Local blood coagulation drives cancer cell arrest and brain metastasis in a mouse model

Clinically relevant brain metastases (BM) frequently form in cancer patients, with limited options for effective treatment. Circulating cancer cells must first permanently arrest in brain microvessels to colonize the brain, but the critical factors are not well understood. Here, in vivo multiphoton...

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Main Authors:	Feinauer, Manuel (Author) , Schneider, Stefan W. (Author) , Bergmeister-Berghoff, Anna Sophie (Author) , Robador Arteta, José Ramon (Author) , Tehranian, Cedric (Author) , Karreman, Matthia A. (Author) , Venkataramani, Varun (Author) , Solecki, Gergely (Author) , Grosch, Julia Katharina (Author) , Gunkel, Katharina (Author) , Kovalchuk, Bogdana (Author) , Mayer, Frank Thomas (Author) , Fischer, Manuel (Author) , Breckwoldt, Michael O. (Author) , Brune, Maik (Author) , Schwab, Yannik (Author) , Wick, Wolfgang (Author) , Bauer, Alexander (Author) , Winkler, Frank (Author)
Format:	Article (Journal)
Language:	English
Published:	December 3, 2020
In:	Blood Year: 2021, Volume: 137, Issue: 9, Pages: 1219-1232
ISSN:	1528-0020
DOI:	10.1182/blood.2020005710
Online Access:	Resolving-System, lizenzpflichtig, Volltext: https://doi.org/10.1182/blood.2020005710 Verlag, lizenzpflichtig, Volltext: https://ashpublications.org/blood/article/doi/10.1182/blood.2020005710/474386/Local-blood-coagulation-drives-cancer-cell-arrest
Author Notes:	Manuel J. Feinauer, Stefan W. Schneider, Anna Sophie Berghoff, Jose Ramon Robador, Cedric Tehranian, Matthia A. Karreman, Varun Venkataramani, Gergely Solecki, Julia Katharina Grosch, Katharina Gunkel, Bogdana Kovalchuk, Frank Thomas Mayer, Manuel Fischer, Michael O. Breckwoldt, Maik Brune, Yannik Schwab, Wolfgang Wick, Alexander Thomas Bauer and Frank Winkler