Buchumschlag

Effect of duplex drugs linking 2′-deoxy-5-fluorouridine (5-FdU) with 3′-C-ethynylcytidine (ECyd) on hepatoblastoma cell lines

Duplex drugs are promising anticancer agents. After in vivo cleavage into active nucleoside analogues, they exert their anti-tumour activity with reduced toxicity and side effects. Here we evaluated the impact of two duplex drugs on the viability of hepatoblastoma (HB) cells lines and their toxicity...

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Bibliographische Detailangaben
Hauptverfasser: Eicher, Carmen (VerfasserIn) , Dewerth, Alexander (VerfasserIn) , Ellerkamp, Verena (VerfasserIn) , Fuchs, Joerg (VerfasserIn) , Schott, Sarah (VerfasserIn) , Armeanu-Ebinger, Sorin (VerfasserIn)
Dokumenttyp: Article (Journal)
Sprache:Englisch
Veröffentlicht: 2013
In: Pediatric surgery international
Year: 2012, Jahrgang: 29, Heft: 2, Pages: 121-127
ISSN:1437-9813
DOI:10.1007/s00383-012-3192-5
Online-Zugang:Verlag, lizenzpflichtig, Volltext: https://doi.org/10.1007/s00383-012-3192-5
Volltext
Verfasserangaben:Carmen Eicher, Alexander Dewerth, Verena Ellerkamp, Joerg Fuchs, Sarah Schott, Sorin Armeanu-Ebinger
Beschreibung
Zusammenfassung:Duplex drugs are promising anticancer agents. After in vivo cleavage into active nucleoside analogues, they exert their anti-tumour activity with reduced toxicity and side effects. Here we evaluated the impact of two duplex drugs on the viability of hepatoblastoma (HB) cells lines and their toxicity against human fibroblasts.
Beschreibung:Published online: 28 November 2012
Gesehen am 08.01.2021
Beschreibung:Online Resource
ISSN:1437-9813
DOI:10.1007/s00383-012-3192-5

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