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BAF complexes facilitate decatenation of DNA by topoisomerase IIα

Mutations in the subunits of BAF chromatin-remodelling complexes are frequently found in human cancer; here deletion of BAF subunits or expression of mutants of the ATPase subunit BRG1 attenuates genome-wide binding of topoisomerase IIα, resulting in tangled chromosomes, anaphase bridges and G2/M ar...

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Hauptverfasser: Dykhuizen, Emily C. (VerfasserIn) , Hargreaves, Diana C. (VerfasserIn) , Miller, Erik L. (VerfasserIn) , Cui, Kairong (VerfasserIn) , Korshunov, Andrey (VerfasserIn) , Kool, Marcel (VerfasserIn) , Pfister, Stefan (VerfasserIn) , Cho, Yoon-Jae (VerfasserIn) , Zhao, Keji (VerfasserIn) , Crabtree, Gerald R. (VerfasserIn)
Dokumenttyp: Article (Journal)
Sprache:Englisch
Veröffentlicht: 22 May 2013
In: Nature
Year: 2013, Jahrgang: 497, Heft: 7451, Pages: 624-627
ISSN:1476-4687
DOI:10.1038/nature12146
Online-Zugang:Verlag, lizenzpflichtig, Volltext: https://doi.org/10.1038/nature12146
Verlag, lizenzpflichtig, Volltext: https://www.nature.com/articles/nature12146
Volltext
Verfasserangaben:Emily C. Dykhuizen, Diana C. Hargreaves, Erik L. Miller, Kairong Cui, Andrey Korshunov, Marcel Kool, Stefan Pfister, Yoon-Jae Cho, Keji Zhao & Gerald R. Crabtree

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