IKZF1 deletion is an independent predictor of outcome in pediatric acute lymphoblastic leukemia treated according to the ALL-BFM 2000 protocol
IKZF1 gene deletions have been associated with a poor outcome in pediatric precursor B-cell acute lymphoblastic leukemia. To assess the prognostic relevance of IKZF1 deletions for patients treated on Berlin-Frankfurt-Münster Study Group trial ALL-BFM 2000, we screened 694 diagnostic acute lymphobla...
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| Main Authors: | , , , , , , , , , , , , , , , |
|---|---|
| Format: | Article (Journal) |
| Language: | English |
| Published: |
March 2013
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| In: |
Haematologica, the hematology journal
Year: 2013, Volume: 98, Issue: 3, Pages: 428-432 |
| ISSN: | 1592-8721 |
| DOI: | 10.3324/haematol.2011.056135 |
| Online Access: | Verlag, lizenzpflichtig, Volltext: https://doi.org/10.3324/haematol.2011.056135 Verlag, lizenzpflichtig, Volltext: https://haematologica.org/article/view/6596 |
| Author Notes: | Petra Dörge, Barbara Meissner, Martin Zimmermann, Anja Möricke, André Schrauder, Jean-Pierre Bouquin, Denis Schewe, Jochen Harbott, Andrea Teigler-Schlegel, Richard Ratei, Wolf-Dieter Ludwig, Rolf Koehler, Claus R. Bartram, Martin Schrappe, Martin Stanulla, and Gunnar Cario |
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| 520 | |a IKZF1 gene deletions have been associated with a poor outcome in pediatric precursor B-cell acute lymphoblastic leukemia. To assess the prognostic relevance of IKZF1 deletions for patients treated on Berlin-Frankfurt-Münster Study Group trial ALL-BFM 2000, we screened 694 diagnostic acute lymphoblastic leukemia samples by Multiplex Ligation-dependent Probe Amplification. Patients whose leukemic cells bore IKZF1 deletions had a lower 5-year event-free survival (0.69±0.05 vs. 0.85±0.01; P | ||
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