Cover Image

BAF complexes facilitate decatenation of DNA by topoisomerase IIα

Mutations in the subunits of BAF chromatin-remodelling complexes are frequently found in human cancer; here deletion of BAF subunits or expression of mutants of the ATPase subunit BRG1 attenuates genome-wide binding of topoisomerase IIα, resulting in tangled chromosomes, anaphase bridges and G2/M ar...

Full description

Saved in:
Bibliographic Details
Main Authors: Dykhuizen, Emily C. (Author) , Hargreaves, Diana C. (Author) , Miller, Erik L. (Author) , Cui, Kairong (Author) , Korshunov, Andrey (Author) , Kool, Marcel (Author) , Pfister, Stefan (Author) , Cho, Yoon-Jae (Author) , Zhao, Keji (Author) , Crabtree, Gerald R. (Author)
Format: Article (Journal)
Language:English
Published: 22 May 2013
In: Nature
Year: 2013, Volume: 497, Issue: 7451, Pages: 624-627
ISSN:1476-4687
DOI:10.1038/nature12146
Online Access:Verlag, lizenzpflichtig, Volltext: https://doi.org/10.1038/nature12146
Verlag, lizenzpflichtig, Volltext: https://www.nature.com/articles/nature12146
Get full text
Author Notes:Emily C. Dykhuizen, Diana C. Hargreaves, Erik L. Miller, Kairong Cui, Andrey Korshunov, Marcel Kool, Stefan Pfister, Yoon-Jae Cho, Keji Zhao & Gerald R. Crabtree
Description
Summary:Mutations in the subunits of BAF chromatin-remodelling complexes are frequently found in human cancer; here deletion of BAF subunits or expression of mutants of the ATPase subunit BRG1 attenuates genome-wide binding of topoisomerase IIα, resulting in tangled chromosomes, anaphase bridges and G2/M arrest.
Item Description:Gesehen am 07.01.2021
Physical Description:Online Resource
ISSN:1476-4687
DOI:10.1038/nature12146

Similar Items