Cover Image

Genetically predicted levels of DNA methylation biomarkers and breast cancer risk: data from 228 951 women of European descent

DNA methylation plays a critical role in breast cancer development. Previous studies have identified DNA methylation marks in white blood cells as promising biomarkers for breast cancer. However, these studies were limited by low statistical power and potential biases. Using a new methodology, we in...

Full description

Saved in:
Bibliographic Details
Main Authors: Yang, Yaohua (Author) , Wu, Lang (Author) , Shu, Xiao-Ou (Author) , Cai, Qiuyin (Author) , Shu, Xiang (Author) , Li, Bingshan (Author) , Guo, Xingyi (Author) , Ye, Fei (Author) , Michailidou, Kyriaki (Author) , Bolla, Manjeet K (Author) , Wang, Qin (Author) , Dennis, Joe (Author) , Andrulis, Irene L (Author) , Brenner, Hermann (Author) , Chenevix-Trench, Georgia (Author) , Campa, Daniele (Author) , Castelao, Jose E (Author) , Gago-Dominguez, Manuela (Author) , Dörk, Thilo (Author) , Hollestelle, Antoinette (Author) , Lophatananon, Artitaya (Author) , Muir, Kenneth (Author) , Neuhausen, Susan L (Author) , Olsson, Håkan (Author) , Sandler, Dale P (Author) , Simard, Jacques (Author) , Kraft, Peter (Author) , Pharoah, Paul D P (Author) , Easton, Douglas F (Author) , Zheng, Wei (Author) , Long, Jirong (Author)
Format: Article (Journal)
Language:English
Published: 2020
In: Journal of the National Cancer Institute
Year: 2019, Volume: 112, Issue: 3, Pages: 295-304
ISSN:1460-2105
DOI:10.1093/jnci/djz109
Online Access:Verlag, lizenzpflichtig, Volltext: https://doi.org/10.1093/jnci/djz109
Verlag, lizenzpflichtig, Volltext: https://academic.oup.com/jnci/article/112/3/295/5505447
Get full text
Author Notes:Yaohua Yang, Lang Wu, Xiao-Ou Shu, Qiuyin Cai, Xiang Shu, Bingshan Li, Xingyi Guo, Fei Ye, Kyriaki Michailidou, Manjeet K. Bolla, Qin Wang, Joe Dennis, Irene L. Andrulis, Hermann Brenner, Georgia Chenevix-Trench, Daniele Campa, Jose E. Castelao, Manuela Gago-Dominguez, Thilo Dörk, Antoinette Hollestelle, Artitaya Lophatananon, Kenneth Muir, Susan L. Neuhausen, Håkan Olsson, Dale P. Sandler, Jacques Simard, Peter Kraft, Paul D.P. Pharoah, Douglas F. Easton, Wei Zheng, Jirong Long

MARC

LEADER 00000caa a2200000 c 4500
001 1743111533
003 DE-627
005 20230427215503.0
007 cr uuu---uuuuu
008 201217r20202019xx |||||o 00| ||eng c
024 7 |a 10.1093/jnci/djz109  |2 doi 
035 |a (DE-627)1743111533 
035 |a (DE-599)KXP1743111533 
035 |a (OCoLC)1341383773 
040 |a DE-627  |b ger  |c DE-627  |e rda 
041 |a eng 
084 |a 33  |2 sdnb 
100 1 |a Yang, Yaohua  |e VerfasserIn  |0 (DE-588)1223639479  |0 (DE-627)1743112718  |4 aut 
245 1 0 |a Genetically predicted levels of DNA methylation biomarkers and breast cancer risk  |b data from 228 951 women of European descent  |c Yaohua Yang, Lang Wu, Xiao-Ou Shu, Qiuyin Cai, Xiang Shu, Bingshan Li, Xingyi Guo, Fei Ye, Kyriaki Michailidou, Manjeet K. Bolla, Qin Wang, Joe Dennis, Irene L. Andrulis, Hermann Brenner, Georgia Chenevix-Trench, Daniele Campa, Jose E. Castelao, Manuela Gago-Dominguez, Thilo Dörk, Antoinette Hollestelle, Artitaya Lophatananon, Kenneth Muir, Susan L. Neuhausen, Håkan Olsson, Dale P. Sandler, Jacques Simard, Peter Kraft, Paul D.P. Pharoah, Douglas F. Easton, Wei Zheng, Jirong Long 
264 1 |c 2020 
300 |a 10 
336 |a Text  |b txt  |2 rdacontent 
337 |a Computermedien  |b c  |2 rdamedia 
338 |a Online-Ressource  |b cr  |2 rdacarrier 
500 |a First published online May 29, 2019 
500 |a Gesehen am 17.12.2020 
520 |a DNA methylation plays a critical role in breast cancer development. Previous studies have identified DNA methylation marks in white blood cells as promising biomarkers for breast cancer. However, these studies were limited by low statistical power and potential biases. Using a new methodology, we investigated DNA methylation marks for their associations with breast cancer risk.Statistical models were built to predict levels of DNA methylation marks using genetic data and DNA methylation data from HumanMethylation450 BeadChip from the Framingham Heart Study (n = 1595). The prediction models were validated using data from the Women’s Health Initiative (n = 883). We applied these models to genomewide association study (GWAS) data of 122 977 breast cancer patients and 105 974 controls to evaluate if the genetically predicted DNA methylation levels at CpG sites (CpGs) are associated with breast cancer risk. All statistical tests were two-sided.Of the 62 938 CpG sites CpGs investigated, statistically significant associations with breast cancer risk were observed for 450 CpGs at a Bonferroni-corrected threshold of P less than 7.94 × 10-7, including 45 CpGs residing in 18 genomic regions, that have not previously been associated with breast cancer risk. Of the remaining 405 CpGs located within 500 kilobase flaking regions of 70 GWAS-identified breast cancer risk variants, the associations for 11 CpGs were independent of GWAS-identified variants. Integrative analyses of genetic, DNA methylation, and gene expression data found that 38 CpGs may affect breast cancer risk through regulating expression of 21 genes.Our new methodology can identify novel DNA methylation biomarkers for breast cancer risk and can be applied to other diseases. 
534 |c 2019 
700 1 |a Wu, Lang  |e VerfasserIn  |4 aut 
700 1 |a Shu, Xiao-Ou  |e VerfasserIn  |4 aut 
700 1 |a Cai, Qiuyin  |e VerfasserIn  |4 aut 
700 1 |a Shu, Xiang  |e VerfasserIn  |4 aut 
700 1 |a Li, Bingshan  |e VerfasserIn  |4 aut 
700 1 |a Guo, Xingyi  |e VerfasserIn  |4 aut 
700 1 |a Ye, Fei  |e VerfasserIn  |4 aut 
700 1 |a Michailidou, Kyriaki  |e VerfasserIn  |4 aut 
700 1 |a Bolla, Manjeet K  |e VerfasserIn  |4 aut 
700 1 |a Wang, Qin  |e VerfasserIn  |4 aut 
700 1 |a Dennis, Joe  |e VerfasserIn  |4 aut 
700 1 |a Andrulis, Irene L  |e VerfasserIn  |4 aut 
700 1 |a Brenner, Hermann  |e VerfasserIn  |0 (DE-588)1020516445  |0 (DE-627)691247005  |0 (DE-576)360642136  |4 aut 
700 1 |a Chenevix-Trench, Georgia  |e VerfasserIn  |4 aut 
700 1 |a Campa, Daniele  |e VerfasserIn  |4 aut 
700 1 |a Castelao, Jose E  |e VerfasserIn  |4 aut 
700 1 |a Gago-Dominguez, Manuela  |e VerfasserIn  |4 aut 
700 1 |a Dörk, Thilo  |e VerfasserIn  |4 aut 
700 1 |a Hollestelle, Antoinette  |e VerfasserIn  |4 aut 
700 1 |a Lophatananon, Artitaya  |e VerfasserIn  |4 aut 
700 1 |a Muir, Kenneth  |e VerfasserIn  |4 aut 
700 1 |a Neuhausen, Susan L  |e VerfasserIn  |4 aut 
700 1 |a Olsson, Håkan  |e VerfasserIn  |4 aut 
700 1 |a Sandler, Dale P  |e VerfasserIn  |4 aut 
700 1 |a Simard, Jacques  |e VerfasserIn  |4 aut 
700 1 |a Kraft, Peter  |e VerfasserIn  |4 aut 
700 1 |a Pharoah, Paul D P  |e VerfasserIn  |4 aut 
700 1 |a Easton, Douglas F  |e VerfasserIn  |4 aut 
700 1 |a Zheng, Wei  |e VerfasserIn  |4 aut 
700 1 |a Long, Jirong  |e VerfasserIn  |4 aut 
773 0 8 |i Enthalten in  |a National Cancer Institute  |t Journal of the National Cancer Institute  |d Oxford : Oxford Univ. Press, 1941  |g 112(2020), 3, Seite 295-304  |w (DE-627)265780713  |w (DE-600)1465951-7  |w (DE-576)074959581  |x 1460-2105  |7 nnas 
773 1 8 |g volume:112  |g year:2020  |g number:3  |g pages:295-304  |g extent:10  |a Genetically predicted levels of DNA methylation biomarkers and breast cancer risk data from 228 951 women of European descent 
856 4 0 |u https://doi.org/10.1093/jnci/djz109  |x Verlag  |x Resolving-System  |z lizenzpflichtig  |3 Volltext 
856 4 0 |u https://academic.oup.com/jnci/article/112/3/295/5505447  |x Verlag  |z lizenzpflichtig  |3 Volltext 
951 |a AR 
992 |a 20201217 
993 |a Article 
994 |a 2020 
998 |g 1020516445  |a Brenner, Hermann  |m 1020516445:Brenner, Hermann  |d 850000  |d 851600  |d 50000  |e 850000PB1020516445  |e 851600PB1020516445  |e 50000PB1020516445  |k 0/850000/  |k 1/850000/851600/  |k 0/50000/  |p 14 
999 |a KXP-PPN1743111533  |e 3826500474 
BIB |a Y 
SER |a journal 
JSO |a {"origin":[{"dateIssuedKey":"2020","dateIssuedDisp":"2020"}],"language":["eng"],"id":{"doi":["10.1093/jnci/djz109"],"eki":["1743111533"]},"type":{"media":"Online-Ressource","bibl":"article-journal"},"person":[{"display":"Yang, Yaohua","family":"Yang","given":"Yaohua","role":"aut"},{"given":"Lang","family":"Wu","display":"Wu, Lang","role":"aut"},{"given":"Xiao-Ou","display":"Shu, Xiao-Ou","family":"Shu","role":"aut"},{"given":"Qiuyin","family":"Cai","display":"Cai, Qiuyin","role":"aut"},{"role":"aut","given":"Xiang","family":"Shu","display":"Shu, Xiang"},{"given":"Bingshan","display":"Li, Bingshan","family":"Li","role":"aut"},{"display":"Guo, Xingyi","family":"Guo","given":"Xingyi","role":"aut"},{"role":"aut","given":"Fei","display":"Ye, Fei","family":"Ye"},{"given":"Kyriaki","display":"Michailidou, Kyriaki","family":"Michailidou","role":"aut"},{"role":"aut","display":"Bolla, Manjeet K","family":"Bolla","given":"Manjeet K"},{"given":"Qin","display":"Wang, Qin","family":"Wang","role":"aut"},{"given":"Joe","family":"Dennis","display":"Dennis, Joe","role":"aut"},{"role":"aut","given":"Irene L","display":"Andrulis, Irene L","family":"Andrulis"},{"role":"aut","display":"Brenner, Hermann","family":"Brenner","given":"Hermann"},{"role":"aut","given":"Georgia","display":"Chenevix-Trench, Georgia","family":"Chenevix-Trench"},{"display":"Campa, Daniele","family":"Campa","given":"Daniele","role":"aut"},{"display":"Castelao, Jose E","family":"Castelao","given":"Jose E","role":"aut"},{"role":"aut","given":"Manuela","family":"Gago-Dominguez","display":"Gago-Dominguez, Manuela"},{"given":"Thilo","display":"Dörk, Thilo","family":"Dörk","role":"aut"},{"role":"aut","display":"Hollestelle, Antoinette","family":"Hollestelle","given":"Antoinette"},{"given":"Artitaya","display":"Lophatananon, Artitaya","family":"Lophatananon","role":"aut"},{"role":"aut","given":"Kenneth","family":"Muir","display":"Muir, Kenneth"},{"role":"aut","family":"Neuhausen","display":"Neuhausen, Susan L","given":"Susan L"},{"family":"Olsson","display":"Olsson, Håkan","given":"Håkan","role":"aut"},{"role":"aut","family":"Sandler","display":"Sandler, Dale P","given":"Dale P"},{"role":"aut","display":"Simard, Jacques","family":"Simard","given":"Jacques"},{"given":"Peter","display":"Kraft, Peter","family":"Kraft","role":"aut"},{"role":"aut","given":"Paul D P","display":"Pharoah, Paul D P","family":"Pharoah"},{"role":"aut","display":"Easton, Douglas F","family":"Easton","given":"Douglas F"},{"role":"aut","given":"Wei","family":"Zheng","display":"Zheng, Wei"},{"role":"aut","given":"Jirong","display":"Long, Jirong","family":"Long"}],"title":[{"title":"Genetically predicted levels of DNA methylation biomarkers and breast cancer risk","subtitle":"data from 228 951 women of European descent","title_sort":"Genetically predicted levels of DNA methylation biomarkers and breast cancer risk"}],"physDesc":[{"extent":"10 S."}],"relHost":[{"origin":[{"publisher":"Oxford Univ. Press","dateIssuedKey":"1941","publisherPlace":"Oxford","dateIssuedDisp":"1941-"}],"language":["eng"],"corporate":[{"role":"aut","display":"National Cancer Institute"}],"type":{"bibl":"periodical","media":"Online-Ressource"},"id":{"eki":["265780713"],"zdb":["1465951-7"],"issn":["1460-2105"]},"titleAlt":[{"title":"Journal of the National Cancer Institute online"},{"title":"JNCI"}],"title":[{"subtitle":"JNCI","title":"Journal of the National Cancer Institute","title_sort":"Journal of the National Cancer Institute"}],"part":{"volume":"112","text":"112(2020), 3, Seite 295-304","pages":"295-304","extent":"10","year":"2020","issue":"3"},"disp":"National Cancer InstituteJournal of the National Cancer Institute","note":["Gesehen am 18.02.14"],"pubHistory":["1.1940/41(1941) -"],"recId":"265780713"}],"name":{"displayForm":["Yaohua Yang, Lang Wu, Xiao-Ou Shu, Qiuyin Cai, Xiang Shu, Bingshan Li, Xingyi Guo, Fei Ye, Kyriaki Michailidou, Manjeet K. Bolla, Qin Wang, Joe Dennis, Irene L. Andrulis, Hermann Brenner, Georgia Chenevix-Trench, Daniele Campa, Jose E. Castelao, Manuela Gago-Dominguez, Thilo Dörk, Antoinette Hollestelle, Artitaya Lophatananon, Kenneth Muir, Susan L. Neuhausen, Håkan Olsson, Dale P. Sandler, Jacques Simard, Peter Kraft, Paul D.P. Pharoah, Douglas F. Easton, Wei Zheng, Jirong Long"]},"recId":"1743111533","note":["First published online May 29, 2019","Gesehen am 17.12.2020"]} 
SRT |a YANGYAOHUAGENETICALL2020 

Similar Items