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Investigation of the regenerative potential of necrotic mature teeth following different revascularisation protocols

This study aimed to assess the revascularisation potential of necrotic mature teeth in a dog model following different protocols. Periapical infection was induced in 54 mature premolars. Teeth were distributed into seven groups: (1) Double-antibiotic-paste/Blood clot, (2) Ciprofloxacin/collagen, (3)...

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Main Authors: Hossam Fahmy, Sarah (Author) , Hassanien, Ehab El Sayed (Author) , Nagy, Mohamed Mokhtar (Author) , Batouty, Kariem Mostafa El (Author) , Mekhemar, Mohamed (Author) , Sayed, Karim Fawzy El (Author) , Hassanein, ElHassan (Author) , Wiltfang, Jörg (Author) , Dörfer, Christof (Author)
Format: Article (Journal)
Language:English
Published: 02 August 2017
In: Australian endodontic journal
Year: 2017, Volume: 43, Issue: 2, Pages: 73-82
ISSN:1747-4477
DOI:https://doi.org/10.1111/aej.12210
Online Access:Verlag, lizenzpflichtig, Volltext: https://doi.org/https://doi.org/10.1111/aej.12210
Verlag, lizenzpflichtig, Volltext: https://onlinelibrary.wiley.com/doi/abs/10.1111/aej.12210
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Author Notes:Sarah Hossam Fahmy, Ehab El Sayed Hassanien, Mohamed Mokhtar Nagy, Kariem Mostafa El Batouty, Mohamed Mekhemar, Karim Fawzy El Sayed, El Hassan Hassanein, Jörg Wiltfang, and Christof Dörfer
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Summary:This study aimed to assess the revascularisation potential of necrotic mature teeth in a dog model following different protocols. Periapical infection was induced in 54 mature premolars. Teeth were distributed into seven groups: (1) Double-antibiotic-paste/Blood clot, (2) Ciprofloxacin/collagen, (3) Double-antibiotic-paste/Collagen, (4) Modified Tri-antibiotic-paste /collagen, (5) Ciprofloxacin/Gelfoam, (6) Double-antibiotic-paste/Gelfoam, and (7) Modified Triantibiotic- paste/Gelfoam. Positive and negative controls included infected and healthy teeth, respectively, (n = 12 roots/group). Canals were apically shaped to size 0.6 mm then disinfected for 1 month. Intra-canal bleeding was induced then scaffolds were applied for another month. Teeth and supporting bone were surgically sampled. Tissues were histologically scored and vimentin immuno-intensity was estimated. Ciprofloxacin and Double-antibiotic paste/Collagen resulted in significantly better corono-apical tissue ingrowths, vascularity, cementum formation and significantly lower inflammatory extents (P < 0.05).These groups also showed significantly higher Vimentin intensities, (P < 0.05). The applied protocols revascularised necrotic mature canals and reduced inflammation particularly in the Ciprofloxacin/collagen and Double-antibiotic-paste/collagen groups.
Item Description:Gesehen am 22.12.2020
Physical Description:Online Resource
ISSN:1747-4477
DOI:https://doi.org/10.1111/aej.12210

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