Motor dysfunction and sensorimotor cortex activation changes in schizophrenia: a study with functional magnetc resonance imaging
Recent studies demonstrate a diminished activation of the sensorimotor cortex and supplementary motor area (SMA) in schizophrenia which may be involved in the pathogenesis of neurological soft signs (NSS). Yet, the question whether a retarded motor performance may account for these changes remained...
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| Main Authors: | , , , , , , , |
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| Format: | Article (Journal) |
| Language: | English |
| Published: |
25 May 2002
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| In: |
NeuroImage
Year: 1999, Volume: 9, Issue: 1, Pages: 81-87 |
| ISSN: | 1095-9572 |
| DOI: | 10.1006/nimg.1998.0387 |
| Online Access: | Verlag, lizenzpflichtig, Volltext: https://doi.org/10.1006/nimg.1998.0387 Verlag, lizenzpflichtig, Volltext: http://www.sciencedirect.com/science/article/pii/S1053811998903871 
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| Author Notes: | Johannes Schröder, Marco Essig, Klaus Baudendistel, Thomas Jahn, Ingo Gerdsen, Andreas Stockert, Lothar R. Schad, Michael V. Knopp |
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| 520 | |a Recent studies demonstrate a diminished activation of the sensorimotor cortex and supplementary motor area (SMA) in schizophrenia which may be involved in the pathogenesis of neurological soft signs (NSS). Yet, the question whether a retarded motor performance may account for these changes remained to be clarified. Twelve DSM-III-R schizophrenics and 12 healthy controls were included. All subjects were right-handed. Nine patients received clozapine, two conventional neuroleptics, and one was drug-free. Functional magnetic resonance imaging (fMRI) was obtained in a resting condition and during pronation/supination at three speed levels (low, medium, and high) with motor performance recorded simultaneously using a pronation/supination device. While measures of motor retardation (i.e., repetition rate and amplitude of the movements) did not differ between patients and controls, the variability of performance was significantly (P<0.05) increased in the patients' group. In addition, patients with schizophrenia showed a significantly (P<0.05) decreased activation of the sensorimotor cortices. Similar, although nonsignificant (P=0.09) activation changes were observed in the SMA. Activation differences were more pronounced at a slow speed and in the drug-free patient. These results confirm a diminished sensorimotor cortex and SMA activation and indicate that variability of performance rather than retarded performance per se may correspond to these changes. | ||
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