Impaired vitamin D signaling is associated with frequent development of renal cell tumor in end-stage kidney disease
Background/Aim: End-stage kidney disease is characterized by chronic inflammation and frequent development of cancer. The level of circulating vitamin D is generally low in patients with end-stage renal disease (ESRD). Experimental studies have implicated the role of dysfunctional vitamin D metaboli...
Gespeichert in:
| Hauptverfasser: | , , , , |
|---|---|
| Dokumenttyp: | Article (Journal) |
| Sprache: | Englisch |
| Veröffentlicht: |
November 2020
|
| In: |
Anticancer research
Year: 2020, Jahrgang: 40, Heft: 11, Pages: 6525-6530 |
| ISSN: | 1791-7530 |
| DOI: | 10.21873/anticanres.14676 |
| Online-Zugang: | Verlag, lizenzpflichtig, Volltext: https://doi.org/10.21873/anticanres.14676 Verlag, lizenzpflichtig, Volltext: http://ar.iiarjournals.org/content/40/11/6525 
|
| Verfasserangaben: | Janos Docs, Daniel Banyai, Tibor Flasko, Arpad Szanto, Gyula Kovacs |
MARC
| LEADER | 00000caa a2200000 c 4500 | ||
|---|---|---|---|
| 001 | 174376068X | ||
| 003 | DE-627 | ||
| 005 | 20230428024254.0 | ||
| 007 | cr uuu---uuuuu | ||
| 008 | 210104s2020 xx |||||o 00| ||eng c | ||
| 024 | 7 | |a 10.21873/anticanres.14676 |2 doi | |
| 035 | |a (DE-627)174376068X | ||
| 035 | |a (DE-599)KXP174376068X | ||
| 035 | |a (OCoLC)1341384143 | ||
| 040 | |a DE-627 |b ger |c DE-627 |e rda | ||
| 041 | |a eng | ||
| 084 | |a 33 |2 sdnb | ||
| 100 | 1 | |a Docs, Janos |e VerfasserIn |0 (DE-588)1224418514 |0 (DE-627)1743761163 |4 aut | |
| 245 | 1 | 0 | |a Impaired vitamin D signaling is associated with frequent development of renal cell tumor in end-stage kidney disease |c Janos Docs, Daniel Banyai, Tibor Flasko, Arpad Szanto, Gyula Kovacs |
| 264 | 1 | |c November 2020 | |
| 300 | |a 6 | ||
| 336 | |a Text |b txt |2 rdacontent | ||
| 337 | |a Computermedien |b c |2 rdamedia | ||
| 338 | |a Online-Ressource |b cr |2 rdacarrier | ||
| 500 | |a Gesehen am 04.01.2021 | ||
| 520 | |a Background/Aim: End-stage kidney disease is characterized by chronic inflammation and frequent development of cancer. The level of circulating vitamin D is generally low in patients with end-stage renal disease (ESRD). Experimental studies have implicated the role of dysfunctional vitamin D metabolism in tumorigenesis. Patients and Methods: We analyzed the expression of vitamin D receptor (VDR), cytochrome P450 family 27 subfamily B member 1 (CYP27B1) and cytochrome P450 family 24 subfamily A member 1 (CYP24A1), the key genes involved in vitamin D signaling, in kidneys from patients with ESRD, tissue microarrays containing ESRD-associated renal cell tumors, as well as in their precursor lesions by immunohistochemistry. Results: Kidneys from patients with ESRD showed strong structural rearrangement with only few tubules and epithelial cell groups embedded in fibrotic-inflammatory stroma. Only an estimated 1-3% of the epithelial cells showed positive staining with antibodies to VDR, CYP27B1 and CYP24A1, which contrasted with the 100%, 40-50% and 40-50% of positively stained cells, respectively, found in normal kidneys. Down-regulation of the vitamin D signaling proteins was found in patients with renal cancer, with the exception of tumors and their precursors occurring exclusively in ESRD. Conclusion: The significantly reduced activity of CYP27B1 in kidney from patients with ESRD explains the low level of circulating vitamin D. We suggest that the lack of anti-tumorigenic effect of vitamin D is a crucial factor in the frequent development of unique types of renal cell cancer in in patients with ESRD. | ||
| 650 | 4 | |a CYP24A1 | |
| 650 | 4 | |a CYP27B1 | |
| 650 | 4 | |a End-stage kidney disease | |
| 650 | 4 | |a tumor development | |
| 650 | 4 | |a VDR | |
| 700 | 1 | |a Banyai, Daniel |e VerfasserIn |0 (DE-588)1167271084 |0 (DE-627)1030938482 |0 (DE-576)511071949 |4 aut | |
| 700 | 1 | |a Flasko, Tibor |e VerfasserIn |4 aut | |
| 700 | 1 | |a Szanto, Arpad |e VerfasserIn |4 aut | |
| 700 | 1 | |a Kovacs, Gyula |e VerfasserIn |0 (DE-588)1081747579 |0 (DE-627)846587424 |0 (DE-576)454756399 |4 aut | |
| 773 | 0 | 8 | |i Enthalten in |t Anticancer research |d Kapandriti, Attiki, Greece : International Institute of Anticancer Research, 2004 |g 40(2020), 11, Seite 6525-6530 |h Online-Ressource |w (DE-627)387478493 |w (DE-600)2145376-7 |w (DE-576)358408717 |x 1791-7530 |7 nnas |a Impaired vitamin D signaling is associated with frequent development of renal cell tumor in end-stage kidney disease |
| 773 | 1 | 8 | |g volume:40 |g year:2020 |g number:11 |g pages:6525-6530 |g extent:6 |a Impaired vitamin D signaling is associated with frequent development of renal cell tumor in end-stage kidney disease |
| 856 | 4 | 0 | |u https://doi.org/10.21873/anticanres.14676 |x Verlag |x Resolving-System |z lizenzpflichtig |3 Volltext |
| 856 | 4 | 0 | |u http://ar.iiarjournals.org/content/40/11/6525 |x Verlag |z lizenzpflichtig |3 Volltext |
| 951 | |a AR | ||
| 992 | |a 20210104 | ||
| 993 | |a Article | ||
| 994 | |a 2020 | ||
| 998 | |g 1081747579 |a Kovacs, Gyula |m 1081747579:Kovacs, Gyula |d 50000 |e 50000PK1081747579 |k 0/50000/ |p 5 |y j | ||
| 999 | |a KXP-PPN174376068X |e 3829724152 | ||
| BIB | |a Y | ||
| SER | |a journal | ||
| JSO | |a {"person":[{"given":"Janos","family":"Docs","role":"aut","roleDisplay":"VerfasserIn","display":"Docs, Janos"},{"given":"Daniel","family":"Banyai","role":"aut","roleDisplay":"VerfasserIn","display":"Banyai, Daniel"},{"family":"Flasko","given":"Tibor","roleDisplay":"VerfasserIn","display":"Flasko, Tibor","role":"aut"},{"role":"aut","display":"Szanto, Arpad","roleDisplay":"VerfasserIn","given":"Arpad","family":"Szanto"},{"role":"aut","roleDisplay":"VerfasserIn","display":"Kovacs, Gyula","given":"Gyula","family":"Kovacs"}],"title":[{"title_sort":"Impaired vitamin D signaling is associated with frequent development of renal cell tumor in end-stage kidney disease","title":"Impaired vitamin D signaling is associated with frequent development of renal cell tumor in end-stage kidney disease"}],"language":["eng"],"recId":"174376068X","type":{"bibl":"article-journal","media":"Online-Ressource"},"note":["Gesehen am 04.01.2021"],"name":{"displayForm":["Janos Docs, Daniel Banyai, Tibor Flasko, Arpad Szanto, Gyula Kovacs"]},"id":{"eki":["174376068X"],"doi":["10.21873/anticanres.14676"]},"origin":[{"dateIssuedDisp":"November 2020","dateIssuedKey":"2020"}],"relHost":[{"physDesc":[{"extent":"Online-Ressource"}],"origin":[{"dateIssuedDisp":"2004-","dateIssuedKey":"2004","publisher":"International Institute of Anticancer Research","publisherPlace":"Kapandriti, Attiki, Greece"}],"id":{"eki":["387478493"],"zdb":["2145376-7"],"issn":["1791-7530"]},"name":{"displayForm":["International Institute of Anticancer Research"]},"pubHistory":["Nachgewiesen 24.2004 -"],"part":{"issue":"11","pages":"6525-6530","year":"2020","extent":"6","volume":"40","text":"40(2020), 11, Seite 6525-6530"},"note":["Gesehen am 26.02.13"],"type":{"media":"Online-Ressource","bibl":"periodical"},"disp":"Impaired vitamin D signaling is associated with frequent development of renal cell tumor in end-stage kidney diseaseAnticancer research","language":["eng"],"recId":"387478493","title":[{"subtitle":"international journal of cancer research and treatment","title":"Anticancer research","title_sort":"Anticancer research"}]}],"physDesc":[{"extent":"6 S."}]} | ||
| SRT | |a DOCSJANOSBIMPAIREDVI2020 | ||