Molecular interaction of artemisinin with translationally controlled tumor protein (TCTP) of Plasmodium falciparum
Malaria causes millions of death cases per year. Since Plasmodium falciparum rapidly develops drug resistance, it is of high importance to investigate potential drug targets which may lead to novel rational therapy approaches. Here we report on the interaction of translationally controlled tumor pro...
Gespeichert in:
| Hauptverfasser: | , , , , , , , , , , |
|---|---|
| Dokumenttyp: | Article (Journal) |
| Sprache: | Englisch |
| Veröffentlicht: |
2013
|
| In: |
Biochemical pharmacology
Year: 2012, Jahrgang: 85, Heft: 1, Pages: 38-45 |
| ISSN: | 1873-2968 |
| DOI: | 10.1016/j.bcp.2012.10.006 |
| Online-Zugang: | Verlag, lizenzpflichtig, Volltext: https://doi.org/10.1016/j.bcp.2012.10.006 Verlag, lizenzpflichtig, Volltext: http://www.sciencedirect.com/science/article/pii/S0006295212006788 
|
| Verfasserangaben: | Tolga Eichhorn, Dominic Winter, Berthold Büchele, Natalie Dirdjaja, Martin Frank, Wolf-Dieter Lehmann, Rolf Mertens, R. Luise Krauth-Siegel, Thomas Simmet, Joachim Granzin, Thomas Efferth |
MARC
| LEADER | 00000caa a2200000 c 4500 | ||
|---|---|---|---|
| 001 | 1744271550 | ||
| 003 | DE-627 | ||
| 005 | 20230428055607.0 | ||
| 007 | cr uuu---uuuuu | ||
| 008 | 210108r20132012xx |||||o 00| ||eng c | ||
| 024 | 7 | |a 10.1016/j.bcp.2012.10.006 |2 doi | |
| 035 | |a (DE-627)1744271550 | ||
| 035 | |a (DE-599)KXP1744271550 | ||
| 035 | |a (OCoLC)1341384302 | ||
| 040 | |a DE-627 |b ger |c DE-627 |e rda | ||
| 041 | |a eng | ||
| 084 | |a 33 |2 sdnb | ||
| 100 | 1 | |a Eichhorn, Tolga |e VerfasserIn |0 (DE-588)1013170261 |0 (DE-627)663816157 |0 (DE-576)346649714 |4 aut | |
| 245 | 1 | 0 | |a Molecular interaction of artemisinin with translationally controlled tumor protein (TCTP) of Plasmodium falciparum |c Tolga Eichhorn, Dominic Winter, Berthold Büchele, Natalie Dirdjaja, Martin Frank, Wolf-Dieter Lehmann, Rolf Mertens, R. Luise Krauth-Siegel, Thomas Simmet, Joachim Granzin, Thomas Efferth |
| 264 | 1 | |c 2013 | |
| 300 | |a 8 | ||
| 336 | |a Text |b txt |2 rdacontent | ||
| 337 | |a Computermedien |b c |2 rdamedia | ||
| 338 | |a Online-Ressource |b cr |2 rdacarrier | ||
| 500 | |a Available online 17 October 2012 | ||
| 500 | |a Gesehen am 08.01.2021 | ||
| 520 | |a Malaria causes millions of death cases per year. Since Plasmodium falciparum rapidly develops drug resistance, it is of high importance to investigate potential drug targets which may lead to novel rational therapy approaches. Here we report on the interaction of translationally controlled tumor protein of P. falciparum (PfTCTP) with the anti-malarial drug artemisinin. Furthermore, we investigated the crystal structure of PfTCTP. Using mass spectrometry, bioinformatic approaches and surface plasmon resonance spectroscopy, we identified novel binding sites of artemisinin which are in direct neighborhood to amino acids 19-46, 108-134 and 140-163. The regions covered by these residues are known to be functionally important for TCTP function. We conclude that interaction of artemisinin with TCTP may be at least in part explain the antimalarial activity of artemisinin. | ||
| 534 | |c 2012 | ||
| 650 | 4 | |a Artemisinin | |
| 650 | 4 | |a Translationally controlled tumor protein | |
| 700 | 1 | |a Winter, Dominic |e VerfasserIn |0 (DE-588)137463863 |0 (DE-627)695826891 |0 (DE-576)301398968 |4 aut | |
| 700 | 1 | |a Büchele, Berthold |e VerfasserIn |4 aut | |
| 700 | 1 | |a Dirdjaja, Natalie |e VerfasserIn |0 (DE-588)1100399550 |0 (DE-627)859361314 |0 (DE-576)469692405 |4 aut | |
| 700 | 1 | |a Frank, Martin |e VerfasserIn |4 aut | |
| 700 | 1 | |a Lehmann, Wolf-Dieter |d 1948- |e VerfasserIn |0 (DE-588)1119825083 |0 (DE-627)872907716 |0 (DE-576)174059973 |4 aut | |
| 700 | 1 | |a Mertens, Rolf |e VerfasserIn |4 aut | |
| 700 | 1 | |a Krauth-Siegel, Renate |e VerfasserIn |0 (DE-588)1050022335 |0 (DE-627)783217390 |0 (DE-576)404300200 |4 aut | |
| 700 | 1 | |a Simmet, Thomas |e VerfasserIn |4 aut | |
| 700 | 1 | |a Granzin, Joachim |e VerfasserIn |4 aut | |
| 700 | 1 | |a Efferth, Thomas |d 1960- |e VerfasserIn |0 (DE-588)112533116 |0 (DE-627)527709158 |0 (DE-576)167480634 |4 aut | |
| 773 | 0 | 8 | |i Enthalten in |t Biochemical pharmacology |d Amsterdam [u.a.] : Elsevier Science, 1958 |g 85(2013), 1, Seite 38-45 |h Online-Ressource |w (DE-627)30631777X |w (DE-600)1496199-4 |w (DE-576)081952929 |x 1873-2968 |7 nnas |a Molecular interaction of artemisinin with translationally controlled tumor protein (TCTP) of Plasmodium falciparum |
| 773 | 1 | 8 | |g volume:85 |g year:2013 |g number:1 |g pages:38-45 |g extent:8 |a Molecular interaction of artemisinin with translationally controlled tumor protein (TCTP) of Plasmodium falciparum |
| 856 | 4 | 0 | |u https://doi.org/10.1016/j.bcp.2012.10.006 |x Verlag |x Resolving-System |z lizenzpflichtig |3 Volltext |
| 856 | 4 | 0 | |u http://www.sciencedirect.com/science/article/pii/S0006295212006788 |x Verlag |z lizenzpflichtig |3 Volltext |
| 951 | |a AR | ||
| 992 | |a 20210108 | ||
| 993 | |a Article | ||
| 994 | |a 2013 | ||
| 998 | |g 1050022335 |a Krauth-Siegel, Renate |m 1050022335:Krauth-Siegel, Renate |d 700000 |d 711000 |d 50000 |e 700000PK1050022335 |e 711000PK1050022335 |e 50000PK1050022335 |k 0/700000/ |k 1/700000/711000/ |k 0/50000/ |p 8 | ||
| 998 | |g 1119825083 |a Lehmann, Wolf-Dieter |m 1119825083:Lehmann, Wolf-Dieter |d 50000 |e 50000PL1119825083 |k 0/50000/ |p 6 | ||
| 998 | |g 1100399550 |a Dirdjaja, Natalie |m 1100399550:Dirdjaja, Natalie |d 700000 |d 711000 |d 50000 |e 700000PD1100399550 |e 711000PD1100399550 |e 50000PD1100399550 |k 0/700000/ |k 1/700000/711000/ |k 0/50000/ |p 4 | ||
| 999 | |a KXP-PPN1744271550 |e 3832966587 | ||
| BIB | |a Y | ||
| SER | |a journal | ||
| JSO | |a {"relHost":[{"title":[{"title":"Biochemical pharmacology","title_sort":"Biochemical pharmacology"}],"recId":"30631777X","language":["eng"],"note":["Gesehen am 21.02.20"],"disp":"Molecular interaction of artemisinin with translationally controlled tumor protein (TCTP) of Plasmodium falciparumBiochemical pharmacology","type":{"media":"Online-Ressource","bibl":"periodical"},"part":{"issue":"1","pages":"38-45","year":"2013","extent":"8","text":"85(2013), 1, Seite 38-45","volume":"85"},"pubHistory":["1.1958 -"],"id":{"issn":["1873-2968"],"eki":["30631777X"],"zdb":["1496199-4"]},"origin":[{"publisherPlace":"Amsterdam [u.a.]","dateIssuedDisp":"1958-","publisher":"Elsevier Science","dateIssuedKey":"1958"}],"physDesc":[{"extent":"Online-Ressource"}]}],"physDesc":[{"extent":"8 S."}],"name":{"displayForm":["Tolga Eichhorn, Dominic Winter, Berthold Büchele, Natalie Dirdjaja, Martin Frank, Wolf-Dieter Lehmann, Rolf Mertens, R. Luise Krauth-Siegel, Thomas Simmet, Joachim Granzin, Thomas Efferth"]},"id":{"doi":["10.1016/j.bcp.2012.10.006"],"eki":["1744271550"]},"origin":[{"dateIssuedDisp":"2013","dateIssuedKey":"2013"}],"language":["eng"],"recId":"1744271550","type":{"media":"Online-Ressource","bibl":"article-journal"},"note":["Available online 17 October 2012","Gesehen am 08.01.2021"],"person":[{"role":"aut","display":"Eichhorn, Tolga","roleDisplay":"VerfasserIn","given":"Tolga","family":"Eichhorn"},{"role":"aut","roleDisplay":"VerfasserIn","display":"Winter, Dominic","given":"Dominic","family":"Winter"},{"family":"Büchele","given":"Berthold","roleDisplay":"VerfasserIn","display":"Büchele, Berthold","role":"aut"},{"roleDisplay":"VerfasserIn","display":"Dirdjaja, Natalie","role":"aut","family":"Dirdjaja","given":"Natalie"},{"given":"Martin","family":"Frank","role":"aut","display":"Frank, Martin","roleDisplay":"VerfasserIn"},{"role":"aut","roleDisplay":"VerfasserIn","display":"Lehmann, Wolf-Dieter","given":"Wolf-Dieter","family":"Lehmann"},{"family":"Mertens","given":"Rolf","roleDisplay":"VerfasserIn","display":"Mertens, Rolf","role":"aut"},{"role":"aut","roleDisplay":"VerfasserIn","display":"Krauth-Siegel, Renate","given":"Renate","family":"Krauth-Siegel"},{"family":"Simmet","given":"Thomas","roleDisplay":"VerfasserIn","display":"Simmet, Thomas","role":"aut"},{"display":"Granzin, Joachim","roleDisplay":"VerfasserIn","role":"aut","family":"Granzin","given":"Joachim"},{"role":"aut","display":"Efferth, Thomas","roleDisplay":"VerfasserIn","given":"Thomas","family":"Efferth"}],"title":[{"title":"Molecular interaction of artemisinin with translationally controlled tumor protein (TCTP) of Plasmodium falciparum","title_sort":"Molecular interaction of artemisinin with translationally controlled tumor protein (TCTP) of Plasmodium falciparum"}]} | ||
| SRT | |a EICHHORNTOMOLECULARI2013 | ||