The impact of total body irradiation on the outcome of patients with follicular lymphoma treated with autologous stem-cell transplantation in the modern era: a retrospective study of the EBMT Lymphoma Working Party
BACKGROUND: The aim of this study was to investigate the impact of the high-dose regimen on the outcome of patients with follicular lymphoma (FL) having had autologous stem-cell transplantation (ASCT) in a recent time period. - PATIENTS: Between 1995 and 2007, 2233 patients with FL had their first A...
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| Hauptverfasser: | , , , , , , , , , , , , , , , , , , , , |
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| Dokumenttyp: | Article (Journal) |
| Sprache: | Englisch |
| Veröffentlicht: |
5 September 2014
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| In: |
Annals of oncology
Year: 2014, Jahrgang: 25, Heft: 11, Pages: 2224-2229 |
| ISSN: | 1569-8041 |
| DOI: | 10.1093/annonc/mdu440 |
| Online-Zugang: | Verlag, lizenzpflichtig, Volltext: https://doi.org/10.1093/annonc/mdu440
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| Verfasserangaben: | I. El-Najjar, A. Boumendil, J.J. Luan, R. Bouabdallah, K. Thomson, M. Mohty, P. Colombat, P. Biron, H. Tilly, M. Pfreundschuh, C. Cordonnier, A. Sureda, J.Y. Cahn, J.P. Vernant, J. Gribben, G. Cook, A.P. Haynes, A. Ferrant, H. Finel, S. Montoto, P. Dreger on behalf of the Lymphoma Working Party of the European Group for Blood and Marrow Transplantation (EBMT) |
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| 245 | 1 | 4 | |a The impact of total body irradiation on the outcome of patients with follicular lymphoma treated with autologous stem-cell transplantation in the modern era |b a retrospective study of the EBMT Lymphoma Working Party |c I. El-Najjar, A. Boumendil, J.J. Luan, R. Bouabdallah, K. Thomson, M. Mohty, P. Colombat, P. Biron, H. Tilly, M. Pfreundschuh, C. Cordonnier, A. Sureda, J.Y. Cahn, J.P. Vernant, J. Gribben, G. Cook, A.P. Haynes, A. Ferrant, H. Finel, S. Montoto, P. Dreger on behalf of the Lymphoma Working Party of the European Group for Blood and Marrow Transplantation (EBMT) |
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| 520 | |a BACKGROUND: The aim of this study was to investigate the impact of the high-dose regimen on the outcome of patients with follicular lymphoma (FL) having had autologous stem-cell transplantation (ASCT) in a recent time period. - PATIENTS: Between 1995 and 2007, 2233 patients with FL had their first ASCT with either a total body irradiation (TBI)-containing regimen or carmustin, etoposide, cytarabine and melphalan (BEAM), of which 47% were autografted in first remission. - RESULTS: After a median observation time of 73 months (interquartile range 30-107), 5- and 10-year non-relapse mortality (NRM) was similar (6% and 10% in both groups). No significant NRM differences became evident after multivariate adjustment for confounders. Secondary malignancies were observed in 9.7% and 7.9% of the patients after TBI and BEAM (P = 0.19), which were treatment-related myelodysplastic syndromes/acute myelogenous leukaemia (t-MDS/AML) in 3.4% and 2.8% (P = 0.57). The median time to t-MDS/AML was around 50 months in both groups. Because of a lower relapse incidence, TBI was associated with better event-free survival reaching statistical significance in the patients transplanted in first remission but not in those transplanted beyond first remission. - CONCLUSIONS: In patients with FL who received TBI-based ASCT after 1995 increased NRM and t-MDS/AML risks did not emerge compared with BEAM while disease control was at least equivalent. | ||
| 650 | 4 | |a Adolescent | |
| 650 | 4 | |a Adult | |
| 650 | 4 | |a Aged | |
| 650 | 4 | |a Antibodies, Monoclonal, Murine-Derived | |
| 650 | 4 | |a Antineoplastic Combined Chemotherapy Protocols | |
| 650 | 4 | |a Carmustine | |
| 650 | 4 | |a Combined Modality Therapy | |
| 650 | 4 | |a Cytarabine | |
| 650 | 4 | |a Disease-Free Survival | |
| 650 | 4 | |a Female | |
| 650 | 4 | |a follicular lymphoma | |
| 650 | 4 | |a Humans | |
| 650 | 4 | |a Lymphoma, Follicular | |
| 650 | 4 | |a Male | |
| 650 | 4 | |a Melphalan | |
| 650 | 4 | |a Middle Aged | |
| 650 | 4 | |a Neoplasm Recurrence, Local | |
| 650 | 4 | |a Podophyllotoxin | |
| 650 | 4 | |a Remission Induction | |
| 650 | 4 | |a rituximab | |
| 650 | 4 | |a Rituximab | |
| 650 | 4 | |a secondary malignancies | |
| 650 | 4 | |a Stem Cell Transplantation | |
| 650 | 4 | |a t-MDS/AML | |
| 650 | 4 | |a total body irradiation | |
| 650 | 4 | |a transplantation | |
| 650 | 4 | |a Transplantation, Autologous | |
| 650 | 4 | |a Whole-Body Irradiation | |
| 650 | 4 | |a Young Adult | |
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