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Vitamin D and dexamethasone inversely regulate parathyroid hormone-induced regulator of G protein signaling-2 expression in osteoblast-like cells

The PTH/PTHrP receptor stimulates both adenylate cyclase- and phospholipase C-dependent signaling pathways via different G proteins. The biological actions of PTH on bone are modified by steroid hormones. PTH induces expression of regulator of G protein signaling (RGS)-2, a putative preferential inh...

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Bibliographische Detailangaben
Hauptverfasser: Hömme, Meike (VerfasserIn) , Schmitt, Claus P. (VerfasserIn) , Himmele, Rainer (VerfasserIn) , Hoffmann, Georg F. (VerfasserIn) , Mehls, Otto (VerfasserIn) , Schaefer, Franz (VerfasserIn)
Dokumenttyp: Article (Journal)
Sprache:Englisch
Veröffentlicht: 01 June 2003
In: Endocrinology
Year: 2003, Jahrgang: 144, Heft: 6, Pages: 2496-2504
ISSN:1945-7170
DOI:10.1210/en.2002-0160
Online-Zugang:Resolving-System, lizenzpflichtig, Volltext: https://doi.org/10.1210/en.2002-0160
Verlag, lizenzpflichtig, Volltext: https://academic.oup.com/endo/article/144/6/2496/2881403
Volltext
Verfasserangaben:M. Hömme, C.P. Schmitt, R. Himmele, G.F. Hoffmann, O. Mehls, and F. Schaefer
Beschreibung
Zusammenfassung:The PTH/PTHrP receptor stimulates both adenylate cyclase- and phospholipase C-dependent signaling pathways via different G proteins. The biological actions of PTH on bone are modified by steroid hormones. PTH induces expression of regulator of G protein signaling (RGS)-2, a putative preferential inhibitor of Gq-mediated phospholipase C activation. We investigated whether steroid hormones interfere with PTH signaling by modulating PTH-induced RGS-2 expression in osteoblast-like UMR 106-01 cells.
Beschreibung:Gesehen am 18.12.2020
Beschreibung:Online Resource
ISSN:1945-7170
DOI:10.1210/en.2002-0160

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