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Fundamental properties of unperturbed haematopoiesis from stem cells in vivo

Inducible genetic labelling of haematopoietic stem cells (HSCs) and linked mathematical modelling show that at least 30% of all HSCs are productive, and that adult haematopoiesis is largely sustained by ‘short-term’ downstream stem cells that operate near self-renewal in the steady state; HSC fate m...

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Main Authors: Busch, Katrin (Author) , Klapproth, Kay (Author) , Barile, Melania (Author) , Floßdorf, Michael (Author) , Holland-Letz, Tim (Author) , Schlenner, Susan M. (Author) , Reth, Michael (Author) , Höfer, Thomas (Author) , Rodewald, Hans-Reimer (Author)
Format: Article (Journal)
Language:English
Published: 11 February 2015
In: Nature
Year: 2015, Volume: 518, Issue: 7540, Pages: 542-546
ISSN:1476-4687
DOI:10.1038/nature14242
Online Access:Verlag, lizenzpflichtig, Volltext: https://doi.org/10.1038/nature14242
Verlag, lizenzpflichtig, Volltext: https://www.nature.com/articles/nature14242
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Author Notes:Katrin Busch, Kay Klapproth, Melania Barile, Michael Flossdorf, Tim Holland-Letz, Susan M. Schlenner, Michael Reth, Thomas Höfer, Hans-Reimer Rodewald
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Summary:Inducible genetic labelling of haematopoietic stem cells (HSCs) and linked mathematical modelling show that at least 30% of all HSCs are productive, and that adult haematopoiesis is largely sustained by ‘short-term’ downstream stem cells that operate near self-renewal in the steady state; HSC fate mapping provides a quantitative model for better understanding of HSC functions in health and disease.
Item Description:Gesehen am 18.01.2021
Physical Description:Online Resource
ISSN:1476-4687
DOI:10.1038/nature14242

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