Influence of dietary fatty acid, vegetable, and vitamin intake on etheno-DNA adducts in white blood cells of healthy female volunteers: a pilot study
<p>Etheno-DNA adducts such as 1,<i>N</i><sup>6</sup>-ethenodeoxyadenosine (εdA) and <i>N</i><sup>2</sup>,3-ethenodeoxycytidine (εdC) are formed as result of oxidative stress and lipid peroxidation via reactive alkenals (J. Nair <i>et al.<...
Gespeichert in:
| Hauptverfasser: | , , , |
|---|---|
| Dokumenttyp: | Article (Journal) |
| Sprache: | Englisch |
| Veröffentlicht: |
November 1, 2001
|
| In: |
Cancer epidemiology, biomarkers & prevention
Year: 2001, Jahrgang: 10, Heft: 11, Pages: 1187-1191 |
| ISSN: | 1538-7755 |
| Online-Zugang: | Verlag, lizenzpflichtig, Volltext: https://cebp.aacrjournals.org/content/10/11/1187
|
| Verfasserangaben: | Tina Hagenlocher, Jagadeesan Nair, Nikolaus Becker, Andrea Korfmann, and Helmut Bartsch |
MARC
| LEADER | 00000caa a2200000 c 4500 | ||
|---|---|---|---|
| 001 | 1744444676 | ||
| 003 | DE-627 | ||
| 005 | 20220819072628.0 | ||
| 007 | cr uuu---uuuuu | ||
| 008 | 210112s2001 xx |||||o 00| ||eng c | ||
| 035 | |a (DE-627)1744444676 | ||
| 035 | |a (DE-599)KXP1744444676 | ||
| 035 | |a (OCoLC)1341385003 | ||
| 040 | |a DE-627 |b ger |c DE-627 |e rda | ||
| 041 | |a eng | ||
| 084 | |a 33 |2 sdnb | ||
| 100 | 1 | |a Keßler, Tina |d 1969- |e VerfasserIn |0 (DE-588)123461049 |0 (DE-627)706306961 |0 (DE-576)293718512 |4 aut | |
| 245 | 1 | 0 | |a Influence of dietary fatty acid, vegetable, and vitamin intake on etheno-DNA adducts in white blood cells of healthy female volunteers |b a pilot study |c Tina Hagenlocher, Jagadeesan Nair, Nikolaus Becker, Andrea Korfmann, and Helmut Bartsch |
| 264 | 1 | |c November 1, 2001 | |
| 300 | |a 5 | ||
| 336 | |a Text |b txt |2 rdacontent | ||
| 337 | |a Computermedien |b c |2 rdamedia | ||
| 338 | |a Online-Ressource |b cr |2 rdacarrier | ||
| 500 | |a Gesehen am 12.01.2001 | ||
| 520 | |a <p>Etheno-DNA adducts such as 1,<i>N</i><sup>6</sup>-ethenodeoxyadenosine (εdA) and <i>N</i><sup>2</sup>,3-ethenodeoxycytidine (εdC) are formed as result of oxidative stress and lipid peroxidation via reactive alkenals (J. Nair <i>et al.</i>, Mutat. Res., <i>424:</i>59-69, 1999). High ϖ-6 polyunsaturated fatty acid intake markedly increased levels of WBCs in female volunteers on a controlled diet (J. Nair <i>et al.</i>, Cancer Epidemiol. Biomark. Prev., <i>6:</i>591-601, 1997). In healthy female volunteers we investigated possible correlations between dietary fatty acid intake (by questionnaire), concentration of linoleic acid (LA) and oleic acid (OA) in serum (<i>n</i> = 34), and etheno-DNA adduct levels in WBC (<i>n</i> = 42). Two groups of samples were selected according to dietary intake >15 g (group A) or <5 g (group B) LA/day. Serum samples were analyzed for free OA and LA by gas chromatography-mass spectroscopy and WBC-DNA for εdA and εdC adducts by immunoaffinity <sup>32</sup>P postlabeling. On a group level, serum LA and OA concentrations were higher in group A than group B, whereas the LA/OA ratios were similar. The mean εdA and εdC levels did not significantly differ in groups A and B, but a third of the individuals had more than twice the mean adduct levels than the rest. Correlation analyses revealed a significant inverse correlation for εdA in WBC-DNA and vegetable or vitamin E consumption. We conclude that etheno-DNA adduct levels are not determined by LA intake alone but might depend on the ratio of ϖ-6 polyunsaturated fatty acid:other fatty acids and of antioxidants consumed in the diet. This pilot study also indicated a protective effect of dietary vitamin E and vegetables against miscoding, lipid peroxidation-induced DNA lesions.</p> | ||
| 700 | 1 | |a Nair, Jagadeesan |d 1953-2007 |e VerfasserIn |0 (DE-588)1221688286 |0 (DE-627)1739048865 |4 aut | |
| 700 | 1 | |a Becker, Nikolaus |d 1950- |e VerfasserIn |0 (DE-588)124780962 |0 (DE-627)706711084 |0 (DE-576)186605765 |4 aut | |
| 700 | 1 | |a Bartsch, Helmut |d 1940- |e VerfasserIn |0 (DE-588)1021102032 |0 (DE-627)691457018 |0 (DE-576)362545545 |4 aut | |
| 773 | 0 | 8 | |i Enthalten in |t Cancer epidemiology, biomarkers & prevention |d Philadelphia, Pa. : AACR, 1991 |g 10(2001), 11, Seite 1187-1191 |h Online-Ressource |w (DE-627)325489912 |w (DE-600)2036781-8 |w (DE-576)094752745 |x 1538-7755 |7 nnas |a Influence of dietary fatty acid, vegetable, and vitamin intake on etheno-DNA adducts in white blood cells of healthy female volunteers a pilot study |
| 773 | 1 | 8 | |g volume:10 |g year:2001 |g number:11 |g pages:1187-1191 |g extent:5 |a Influence of dietary fatty acid, vegetable, and vitamin intake on etheno-DNA adducts in white blood cells of healthy female volunteers a pilot study |
| 856 | 4 | 0 | |u https://cebp.aacrjournals.org/content/10/11/1187 |x Verlag |z lizenzpflichtig |3 Volltext |
| 951 | |a AR | ||
| 992 | |a 20210112 | ||
| 993 | |a Article | ||
| 994 | |a 2001 | ||
| 998 | |g 1021102032 |a Bartsch, Helmut |m 1021102032:Bartsch, Helmut |d 50000 |e 50000PB1021102032 |k 0/50000/ |p 5 |y j | ||
| 998 | |g 124780962 |a Becker, Nikolaus |m 124780962:Becker, Nikolaus |d 50000 |e 50000PB124780962 |k 0/50000/ |p 3 | ||
| 998 | |g 1221688286 |a Nair, Jagadeesan |m 1221688286:Nair, Jagadeesan |d 50000 |e 50000PN1221688286 |k 0/50000/ |p 2 | ||
| 999 | |a KXP-PPN1744444676 |e 3834574953 | ||
| BIB | |a Y | ||
| SER | |a journal | ||
| JSO | |a {"relHost":[{"title":[{"title":"Cancer epidemiology, biomarkers & prevention","title_sort":"Cancer epidemiology, biomarkers & prevention"}],"type":{"bibl":"periodical","media":"Online-Ressource"},"note":["Gesehen am 08.06.2023","Fortsetzung der Druck-Ausgabe"],"disp":"Influence of dietary fatty acid, vegetable, and vitamin intake on etheno-DNA adducts in white blood cells of healthy female volunteers a pilot studyCancer epidemiology, biomarkers & prevention","recId":"325489912","language":["eng"],"pubHistory":["1.1991/92 -"],"part":{"pages":"1187-1191","issue":"11","year":"2001","extent":"5","volume":"10","text":"10(2001), 11, Seite 1187-1191"},"name":{"displayForm":["American Association for Cancer Research"]},"origin":[{"dateIssuedKey":"1991","publisher":"AACR","dateIssuedDisp":"1991-","publisherPlace":"Philadelphia, Pa."}],"id":{"zdb":["2036781-8"],"eki":["325489912"],"issn":["1538-7755"]},"physDesc":[{"extent":"Online-Ressource"}]}],"physDesc":[{"extent":"5 S."}],"id":{"eki":["1744444676"]},"origin":[{"dateIssuedDisp":"November 1, 2001","dateIssuedKey":"2001"}],"name":{"displayForm":["Tina Hagenlocher, Jagadeesan Nair, Nikolaus Becker, Andrea Korfmann, and Helmut Bartsch"]},"recId":"1744444676","language":["eng"],"note":["Gesehen am 12.01.2001"],"type":{"bibl":"article-journal","media":"Online-Ressource"},"title":[{"title_sort":"Influence of dietary fatty acid, vegetable, and vitamin intake on etheno-DNA adducts in white blood cells of healthy female volunteers","subtitle":"a pilot study","title":"Influence of dietary fatty acid, vegetable, and vitamin intake on etheno-DNA adducts in white blood cells of healthy female volunteers"}],"person":[{"family":"Keßler","given":"Tina","display":"Keßler, Tina","roleDisplay":"VerfasserIn","role":"aut"},{"roleDisplay":"VerfasserIn","display":"Nair, Jagadeesan","role":"aut","family":"Nair","given":"Jagadeesan"},{"given":"Nikolaus","family":"Becker","role":"aut","display":"Becker, Nikolaus","roleDisplay":"VerfasserIn"},{"roleDisplay":"VerfasserIn","display":"Bartsch, Helmut","role":"aut","family":"Bartsch","given":"Helmut"}]} | ||
| SRT | |a KESSLERTININFLUENCEO1200 | ||