Frontotemporal dementia: clinical, neuroimaging, and molecular biological findings in 6 patients
Establishing the diagnosis in patients with clinical signs and symptoms suggesting primary degenerative disease with marked frontal lobe involvement is difficult. Neuroimaging methods, in particular positron emission tomography (PET) with the tracer 18fluoro-2-deoxyglucose (FDG) and cerebrospinal fl...
Saved in:
| Main Authors: | , , , , , , , |
|---|---|
| Format: | Article (Journal) |
| Language: | English |
| Published: |
October 2001
|
| In: |
European archives of psychiatry and clinical neuroscience
Year: 2001, Volume: 251, Issue: 5, Pages: 225-231 |
| ISSN: | 1433-8491 |
| DOI: | 10.1007/s004060170031 |
| Online Access: | Verlag, lizenzpflichtig, Volltext: https://doi.org/10.1007/s004060170031
|
| Author Notes: | M. Jauss, K. Herholz, L. Kracht, J. Pantel, T. Hartmann, M. Jensen, M. Essig, J. Schröder |
MARC
| LEADER | 00000caa a2200000 c 4500 | ||
|---|---|---|---|
| 001 | 1745560483 | ||
| 003 | DE-627 | ||
| 005 | 20230426074304.0 | ||
| 007 | cr uuu---uuuuu | ||
| 008 | 210125s2001 xx |||||o 00| ||eng c | ||
| 024 | 7 | |a 10.1007/s004060170031 |2 doi | |
| 035 | |a (DE-627)1745560483 | ||
| 035 | |a (DE-599)KXP1745560483 | ||
| 035 | |a (OCoLC)1341389326 | ||
| 040 | |a DE-627 |b ger |c DE-627 |e rda | ||
| 041 | |a eng | ||
| 084 | |a 33 |2 sdnb | ||
| 100 | 1 | |a Jauß, Jan Marek |d 1962- |e VerfasserIn |0 (DE-588)113067542 |0 (DE-627)393087255 |0 (DE-576)16937551X |4 aut | |
| 245 | 1 | 0 | |a Frontotemporal dementia |b clinical, neuroimaging, and molecular biological findings in 6 patients |c M. Jauss, K. Herholz, L. Kracht, J. Pantel, T. Hartmann, M. Jensen, M. Essig, J. Schröder |
| 264 | 1 | |c October 2001 | |
| 300 | |a 7 | ||
| 336 | |a Text |b txt |2 rdacontent | ||
| 337 | |a Computermedien |b c |2 rdamedia | ||
| 338 | |a Online-Ressource |b cr |2 rdacarrier | ||
| 500 | |a Gesehen am 25.01.2021 | ||
| 520 | |a Establishing the diagnosis in patients with clinical signs and symptoms suggesting primary degenerative disease with marked frontal lobe involvement is difficult. Neuroimaging methods, in particular positron emission tomography (PET) with the tracer 18fluoro-2-deoxyglucose (FDG) and cerebrospinal fluid (CSF) examination of β-amyloid and tau-protein levels may give additional information. We report five patients with clinical and radiological features of degenerative dementia with predominantly frontal involvement and one patient with primary progressive aphasia Diagnostic work-up included computed tomography (CT), magnetic resonance imaging (MRI), PET and tau-protein and β-amyloid level determination in CSF. While neuropsychological performance varied among patients, CT and MRI demonstrated persistently frontal lobe involvement. PET revealed corresponding changes with frontal hypometabolism, but in addition, four patients (among them two with no corresponding temporal changes in CT or MRI) showed a decreased glucose uptake in the temporal cortices. CSF samples from five patients revealed elevated β-amyloid 1-42 and tau levels in three and two patients, respectively. Reduced β-amyloid 1-40 was found in two patients. We conclude that occurrence of clinical symptoms of frontotemporal dementia is accompanied by frontal hypometabolism regardless of additional clinical findings. The value of determination of β-amyloid and tau protein levels remains to be determined. | ||
| 700 | 1 | |a Herholz, K. |e VerfasserIn |4 aut | |
| 700 | 1 | |a Kracht, L. |e VerfasserIn |4 aut | |
| 700 | 1 | |a Pantel, Johannes |d 1963- |e VerfasserIn |0 (DE-588)113067526 |0 (DE-627)588317039 |0 (DE-576)301323305 |4 aut | |
| 700 | 1 | |a Hartmann, Tobias |e VerfasserIn |0 (DE-588)108240022X |0 (DE-627)84746007X |0 (DE-576)455405824 |4 aut | |
| 700 | 1 | |a Jensen, M. |e VerfasserIn |4 aut | |
| 700 | 1 | |a Essig, Marco |e VerfasserIn |0 (DE-588)1048464490 |0 (DE-627)780470605 |0 (DE-576)172458595 |4 aut | |
| 700 | 1 | |a Schröder, Johannes |d 1957- |e VerfasserIn |0 (DE-588)138708517 |0 (DE-627)605263469 |0 (DE-576)308769848 |4 aut | |
| 773 | 0 | 8 | |i Enthalten in |t European archives of psychiatry and clinical neuroscience |d Darmstadt : Steinkopff, 1868 |g 251(2001), 5, Seite 225-231 |h Online-Ressource |w (DE-627)253722691 |w (DE-600)1459045-1 |w (DE-576)072372559 |x 1433-8491 |7 nnas |a Frontotemporal dementia clinical, neuroimaging, and molecular biological findings in 6 patients |
| 773 | 1 | 8 | |g volume:251 |g year:2001 |g number:5 |g pages:225-231 |g extent:7 |a Frontotemporal dementia clinical, neuroimaging, and molecular biological findings in 6 patients |
| 856 | 4 | 0 | |u https://doi.org/10.1007/s004060170031 |x Verlag |x Resolving-System |z lizenzpflichtig |3 Volltext |
| 951 | |a AR | ||
| 992 | |a 20210125 | ||
| 993 | |a Article | ||
| 994 | |a 2001 | ||
| 998 | |g 138708517 |a Schröder, Johannes |m 138708517:Schröder, Johannes |d 910000 |d 910600 |e 910000PS138708517 |e 910600PS138708517 |k 0/910000/ |k 1/910000/910600/ |p 8 |y j | ||
| 998 | |g 1048464490 |a Essig, Marco |m 1048464490:Essig, Marco |d 50000 |e 50000PE1048464490 |k 0/50000/ |p 7 | ||
| 998 | |g 108240022X |a Hartmann, Tobias |m 108240022X:Hartmann, Tobias |d 700000 |d 706000 |e 700000PH108240022X |e 706000PH108240022X |k 0/700000/ |k 1/700000/706000/ |p 5 | ||
| 998 | |g 113067526 |a Pantel, Johannes |m 113067526:Pantel, Johannes |d 910000 |d 910600 |e 910000PP113067526 |e 910600PP113067526 |k 0/910000/ |k 1/910000/910600/ |p 4 | ||
| 998 | |g 113067542 |a Jauß, Jan Marek |m 113067542:Jauß, Jan Marek |p 1 |x j | ||
| 999 | |a KXP-PPN1745560483 |e 3841874029 | ||
| BIB | |a Y | ||
| SER | |a journal | ||
| JSO | |a {"title":[{"title_sort":"Frontotemporal dementia","title":"Frontotemporal dementia","subtitle":"clinical, neuroimaging, and molecular biological findings in 6 patients"}],"language":["eng"],"id":{"doi":["10.1007/s004060170031"],"eki":["1745560483"]},"physDesc":[{"extent":"7 S."}],"relHost":[{"pubHistory":["1.1868/69 -"],"title":[{"title_sort":"European archives of psychiatry and clinical neuroscience","title":"European archives of psychiatry and clinical neuroscience"}],"part":{"text":"251(2001), 5, Seite 225-231","year":"2001","volume":"251","extent":"7","pages":"225-231","issue":"5"},"language":["eng"],"recId":"253722691","origin":[{"publisherPlace":"Darmstadt ; Berlin ; Heidelberg","dateIssuedKey":"1868","dateIssuedDisp":"1868-","publisher":"Steinkopff ; Springer"}],"type":{"bibl":"periodical","media":"Online-Ressource"},"titleAlt":[{"title":"Psychiatry and clinical neuroscience"},{"title":"Archiv für Psychiatrie und Nervenkrankheiten"},{"title":"European archives of psychiatry and neurological sciences"}],"physDesc":[{"extent":"Online-Ressource"}],"disp":"Frontotemporal dementia clinical, neuroimaging, and molecular biological findings in 6 patientsEuropean archives of psychiatry and clinical neuroscience","id":{"eki":["253722691"],"zdb":["1459045-1"],"issn":["1433-8491"]},"note":["Zusatz teils: official organ of the German Society for Biological Psychiatry","Ungezählte Beil.: Supplement"]}],"note":["Gesehen am 25.01.2021"],"recId":"1745560483","origin":[{"dateIssuedKey":"2001","dateIssuedDisp":"October 2001"}],"type":{"bibl":"article-journal","media":"Online-Ressource"},"person":[{"display":"Jauß, Jan Marek","given":"Jan Marek","role":"aut","family":"Jauß"},{"role":"aut","given":"K.","display":"Herholz, K.","family":"Herholz"},{"given":"L.","role":"aut","display":"Kracht, L.","family":"Kracht"},{"given":"Johannes","role":"aut","display":"Pantel, Johannes","family":"Pantel"},{"family":"Hartmann","role":"aut","given":"Tobias","display":"Hartmann, Tobias"},{"display":"Jensen, M.","role":"aut","given":"M.","family":"Jensen"},{"family":"Essig","display":"Essig, Marco","role":"aut","given":"Marco"},{"family":"Schröder","role":"aut","given":"Johannes","display":"Schröder, Johannes"}],"name":{"displayForm":["M. Jauss, K. Herholz, L. Kracht, J. Pantel, T. Hartmann, M. Jensen, M. Essig, J. Schröder"]}} | ||
| SRT | |a JAUSSJANMAFRONTOTEMP2001 | ||