Early inhibition of IL-1β expression by IFN-γ is mediated by impaired binding of NF-[kappa]B to the IL-1β promoter but is independent of nitric oxide
The significance of bacterial RNA recognition for initiating innate immune responses against invading pathogens has only recently started to be elucidated. Bacterial RNA is an important trigger of inflammasome activation, resulting in caspase-1-dependent cleavage of pro-IL-1β into the active form. I...
Saved in:
| Main Authors: | , , |
|---|---|
| Format: | Article (Journal) |
| Language: | English |
| Published: |
10 May 2013
|
| In: |
The journal of immunology
Year: 2013, Volume: 190, Issue: 12, Pages: 6533-6541 |
| ISSN: | 1550-6606 |
| DOI: | 10.4049/jimmunol.1300324 |
| Online Access: | Verlag, lizenzpflichtig, Volltext: https://doi.org/10.4049/jimmunol.1300324 Verlag, lizenzpflichtig, Volltext: https://www.jimmunol.org/content/190/12/6533 
|
| Author Notes: | Tatjana Eigenbrod, Konrad A. Bode, and Alexander H. Dalpke |
MARC
| LEADER | 00000caa a2200000 c 4500 | ||
|---|---|---|---|
| 001 | 1744407614 | ||
| 003 | DE-627 | ||
| 005 | 20220819072141.0 | ||
| 007 | cr uuu---uuuuu | ||
| 008 | 210112s2013 xx |||||o 00| ||eng c | ||
| 024 | 7 | |a 10.4049/jimmunol.1300324 |2 doi | |
| 035 | |a (DE-627)1744407614 | ||
| 035 | |a (DE-599)KXP1744407614 | ||
| 035 | |a (OCoLC)1341385125 | ||
| 040 | |a DE-627 |b ger |c DE-627 |e rda | ||
| 041 | |a eng | ||
| 084 | |a 33 |2 sdnb | ||
| 100 | 1 | |a Eigenbrod, Tatjana |d 1978- |e VerfasserIn |0 (DE-588)130317853 |0 (DE-627)497977435 |0 (DE-576)298124068 |4 aut | |
| 245 | 1 | 0 | |a Early inhibition of IL-1β expression by IFN-γ is mediated by impaired binding of NF-[kappa]B to the IL-1β promoter but is independent of nitric oxide |c Tatjana Eigenbrod, Konrad A. Bode, and Alexander H. Dalpke |
| 246 | 3 | 0 | |a κ |
| 246 | 3 | 3 | |a Early inhibition of IL-1 beta expression by IFN- gamma is mediated by impaired binding of NF- kappa B to the IL-1 beta promoter but is independent of nitric oxide |
| 264 | 1 | |c 10 May 2013 | |
| 300 | |a 9 | ||
| 336 | |a Text |b txt |2 rdacontent | ||
| 337 | |a Computermedien |b c |2 rdamedia | ||
| 338 | |a Online-Ressource |b cr |2 rdacarrier | ||
| 500 | |a Im Titel ist "kappa" als griechischer Buchstabe dargestellt | ||
| 500 | |a Gesehen am 12.01.2021 | ||
| 520 | |a The significance of bacterial RNA recognition for initiating innate immune responses against invading pathogens has only recently started to be elucidated. Bacterial RNA is an important trigger of inflammasome activation, resulting in caspase-1-dependent cleavage of pro-IL-1β into the active form. It was reported previously that prolonged treatment with IFN-γ can inhibit IL-1β production at the level of both transcription and Nlrp3 inflammasome activation in an NO-dependent manner. As a result of the delayed kinetics of NO generation after IFN-γ stimulation, these effects were only observed at later time points. We report that IFN-γ suppressed bacterial RNA and LPS induced IL-1β transcription in primary murine macrophages and dendritic cells by an additional, very rapid mechanism that was independent of NO. Costimulation with IFN-γ selectively attenuated binding of NF-κB p65 to the IL-1β promoter, thus representing a novel mechanism of IL-1β inhibition by IFN-γ. Transcriptional silencing was specific for IL-1β because expression of other proinflammatory cytokines, such as TNF, IL-6, and IL-12p40, was not affected. Furthermore, by suppressing IL-1β production, IFN-γ impaired differentiation of Th17 cells and production of neutrophil chemotactic factor CXCL1 in vitro. The findings provide evidence for a rapid immune-modulating effect of IFN-γ independent of NO. | ||
| 700 | 1 | |a Bode, Konrad A. |d 1969- |e VerfasserIn |0 (DE-588)128891270 |0 (DE-627)384629334 |0 (DE-576)297385836 |4 aut | |
| 700 | 1 | |a Dalpke, Alexander |d 1971- |e VerfasserIn |0 (DE-588)123821878 |0 (DE-627)706438523 |0 (DE-576)293894272 |4 aut | |
| 773 | 0 | 8 | |i Enthalten in |t The journal of immunology |d Rockville, Md. : American Association of Immunologists, 1916 |g 190(2013), 12, Seite 6533-6541 |h Online-Ressource |w (DE-627)269535217 |w (DE-600)1475085-5 |w (DE-576)079963838 |x 1550-6606 |7 nnas |a Early inhibition of IL-1β expression by IFN-γ is mediated by impaired binding of NF-[kappa]B to the IL-1β promoter but is independent of nitric oxide |
| 773 | 1 | 8 | |g volume:190 |g year:2013 |g number:12 |g pages:6533-6541 |g extent:9 |a Early inhibition of IL-1β expression by IFN-γ is mediated by impaired binding of NF-[kappa]B to the IL-1β promoter but is independent of nitric oxide |
| 856 | 4 | 0 | |u https://doi.org/10.4049/jimmunol.1300324 |x Verlag |x Resolving-System |z lizenzpflichtig |3 Volltext |
| 856 | 4 | 0 | |u https://www.jimmunol.org/content/190/12/6533 |x Verlag |z lizenzpflichtig |3 Volltext |
| 951 | |a AR | ||
| 992 | |a 20210112 | ||
| 993 | |a Article | ||
| 994 | |a 2013 | ||
| 998 | |g 123821878 |a Dalpke, Alexander |m 123821878:Dalpke, Alexander |d 910000 |d 911700 |e 910000PD123821878 |e 911700PD123821878 |k 0/910000/ |k 1/910000/911700/ |p 3 |y j | ||
| 998 | |g 128891270 |a Bode, Konrad A. |m 128891270:Bode, Konrad A. |d 50000 |e 50000PB128891270 |k 0/50000/ |p 2 | ||
| 998 | |g 130317853 |a Eigenbrod, Tatjana |m 130317853:Eigenbrod, Tatjana |d 910000 |d 911700 |d 50000 |e 910000PE130317853 |e 911700PE130317853 |e 50000PE130317853 |k 0/910000/ |k 1/910000/911700/ |k 0/50000/ |p 1 |x j | ||
| 999 | |a KXP-PPN1744407614 |e 3834513717 | ||
| BIB | |a Y | ||
| SER | |a journal | ||
| JSO | |a {"name":{"displayForm":["Tatjana Eigenbrod, Konrad A. Bode, and Alexander H. Dalpke"]},"origin":[{"dateIssuedDisp":"10 May 2013","dateIssuedKey":"2013"}],"id":{"doi":["10.4049/jimmunol.1300324"],"eki":["1744407614"]},"physDesc":[{"extent":"9 S."}],"relHost":[{"part":{"issue":"12","pages":"6533-6541","year":"2013","extent":"9","text":"190(2013), 12, Seite 6533-6541","volume":"190"},"pubHistory":["1.1916 -"],"language":["eng"],"corporate":[{"display":"American Association of Immunologists","roleDisplay":"Herausgebendes Organ","role":"isb"}],"recId":"269535217","disp":"Early inhibition of IL-1β expression by IFN-γ is mediated by impaired binding of NF-[kappa]B to the IL-1β promoter but is independent of nitric oxideThe journal of immunology","note":["Gesehen am 18.08.2025"],"type":{"bibl":"periodical","media":"Online-Ressource"},"title":[{"title":"The journal of immunology","title_sort":"journal of immunology"}],"physDesc":[{"extent":"Online-Ressource"}],"id":{"issn":["1550-6606"],"zdb":["1475085-5"],"eki":["269535217"]},"origin":[{"dateIssuedDisp":"2025-","publisher":"Oxford University Press ; Soc. ; American Association of Immunologists","dateIssuedKey":"2025","publisherPlace":"Oxford ; Bethesda, Md. ; Rockville, Md."}],"name":{"displayForm":["American Association of Immunologists"]}}],"person":[{"roleDisplay":"VerfasserIn","display":"Eigenbrod, Tatjana","role":"aut","family":"Eigenbrod","given":"Tatjana"},{"role":"aut","display":"Bode, Konrad A.","roleDisplay":"VerfasserIn","given":"Konrad A.","family":"Bode"},{"roleDisplay":"VerfasserIn","display":"Dalpke, Alexander","role":"aut","family":"Dalpke","given":"Alexander"}],"title":[{"title":"Early inhibition of IL-1β expression by IFN-γ is mediated by impaired binding of NF-[kappa]B to the IL-1β promoter but is independent of nitric oxide","title_sort":"Early inhibition of IL-1β expression by IFN-γ is mediated by impaired binding of NF-[kappa]B to the IL-1β promoter but is independent of nitric oxide"}],"type":{"media":"Online-Ressource","bibl":"article-journal"},"note":["Im Titel ist \"kappa\" als griechischer Buchstabe dargestellt","Gesehen am 12.01.2021"],"language":["eng"],"recId":"1744407614","titleAlt":[{"title":"Early inhibition of IL-1 beta expression by IFN- gamma is mediated by impaired binding of NF- kappa B to the IL-1 beta promoter but is independent of nitric oxide"}]} | ||
| SRT | |a EIGENBRODTEARLYINHIB1020 | ||