Buchumschlag

MiR-218 affects hypertrophic differentiation of human mesenchymal stromal cells during chondrogenesis via targeting RUNX2, MEF2C, and COL10A1

Human mesenchymal stromal cells (MSC) hold hopes for cartilage regenerative therapy due to their chondrogenic differentiation potential. However, undesirable occurrence of calcification after ectopic transplantation, known as hypertrophic degeneration, remains the major obstacle limiting application...

Ausführliche Beschreibung

Gespeichert in:
Bibliographische Detailangaben
Hauptverfasser: Melnik, Svitlana (VerfasserIn) , Gabler, Jessica (VerfasserIn) , Dreher, Simon I. (VerfasserIn) , Hecht, Nicole (VerfasserIn) , Hofmann, Nina (VerfasserIn) , Großner, Tobias (VerfasserIn) , Richter, Wiltrud (VerfasserIn)
Dokumenttyp: Article (Journal)
Sprache:Englisch
Veröffentlicht: 10 December 2020
In: Stem cell research & therapy
Year: 2020, Jahrgang: 11, Pages: 1-18
ISSN:1757-6512
DOI:10.1186/s13287-020-02026-6
Online-Zugang:Verlag, kostenfrei, Volltext: https://doi.org/10.1186/s13287-020-02026-6
Volltext
Verfasserangaben:Svitlana Melnik, Jessica Gabler, Simon I. Dreher, Nicole Hecht, Nina Hofmann, Tobias Großner and Wiltrud Richter
Beschreibung
Zusammenfassung:Human mesenchymal stromal cells (MSC) hold hopes for cartilage regenerative therapy due to their chondrogenic differentiation potential. However, undesirable occurrence of calcification after ectopic transplantation, known as hypertrophic degeneration, remains the major obstacle limiting application of MSC in cartilage tissue regeneration approaches. There is growing evidence that microRNAs (miRs) play essential roles in post-transcriptional regulation of hypertrophic differentiation during chondrogenesis. Aim of the study was to identify new miR candidates involved in repression of hypertrophy-related targets.
Beschreibung:Gesehen am 18.01.2021
Beschreibung:Online Resource
ISSN:1757-6512
DOI:10.1186/s13287-020-02026-6

Ähnliche Einträge