Cognitive differences associated with HIV serostatus and antiretroviral therapy use in a population-based sample of older adults in South Africa
Previous clinical studies have reported adverse cognitive outcomes for people living with HIV (PLWH), but there are no population-based studies comparing cognitive function between older PLWH and comparators without HIV in sub-Saharan Africa. We analyzed baseline data of 40 + years-old participants...
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| Hauptverfasser: | , , , , , , , , , , , , |
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| Dokumenttyp: | Article (Journal) |
| Sprache: | Englisch |
| Veröffentlicht: |
06 October 2020
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| In: |
Scientific reports
Year: 2020, Jahrgang: 10 |
| ISSN: | 2045-2322 |
| DOI: | 10.1038/s41598-020-73689-7 |
| Online-Zugang: | Verlag, lizenzpflichtig, Volltext: https://doi.org/10.1038/s41598-020-73689-7 Verlag, lizenzpflichtig, Volltext: https://www.nature.com/articles/s41598-020-73689-7 
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| Verfasserangaben: | Stephen B. Asiimwe, Meagan Farrell, Lindsay C. Kobayashi, Jen Manne-Goehler, Kathleen Kahn, Stephen M. Tollman, Chodziwadziwa Whiteson Kabudula, F. Xavier Gómez-Olivé, Ryan G. Wagner, Livia Montana, Lisa F. Berkman, M. Maria Glymour & Till Bärnighausen |
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| 520 | |a Previous clinical studies have reported adverse cognitive outcomes for people living with HIV (PLWH), but there are no population-based studies comparing cognitive function between older PLWH and comparators without HIV in sub-Saharan Africa. We analyzed baseline data of 40 + years-old participants in “Health and Aging in Africa: A Longitudinal Study of an INDEPTH Community in South Africa” (HAALSI) cohort. We measured cognition using a battery of conventional instruments assessing orientation, immediate- and delayed-recall, and numeracy (N = 4560), and the Oxford Cognitive Screen [OCS]-Plus, a novel instrument for low-literacy populations, assessing memory, language, visual-spatial ability, and executive functioning (N = 1997). Linear regression models comparing cognitive scores between participants with and without HIV were adjusted for sex, education, age, country of birth, father’s occupation, ever-consumed alcohol, and asset index. PLWH scored on average 0.06 (95% CI 0.01-0.12) standard deviation (SD) units higher on the conventional cognitive function measure and 0.02 (95% CI − 0.07 to 0.04) SD units lower on the OCS-Plus measure than HIV-negative participants. We found higher cognitive function scores for PLWH compared to people without HIV when using a conventional measure of cognitive function but not when using a novel instrument for low-literacy settings. | ||
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