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Effect of duplex drugs linking 2′-deoxy-5-fluorouridine (5-FdU) with 3′-C-ethynylcytidine (ECyd) on hepatoblastoma cell lines

Duplex drugs are promising anticancer agents. After in vivo cleavage into active nucleoside analogues, they exert their anti-tumour activity with reduced toxicity and side effects. Here we evaluated the impact of two duplex drugs on the viability of hepatoblastoma (HB) cells lines and their toxicity...

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Bibliographic Details
Main Authors: Eicher, Carmen (Author) , Dewerth, Alexander (Author) , Ellerkamp, Verena (Author) , Fuchs, Joerg (Author) , Schott, Sarah (Author) , Armeanu-Ebinger, Sorin (Author)
Format: Article (Journal)
Language:English
Published: 2013
In: Pediatric surgery international
Year: 2012, Volume: 29, Issue: 2, Pages: 121-127
ISSN:1437-9813
DOI:10.1007/s00383-012-3192-5
Online Access:Verlag, lizenzpflichtig, Volltext: https://doi.org/10.1007/s00383-012-3192-5
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Author Notes:Carmen Eicher, Alexander Dewerth, Verena Ellerkamp, Joerg Fuchs, Sarah Schott, Sorin Armeanu-Ebinger
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Summary:Duplex drugs are promising anticancer agents. After in vivo cleavage into active nucleoside analogues, they exert their anti-tumour activity with reduced toxicity and side effects. Here we evaluated the impact of two duplex drugs on the viability of hepatoblastoma (HB) cells lines and their toxicity against human fibroblasts.
Item Description:Published online: 28 November 2012
Gesehen am 08.01.2021
Physical Description:Online Resource
ISSN:1437-9813
DOI:10.1007/s00383-012-3192-5

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