Expanding the indications of pancreas transplantation alone
OBJECTIVES: Total pancreatectomy (TP) is associated with postoperative endocrine and exocrine insufficiency. Especially, insulin therapy reduces quality of life and may lead to long-term complications. We review the literature with regard to the potential option of pancreas transplantation alone (PT...
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| Main Authors: | , , , , , , , , |
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| Format: | Article (Journal) |
| Language: | English |
| Published: |
2014
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| In: |
Pancreas
Year: 2014, Volume: 43, Issue: 8, Pages: 1190-1193 |
| ISSN: | 1536-4828 |
| DOI: | 10.1097/MPA.0000000000000181 |
| Online Access: | Verlag, lizenzpflichtig, Volltext: https://doi.org/10.1097/MPA.0000000000000181
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| Author Notes: | Arianeb Mehrabi, Mohammad Golriz, Fatemeh Adili-Aghdam, Mohammadreza Hafezi, Maryam Ashrafi, Christian Morath, Martin Zeier, Thilo Hackert, and Peter Schemmer |
| Summary: | OBJECTIVES: Total pancreatectomy (TP) is associated with postoperative endocrine and exocrine insufficiency. Especially, insulin therapy reduces quality of life and may lead to long-term complications. We review the literature with regard to the potential option of pancreas transplantation alone (PTA) after TP in patients with chronic pancreatitis or benign tumors. - METHODS: A MEDLINE search (1958-2013) using the terminologies pancreas transplantation, pancreas transplantation alone, total pancreatectomy, morbidity, mortality, insulin therapy, and quality of life was performed. In addition, the current book and congress publications were reviewed. - RESULTS: Total pancreatectomy after benign and borderline tumors as well as chronic pancreatitis is continuously increasing. Despite improvement of exogenous insulin therapy, more than 50% of these patients experience severe glucose control problems, which cause up to 50% long-term mortality. Pancreas transplantation alone can cure both endocrine and exocrine insufficiency and reduce the associated risks. The 3-year graft and patient survival rates after PTA are up to 73% and 100%, respectively. - CONCLUSIONS: Pancreas transplantation alone after TP in patients with pancreatitis or benign tumors improves the recipient's quality of life and reduces long-term mortality. Considering the amount of available organs and potential candidates, PTA can be a treatment option for patients after TP with chronic pancreatitis or benign tumors. |
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| Item Description: | Gesehen am 22.12.2020 |
| Physical Description: | Online Resource |
| ISSN: | 1536-4828 |
| DOI: | 10.1097/MPA.0000000000000181 |