Local blood coagulation drives cancer cell arrest and brain metastasis in a mouse model
Clinically relevant brain metastases (BM) frequently form in cancer patients, with limited options for effective treatment. Circulating cancer cells must first permanently arrest in brain microvessels to colonize the brain, but the critical factors are not well understood. Here, in vivo multiphoton...
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| Main Authors: | , , , , , , , , , , , , , , , , , , |
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| Format: | Article (Journal) |
| Language: | English |
| Published: |
December 3, 2020
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| In: |
Blood
Year: 2021, Volume: 137, Issue: 9, Pages: 1219-1232 |
| ISSN: | 1528-0020 |
| DOI: | 10.1182/blood.2020005710 |
| Online Access: | Resolving-System, lizenzpflichtig, Volltext: https://doi.org/10.1182/blood.2020005710 Verlag, lizenzpflichtig, Volltext: https://ashpublications.org/blood/article/doi/10.1182/blood.2020005710/474386/Local-blood-coagulation-drives-cancer-cell-arrest 
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| Author Notes: | Manuel J. Feinauer, Stefan W. Schneider, Anna Sophie Berghoff, Jose Ramon Robador, Cedric Tehranian, Matthia A. Karreman, Varun Venkataramani, Gergely Solecki, Julia Katharina Grosch, Katharina Gunkel, Bogdana Kovalchuk, Frank Thomas Mayer, Manuel Fischer, Michael O. Breckwoldt, Maik Brune, Yannik Schwab, Wolfgang Wick, Alexander Thomas Bauer and Frank Winkler |
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| 520 | |a Clinically relevant brain metastases (BM) frequently form in cancer patients, with limited options for effective treatment. Circulating cancer cells must first permanently arrest in brain microvessels to colonize the brain, but the critical factors are not well understood. Here, in vivo multiphoton laser-scanning microscopy (MPLSM) of the entire brain metastatic cascade allowed unprecedented insights into how blood clot formation and von Willebrand factor (VWF) deposition determine the arrest of circulating cancer cells and subsequent brain colonization in mice. | ||
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