenuate the progression of inflammation and to improve survival in septic rats. Accumulating evidence suggests an immunomodulatory link between MFG-E8 and the pro-inflammatory chemokine fractalkine, which may determine the severity of pain, fibrosis, and inflammation in chronic pancreatitis (CP). | ||
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