Vitamin D and dexamethasone inversely regulate parathyroid hormone-induced regulator of G protein signaling-2 expression in osteoblast-like cells
The PTH/PTHrP receptor stimulates both adenylate cyclase- and phospholipase C-dependent signaling pathways via different G proteins. The biological actions of PTH on bone are modified by steroid hormones. PTH induces expression of regulator of G protein signaling (RGS)-2, a putative preferential inh...
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| Hauptverfasser: | , , , , , |
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| Dokumenttyp: | Article (Journal) |
| Sprache: | Englisch |
| Veröffentlicht: |
01 June 2003
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| In: |
Endocrinology
Year: 2003, Jahrgang: 144, Heft: 6, Pages: 2496-2504 |
| ISSN: | 1945-7170 |
| DOI: | 10.1210/en.2002-0160 |
| Online-Zugang: | Resolving-System, lizenzpflichtig, Volltext: https://doi.org/10.1210/en.2002-0160 Verlag, lizenzpflichtig, Volltext: https://academic.oup.com/endo/article/144/6/2496/2881403 
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| Verfasserangaben: | M. Hömme, C.P. Schmitt, R. Himmele, G.F. Hoffmann, O. Mehls, and F. Schaefer |
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| 520 | |a The PTH/PTHrP receptor stimulates both adenylate cyclase- and phospholipase C-dependent signaling pathways via different G proteins. The biological actions of PTH on bone are modified by steroid hormones. PTH induces expression of regulator of G protein signaling (RGS)-2, a putative preferential inhibitor of Gq-mediated phospholipase C activation. We investigated whether steroid hormones interfere with PTH signaling by modulating PTH-induced RGS-2 expression in osteoblast-like UMR 106-01 cells. | ||
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