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Improved acidosis correction and recovery of mesothelial cell mass with neutral-pH bicarbonate dialysis solution among children undergoing automated peritoneal dialysis

Acid-base balance and peritoneal membrane longevity are of utmost relevance for pediatric patients undergoing peritoneal dialysis (PD). PD fluids with neutral pH and reduced glucose degradation product contents are considered more biocompatible, because they preserve peritoneal cell functions in vit...

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Main Authors: Haas, Susanne (Author) , Schmitt, Claus P. (Author) , Arbeiter, Klaus (Author) , Bonzel, Klaus-Eugen (Author) , Fischbach, Michel (Author) , John, Ulrike (Author) , Pieper, Anne-Kathrin (Author) , Schaub, Thomas Patrick (Author) , Passlick-Deetjen, Jutta (Author) , Mehls, Otto (Author) , Schaefer, Franz (Author)
Format: Article (Journal)
Language:English
Published: September 26, 2003
In: Journal of the American Society of Nephrology
Year: 2003, Volume: 14, Issue: 10, Pages: 2632-2638
ISSN:1533-3450
DOI:10.1097/01.ASN.0000086475.83211.DF
Online Access:Resolving-System, lizenzpflichtig, Volltext: https://doi.org/10.1097/01.ASN.0000086475.83211.DF
Verlag, lizenzpflichtig, Volltext: https://jasn.asnjournals.org/content/14/10/2632
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Author Notes:Susanne Haas, Claus Peter Schmitt, Klaus Arbeiter, Klaus-Eugen Bonzel, Michel Fischbach, Ulrike John, Anne-Kathrin Pieper, Thomas Patrick Schaub, Jutta Passlick-Deetjen, Otto Mehls, and Franz Schaefer
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Summary:Acid-base balance and peritoneal membrane longevity are of utmost relevance for pediatric patients undergoing peritoneal dialysis (PD). PD fluids with neutral pH and reduced glucose degradation product contents are considered more biocompatible, because they preserve peritoneal cell functions in vitro. To investigate the clinical effects of a novel PD fluid buffered with 34 mM pure bicarbonate at neutral pH, a randomized, prospective, crossover comparison with conventional, acidic, 35 mM lactate PD fluid was performed for two consecutive 12-wk periods with 28 children (age, 6 mo to 15 yr) undergoing automated PD (APD).
Item Description:Gesehen am 13.01.2021
Physical Description:Online Resource
ISSN:1533-3450
DOI:10.1097/01.ASN.0000086475.83211.DF

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