TLR7 inhibition: a novel strategy for pancreatic cancer treatment?
Pancreatic ductal adenocarcinoma is associated with a poor prognosis: For local disease, the 5-y survival rate is approximately 20% and median survival in locally advanced disease is only about 10 mo. Carcinogenesis is associated with chronic inflammation showing that innate immunity can be a double...
Gespeichert in:
| Hauptverfasser: | , |
|---|---|
| Dokumenttyp: | Article (Journal) |
| Sprache: | Englisch |
| Veröffentlicht: |
01 January 2013
|
| In: |
JAK-STAT
Year: 2013, Jahrgang: 2, Heft: 1 |
| ISSN: | 2162-3996 |
| DOI: | 10.4161/jkst.23011 |
| Online-Zugang: | Verlag, lizenzpflichtig, Volltext: https://doi.org/10.4161/jkst.23011
|
| Verfasserangaben: | Tatjana Eigenbrod and Alexander H. Dalpke |
MARC
| LEADER | 00000caa a2200000 c 4500 | ||
|---|---|---|---|
| 001 | 1744412626 | ||
| 003 | DE-627 | ||
| 005 | 20230428033018.0 | ||
| 007 | cr uuu---uuuuu | ||
| 008 | 210112s2013 xx |||||o 00| ||eng c | ||
| 024 | 7 | |a 10.4161/jkst.23011 |2 doi | |
| 035 | |a (DE-627)1744412626 | ||
| 035 | |a (DE-599)KXP1744412626 | ||
| 035 | |a (OCoLC)1341385047 | ||
| 040 | |a DE-627 |b ger |c DE-627 |e rda | ||
| 041 | |a eng | ||
| 084 | |a 33 |2 sdnb | ||
| 100 | 1 | |a Eigenbrod, Tatjana |d 1978- |e VerfasserIn |0 (DE-588)130317853 |0 (DE-627)497977435 |0 (DE-576)298124068 |4 aut | |
| 245 | 1 | 0 | |a TLR7 inhibition |b a novel strategy for pancreatic cancer treatment? |c Tatjana Eigenbrod and Alexander H. Dalpke |
| 264 | 1 | |c 01 January 2013 | |
| 336 | |a Text |b txt |2 rdacontent | ||
| 337 | |a Computermedien |b c |2 rdamedia | ||
| 338 | |a Online-Ressource |b cr |2 rdacarrier | ||
| 500 | |a Gesehen am 12.01.2021 | ||
| 520 | |a Pancreatic ductal adenocarcinoma is associated with a poor prognosis: For local disease, the 5-y survival rate is approximately 20% and median survival in locally advanced disease is only about 10 mo. Carcinogenesis is associated with chronic inflammation showing that innate immunity can be a double-edged sword. Here, we discuss recent findings of Ochi et al. in The Journal of Clinical Investigation who described a novel role for TLR7 in the development and progression of pancreatic cancer through interference with cell cycle regulation and by activation of multiple cell signaling pathways. Of note, inhibition of TLR7 signaling in a mouse p48Cre;KrasG12D pancreatic cancer model protected against tumor progression thus paving the road for TLR-blocking strategies to combat tumors. | ||
| 650 | 4 | |a cancer | |
| 650 | 4 | |a inflammation | |
| 650 | 4 | |a inhibition | |
| 650 | 4 | |a innate immunity | |
| 650 | 4 | |a pancreas | |
| 650 | 4 | |a therapy | |
| 650 | 4 | |a Toll-like receptors | |
| 700 | 1 | |a Dalpke, Alexander |d 1971- |e VerfasserIn |0 (DE-588)123821878 |0 (DE-627)706438523 |0 (DE-576)293894272 |4 aut | |
| 773 | 0 | 8 | |i Enthalten in |t JAK-STAT |d London : Taylor & Francis Group, 2012 |g 2(2013,1) Artikel-Nummer e23011, 4 Seiten |h Online-Ressource |w (DE-627)726126144 |w (DE-600)2682221-0 |w (DE-576)48628302X |x 2162-3996 |7 nnas |a TLR7 inhibition a novel strategy for pancreatic cancer treatment? |
| 773 | 1 | 8 | |g volume:2 |g year:2013 |g number:1 |a TLR7 inhibition a novel strategy for pancreatic cancer treatment? |
| 856 | 4 | 0 | |u https://doi.org/10.4161/jkst.23011 |x Verlag |x Resolving-System |z lizenzpflichtig |3 Volltext |
| 951 | |a AR | ||
| 992 | |a 20210112 | ||
| 993 | |a Article | ||
| 994 | |a 2013 | ||
| 998 | |g 123821878 |a Dalpke, Alexander |m 123821878:Dalpke, Alexander |d 910000 |d 911700 |e 910000PD123821878 |e 911700PD123821878 |k 0/910000/ |k 1/910000/911700/ |p 2 |y j | ||
| 998 | |g 130317853 |a Eigenbrod, Tatjana |m 130317853:Eigenbrod, Tatjana |d 910000 |d 911700 |d 50000 |e 910000PE130317853 |e 911700PE130317853 |e 50000PE130317853 |k 0/910000/ |k 1/910000/911700/ |k 0/50000/ |p 1 |x j | ||
| 999 | |a KXP-PPN1744412626 |e 3834525537 | ||
| BIB | |a Y | ||
| SER | |a journal | ||
| JSO | |a {"recId":"1744412626","id":{"eki":["1744412626"],"doi":["10.4161/jkst.23011"]},"origin":[{"dateIssuedKey":"2013","dateIssuedDisp":"01 January 2013"}],"type":{"bibl":"article-journal","media":"Online-Ressource"},"person":[{"given":"Tatjana","family":"Eigenbrod","display":"Eigenbrod, Tatjana","role":"aut"},{"role":"aut","family":"Dalpke","display":"Dalpke, Alexander","given":"Alexander"}],"relHost":[{"physDesc":[{"extent":"Online-Ressource"}],"language":["eng"],"title":[{"title":"JAK-STAT","title_sort":"JAK-STAT"}],"note":["Gesehen am 15.05.2020"],"origin":[{"publisher":"Taylor & Francis Group ; Landes Bioscience","dateIssuedDisp":"[2012-2016]","publisherPlace":"London ; Austin, Tex."}],"id":{"zdb":["2682221-0"],"eki":["726126144"],"issn":["2162-3996"]},"pubHistory":["Volume 1, issue 1 (2012)-volume 5, issue 2/4 (2016) ; damit Erscheinen eingestellt"],"part":{"volume":"2","year":"2013","issue":"1","text":"2(2013,1) Artikel-Nummer e23011, 4 Seiten"},"disp":"TLR7 inhibition a novel strategy for pancreatic cancer treatment?JAK-STAT","recId":"726126144","type":{"bibl":"periodical","media":"Online-Ressource"}}],"language":["eng"],"title":[{"title":"TLR7 inhibition","subtitle":"a novel strategy for pancreatic cancer treatment?","title_sort":"TLR7 inhibition"}],"name":{"displayForm":["Tatjana Eigenbrod and Alexander H. Dalpke"]},"note":["Gesehen am 12.01.2021"]} | ||
| SRT | |a EIGENBRODTTLR7INHIBI0120 | ||