The effects of co-prescription of pantoprazole on the clozapine metabolism
BACKGROUND: Polypharmacy including somatic medications such as proton pump inhibitors is a common phenomenon in psychiatric care. The aim of this study was to evaluate the pantoprazole effects on clozapine metabolism. METHODS: A large therapeutic drug-monitoring database containing plasma concentrat...
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| Main Authors: | , , , , , , |
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| Format: | Article (Journal) |
| Language: | English |
| Published: |
2020
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| In: |
Pharmacopsychiatry
Year: 2020, Volume: 53, Issue: 2, Pages: 65-70 |
| ISSN: | 1439-0795 |
| DOI: | 10.1055/a-1021-8827 |
| Online Access: | Verlag, lizenzpflichtig, Volltext: https://doi.org/10.1055/a-1021-8827 Verlag, lizenzpflichtig, Volltext: https://www.thieme-connect.com/products/ejournals/abstract/10.1055/a-1021-8827 
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| Author Notes: | Maxim Kuzin, Georgios Schoretsanitis, Ekkehard Haen, Gerhard Dammann, Christoph Hiemke, Gerhard Gründer, Michael Paulzen |
MARC
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| 245 | 1 | 4 | |a The effects of co-prescription of pantoprazole on the clozapine metabolism |c Maxim Kuzin, Georgios Schoretsanitis, Ekkehard Haen, Gerhard Dammann, Christoph Hiemke, Gerhard Gründer, Michael Paulzen |
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| 520 | |a BACKGROUND: Polypharmacy including somatic medications such as proton pump inhibitors is a common phenomenon in psychiatric care. The aim of this study was to evaluate the pantoprazole effects on clozapine metabolism. METHODS: A large therapeutic drug-monitoring database containing plasma concentrations of CLZ was analyzed. The results were stratified into four groups: a non-smoking (n=250) and a smoking group (n=326), and two groups co-medicated with pantoprazole: non-smokers (n=26) and smokers (n=29). The analysis was based on the non-parametrical Mann-Whitney U test (M-W-U) with a significance level of 0.05. RESULTS: Differences reached statistical significance for pharmacokinetic parameters between CLZ monotherapy and co-medication with pantoprazole neither in smokers nor in non-smokers (p>0.05 for M-W-U in pairwise comparisons). In patients with clozapine monotherapy, smokers had a higher daily dosage of CLZ compared to non-smokers (mean dosage 363±181 vs. 291±145 mg/day, p<0.001 for M-W-U). CONCLUSIONS: Adding pantoprazole to an ongoing treatment with clozapine does not alter the metabolism of clozapine to a significant extent. | ||
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