Impact of ACE I/D gene polymorphism on congenital renal malformations
To investigate the role of the angiotensin converting enzyme (ACE) gene insertion/deletion (I/D) polymorphism on prevalence and progression of disease in children with chronic renal failure (CRF), we determined the ACE I/D genotype in 95 children with CRF due to renal malformations (hypo- /dysplasia...
Gespeichert in:
| Hauptverfasser: | , , , , , |
|---|---|
| Dokumenttyp: | Article (Journal) |
| Sprache: | Englisch |
| Veröffentlicht: |
2001
|
| In: |
Pediatric nephrology
Year: 2001, Jahrgang: 16, Heft: 4, Pages: 356-361 |
| ISSN: | 1432-198X |
| DOI: | 10.1007/s004670100567 |
| Online-Zugang: | Verlag, lizenzpflichtig, Volltext: https://doi.org/10.1007/s004670100567
|
| Verfasserangaben: | K. Hohenfellner, Anne-Margret Wingen, Oliver Nauroth, Elke Wühl, Otto Mehls, Franz Schaefer |
MARC
| LEADER | 00000caa a2200000 c 4500 | ||
|---|---|---|---|
| 001 | 1744300380 | ||
| 003 | DE-627 | ||
| 005 | 20230428055616.0 | ||
| 007 | cr uuu---uuuuu | ||
| 008 | 210111s2001 xx |||||o 00| ||eng c | ||
| 024 | 7 | |a 10.1007/s004670100567 |2 doi | |
| 035 | |a (DE-627)1744300380 | ||
| 035 | |a (DE-599)KXP1744300380 | ||
| 035 | |a (OCoLC)1341385016 | ||
| 040 | |a DE-627 |b ger |c DE-627 |e rda | ||
| 041 | |a eng | ||
| 084 | |a 33 |2 sdnb | ||
| 100 | 1 | |a Hohenfellner, Katharina |e VerfasserIn |0 (DE-588)1224826167 |0 (DE-627)1744299560 |4 aut | |
| 245 | 1 | 0 | |a Impact of ACE I/D gene polymorphism on congenital renal malformations |c K. Hohenfellner, Anne-Margret Wingen, Oliver Nauroth, Elke Wühl, Otto Mehls, Franz Schaefer |
| 264 | 1 | |c 2001 | |
| 300 | |a 6 | ||
| 336 | |a Text |b txt |2 rdacontent | ||
| 337 | |a Computermedien |b c |2 rdamedia | ||
| 338 | |a Online-Ressource |b cr |2 rdacarrier | ||
| 500 | |a Gesehen am 11.01.2021 | ||
| 520 | |a To investigate the role of the angiotensin converting enzyme (ACE) gene insertion/deletion (I/D) polymorphism on prevalence and progression of disease in children with chronic renal failure (CRF), we determined the ACE I/D genotype in 95 children with CRF due to renal malformations (hypo- /dysplasia, obstructive uropathy, reflux nephropathy; n=59), other congenital or hereditary diseases (n=23), or acquired glomerular disorders (n=13), who had been followed prospectively over a 2-year period. CRF progression rate was followed in each individual by linear regression analysis of estimates of glomerular filtration rate (GFR) obtained every 2 months. Actuarial renal ’survival’ analysis was performed, using a GFR loss of 10 ml/min per 1.73 m2 as a cutoff point. The distribution of the ACE genotype did not differ among the disease groups. There was also no difference in ACE genotype distribution between the patients and a control group of healthy Caucasian children (n=163). Among the children with renal malformations, the 2-year renal survival was significantly lower in those with the DD genotype (61%) than in patients with ID or II genotype (89%, P<0.01). In the other disease groups, the ACE I/D genotype was not predictive of CRF progression. In a multivariate analysis of risk factors, the adverse effect of the DD genotype (risk ratio 10.2, P<0.05) was independent of and additive to those of arterial hypertension (RR 13.2, P<0.001) and gross proteinuria (RR 4.7, P<0.05). We conclude that the ACE DD genotype is a significant risk factor for children with congenital renal malformations to develop progressive CRF. The effect of the ACE polymorphism in this patient group is independent of hypertension and proteinuria. | ||
| 700 | 1 | |a Wingen, Anne-Margret |e VerfasserIn |4 aut | |
| 700 | 1 | |a Nauroth, Oliver |e VerfasserIn |4 aut | |
| 700 | 1 | |a Wühl, Elke |e VerfasserIn |0 (DE-588)1069939617 |0 (DE-627)823052052 |0 (DE-576)429626134 |4 aut | |
| 700 | 1 | |a Mehls, Otto |e VerfasserIn |0 (DE-588)1111580413 |0 (DE-627)865658137 |0 (DE-576)476191424 |4 aut | |
| 700 | 1 | |a Schaefer, Franz |d 1961- |e VerfasserIn |0 (DE-588)1023365383 |0 (DE-627)718365577 |0 (DE-576)366705598 |4 aut | |
| 773 | 0 | 8 | |i Enthalten in |t Pediatric nephrology |d Berlin : Springer, 1987 |g 16(2001), 4, Seite 356-361 |h Online-Ressource |w (DE-627)254638872 |w (DE-600)1463004-7 |w (DE-576)074531689 |x 1432-198X |7 nnas |a Impact of ACE I/D gene polymorphism on congenital renal malformations |
| 773 | 1 | 8 | |g volume:16 |g year:2001 |g number:4 |g pages:356-361 |g extent:6 |a Impact of ACE I/D gene polymorphism on congenital renal malformations |
| 856 | 4 | 0 | |u https://doi.org/10.1007/s004670100567 |x Verlag |x Resolving-System |z lizenzpflichtig |3 Volltext |
| 951 | |a AR | ||
| 992 | |a 20210111 | ||
| 993 | |a Article | ||
| 994 | |a 2001 | ||
| 998 | |g 1023365383 |a Schaefer, Franz |m 1023365383:Schaefer, Franz |d 910000 |d 910500 |e 910000PS1023365383 |e 910500PS1023365383 |k 0/910000/ |k 1/910000/910500/ |p 6 |y j | ||
| 998 | |g 1111580413 |a Mehls, Otto |m 1111580413:Mehls, Otto |d 910000 |d 910500 |e 910000PM1111580413 |e 910500PM1111580413 |k 0/910000/ |k 1/910000/910500/ |p 5 | ||
| 998 | |g 1069939617 |a Wühl, Elke |m 1069939617:Wühl, Elke |d 910000 |d 910500 |e 910000PW1069939617 |e 910500PW1069939617 |k 0/910000/ |k 1/910000/910500/ |p 4 | ||
| 999 | |a KXP-PPN1744300380 |e 3834196150 | ||
| BIB | |a Y | ||
| SER | |a journal | ||
| JSO | |a {"language":["eng"],"recId":"1744300380","type":{"media":"Online-Ressource","bibl":"article-journal"},"relHost":[{"physDesc":[{"extent":"Online-Ressource"}],"type":{"media":"Online-Ressource","bibl":"periodical"},"recId":"254638872","language":["eng"],"title":[{"subtitle":"journal of the International Pediatric Nephrology Association","title_sort":"Pediatric nephrology","title":"Pediatric nephrology"}],"note":["Gesehen am 06.12.05"],"disp":"Impact of ACE I/D gene polymorphism on congenital renal malformationsPediatric nephrology","id":{"issn":["1432-198X"],"eki":["254638872"],"zdb":["1463004-7"]},"part":{"extent":"6","volume":"16","pages":"356-361","issue":"4","year":"2001","text":"16(2001), 4, Seite 356-361"},"origin":[{"dateIssuedKey":"1987","publisherPlace":"Berlin ; Heidelberg ; Berlin ; Heidelberg ; New York, NY","publisher":"Springer ; Springer","dateIssuedDisp":"1987-"}],"pubHistory":["1.1987 -"]}],"physDesc":[{"extent":"6 S."}],"name":{"displayForm":["K. Hohenfellner, Anne-Margret Wingen, Oliver Nauroth, Elke Wühl, Otto Mehls, Franz Schaefer"]},"origin":[{"dateIssuedDisp":"2001","dateIssuedKey":"2001"}],"id":{"doi":["10.1007/s004670100567"],"eki":["1744300380"]},"note":["Gesehen am 11.01.2021"],"person":[{"family":"Hohenfellner","role":"aut","given":"Katharina","display":"Hohenfellner, Katharina"},{"display":"Wingen, Anne-Margret","given":"Anne-Margret","role":"aut","family":"Wingen"},{"family":"Nauroth","role":"aut","given":"Oliver","display":"Nauroth, Oliver"},{"display":"Wühl, Elke","role":"aut","given":"Elke","family":"Wühl"},{"display":"Mehls, Otto","given":"Otto","role":"aut","family":"Mehls"},{"role":"aut","given":"Franz","family":"Schaefer","display":"Schaefer, Franz"}],"title":[{"title":"Impact of ACE I/D gene polymorphism on congenital renal malformations","title_sort":"Impact of ACE I/D gene polymorphism on congenital renal malformations"}]} | ||
| SRT | |a HOHENFELLNIMPACTOFAC2001 | ||