Impaired JAK-STAT signal transduction contributes to growth hormone resistance in chronic uremia
Chronic renal failure (CRF) is associated with resistance to the growth-promoting and anabolic actions of growth hormone (GH). In rats with CRF induced by partial renal ablation, 7 days of GH treatment had a diminished effect on weight gain and hepatic IGF-1 and IGFBP-1 mRNA levels, compared with sh...
Gespeichert in:
| Hauptverfasser: | , , , , |
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| Dokumenttyp: | Article (Journal) |
| Sprache: | Englisch |
| Veröffentlicht: |
August 1, 2001
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| In: |
The journal of clinical investigation
Year: 2001, Jahrgang: 108, Heft: 3, Pages: 467-475 |
| ISSN: | 1558-8238 |
| DOI: | 10.1172/JCI11895 |
| Online-Zugang: | Resolving-System, lizenzpflichtig, Volltext: https://doi.org/10.1172/JCI11895 Verlag, lizenzpflichtig, Volltext: https://www.jci.org/articles/view/11895 
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| Verfasserangaben: | Franz Schaefer, Yu Chen, Tanny Tsao, Pouneh Nouri, and Ralph Rabkin |
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| 520 | |a Chronic renal failure (CRF) is associated with resistance to the growth-promoting and anabolic actions of growth hormone (GH). In rats with CRF induced by partial renal ablation, 7 days of GH treatment had a diminished effect on weight gain and hepatic IGF-1 and IGFBP-1 mRNA levels, compared with sham-operated pair-fed controls. | ||
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