Exocyclic DNA adducts as oxidative stress markers in colon carcinogenesis: potential role of lipid peroxidation, dietary fat and antioxidants
<section class="abstract"><h2 class="abstractTitle text-title my-1" id="d2156e2">Abstract</h2><p>Molecular pathways to colorectal cancer involve multiple - genetic changes, whereby extensive oxyradical - damage causes mutations in cancerrelated g...
Saved in:
| Main Authors: | , , |
|---|---|
| Format: | Article (Journal) |
| Language: | English |
| Published: |
01.06.2005
|
| In: |
Biological chemistry
Year: 2002, Volume: 383, Issue: 6, Pages: 915-921 |
| ISSN: | 1437-4315 |
| DOI: | 10.1515/BC.2002.098 |
| Online Access: | Verlag, lizenzpflichtig, Volltext: https://doi.org/10.1515/BC.2002.098 Verlag, lizenzpflichtig, Volltext: https://www.degruyterbrill.com/view/journals/bchm/383/6/article-p915.xml 
|
| Author Notes: | Helmut Bartsch, Jagadeesan Nair and Robert W. Owen |
MARC
| LEADER | 00000caa a2200000 c 4500 | ||
|---|---|---|---|
| 001 | 1744399638 | ||
| 003 | DE-627 | ||
| 005 | 20250530010324.0 | ||
| 007 | cr uuu---uuuuu | ||
| 008 | 210112r20052002xx |||||o 00| ||eng c | ||
| 024 | 7 | |a 10.1515/BC.2002.098 |2 doi | |
| 035 | |a (DE-627)1744399638 | ||
| 035 | |a (DE-599)KXP1744399638 | ||
| 035 | |a (OCoLC)1341384837 | ||
| 040 | |a DE-627 |b ger |c DE-627 |e rda | ||
| 041 | |a eng | ||
| 084 | |a 33 |2 sdnb | ||
| 100 | 1 | |a Bartsch, Helmut |d 1940- |e VerfasserIn |0 (DE-588)1021102032 |0 (DE-627)691457018 |0 (DE-576)362545545 |4 aut | |
| 245 | 1 | 0 | |a Exocyclic DNA adducts as oxidative stress markers in colon carcinogenesis |b potential role of lipid peroxidation, dietary fat and antioxidants |c Helmut Bartsch, Jagadeesan Nair and Robert W. Owen |
| 264 | 1 | |c 01.06.2005 | |
| 300 | |a 7 | ||
| 336 | |a Text |b txt |2 rdacontent | ||
| 337 | |a Computermedien |b c |2 rdamedia | ||
| 338 | |a Online-Ressource |b cr |2 rdacarrier | ||
| 500 | |a Gesehen am 12.01.2021 | ||
| 500 | |a Elektronische Reproduktion der Druck-Ausgabe | ||
| 520 | |a <section class="abstract"><h2 class="abstractTitle text-title my-1" id="d2156e2">Abstract</h2><p>Molecular pathways to colorectal cancer involve multiple - genetic changes, whereby extensive oxyradical - damage causes mutations in cancerrelated genes - and leads to a cycle of cell death and regeneration. Besides - direct oxidative DNAdamage, reactive oxygen - and nitrogen species can induce etheno ()DNA - adducts mainly via trans-4-hydroxy-2-nonenal, generated - as the major aldehyde by lipid peroxidation (LPO) - of ω-6 PUFAs. Patients with familial adenomatous - polyposis (FAP) develop multiple colorectal adenomas. - In affected tissues increased LPO could be triggered - due to increased arachidonic acid metabolism - as a result of elevated cyclooxygenases. Our studies - demonstrated an increased DNA adduct level in affected - colon epithelia of FAP patients. DNA adducts - are promutagenic and can cause genomic instability - that drives colorectal adenoma to malignancy. We - have further investigated the potential chemopreventive - properties of olive oil and its polyphenolic components. - Mediterranean diet, of which olive oil is a major - fatty acid source, has protective effects against human - breast and colorectal cancers. Olive oil extracts - and the newly identified lignan fractions showed high - antioxidant capacity in vitro. As DNA adducts are - biomarkers for oxidative stress and LPO induced DNA - damage, they can verify the efficacy of newly identified - antioxidants, e.g. from olive oil, as chemopreventive - agents against colon carcinogenesis.</p></section> | ||
| 534 | |c 2002 | ||
| 700 | 1 | |a Nair, Jagadeesan |d 1953-2007 |e VerfasserIn |0 (DE-588)1221688286 |0 (DE-627)1739048865 |4 aut | |
| 700 | 1 | |a Owen, Robert |e VerfasserIn |0 (DE-588)1082251887 |0 (DE-627)847252019 |0 (DE-576)455284539 |4 aut | |
| 773 | 0 | 8 | |i Enthalten in |t Biological chemistry |d Berlin [u.a.] : de Gruyter, 1996 |g 383(2002), 6, Seite 915-921 |h Online-Ressource |w (DE-627)26578168X |w (DE-600)1466062-3 |w (DE-576)074890476 |x 1437-4315 |7 nnas |a Exocyclic DNA adducts as oxidative stress markers in colon carcinogenesis potential role of lipid peroxidation, dietary fat and antioxidants |
| 773 | 1 | 8 | |g volume:383 |g year:2002 |g number:6 |g pages:915-921 |g extent:7 |a Exocyclic DNA adducts as oxidative stress markers in colon carcinogenesis potential role of lipid peroxidation, dietary fat and antioxidants |
| 856 | 4 | 0 | |u https://doi.org/10.1515/BC.2002.098 |x Verlag |x Resolving-System |z lizenzpflichtig |3 Volltext |
| 856 | 4 | 0 | |u https://www.degruyterbrill.com/view/journals/bchm/383/6/article-p915.xml |x Verlag |z lizenzpflichtig |3 Volltext |
| 951 | |a AR | ||
| 992 | |a 20210112 | ||
| 993 | |a Article | ||
| 994 | |a 2002 | ||
| 998 | |g 1082251887 |a Owen, Robert |m 1082251887:Owen, Robert |d 50000 |e 50000PO1082251887 |k 0/50000/ |p 3 |y j | ||
| 998 | |g 1221688286 |a Nair, Jagadeesan |m 1221688286:Nair, Jagadeesan |d 50000 |e 50000PN1221688286 |k 0/50000/ |p 2 | ||
| 998 | |g 1021102032 |a Bartsch, Helmut |m 1021102032:Bartsch, Helmut |d 50000 |e 50000PB1021102032 |k 0/50000/ |p 1 |x j | ||
| 999 | |a KXP-PPN1744399638 |e 3834487767 | ||
| BIB | |a Y | ||
| SER | |a journal | ||
| JSO | |a {"language":["eng"],"recId":"1744399638","note":["Gesehen am 12.01.2021","Elektronische Reproduktion der Druck-Ausgabe"],"type":{"bibl":"article-journal","media":"Online-Ressource"},"title":[{"title":"Exocyclic DNA adducts as oxidative stress markers in colon carcinogenesis","subtitle":"potential role of lipid peroxidation, dietary fat and antioxidants","title_sort":"Exocyclic DNA adducts as oxidative stress markers in colon carcinogenesis"}],"person":[{"role":"aut","roleDisplay":"VerfasserIn","display":"Bartsch, Helmut","given":"Helmut","family":"Bartsch"},{"display":"Nair, Jagadeesan","roleDisplay":"VerfasserIn","role":"aut","family":"Nair","given":"Jagadeesan"},{"roleDisplay":"VerfasserIn","display":"Owen, Robert","role":"aut","family":"Owen","given":"Robert"}],"relHost":[{"physDesc":[{"extent":"Online-Ressource"}],"origin":[{"publisher":"de Gruyter","dateIssuedKey":"1996","dateIssuedDisp":"1996-","publisherPlace":"Berlin [u.a.]"}],"id":{"issn":["1437-4315"],"zdb":["1466062-3"],"doi":["10.1515/bc"],"eki":["26578168X"]},"note":["Gesehen am 24.09.25"],"type":{"bibl":"periodical","media":"Online-Ressource"},"disp":"Exocyclic DNA adducts as oxidative stress markers in colon carcinogenesis potential role of lipid peroxidation, dietary fat and antioxidantsBiological chemistry","language":["eng"],"recId":"26578168X","pubHistory":["377.1996,7/8 -"],"part":{"text":"383(2002), 6, Seite 915-921","volume":"383","extent":"7","year":"2002","pages":"915-921","issue":"6"},"title":[{"title_sort":"Biological chemistry","title":"Biological chemistry"}]}],"physDesc":[{"extent":"7 S."}],"id":{"doi":["10.1515/BC.2002.098"],"eki":["1744399638"]},"origin":[{"dateIssuedDisp":"01.06.2005","dateIssuedKey":"2005"}],"name":{"displayForm":["Helmut Bartsch, Jagadeesan Nair and Robert W. Owen"]}} | ||
| SRT | |a BARTSCHHELEXOCYCLICD0106 | ||