D2 dopamine receptor up-regulation, treatment response, neurological soft signs, and extrapyramidal side effects in schizophrenia: a follow-up study with 123I-Iodobenzamide single photon emission computed tomography in the drug-naive state and after neuroleptic treatment
Background: Animal and postmortem studies indicate that neuroleptic therapy may induce D2 dopamine receptor up-regulation in the basal ganglia. Methods: To address this phenomenon in a clinical study, we investigated the D2 dopamine receptor binding in 15 DSM-III-R schizophrenics in the drug-naive s...
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| Hauptverfasser: | , , , , , , , |
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| Dokumenttyp: | Article (Journal) |
| Sprache: | Englisch |
| Veröffentlicht: |
20 July 1998
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| In: |
Biological psychiatry
Year: 1998, Jahrgang: 43, Heft: 9, Pages: 660-665 |
| ISSN: | 1873-2402 |
| DOI: | 10.1016/S0006-3223(97)00442-3 |
| Online-Zugang: | Verlag, lizenzpflichtig, Volltext: https://doi.org/10.1016/S0006-3223(97)00442-3 Verlag, lizenzpflichtig, Volltext: http://www.sciencedirect.com/science/article/pii/S0006322397004423 
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| Verfasserangaben: | Johannes Schröder, Simone Silvestri, Bernd Bubeck, Markus Karr, Sibylle Demisch, Sabine Scherrer, Franz J Geider, Heinrich Sauer |
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| 245 | 1 | 0 | |a D2 dopamine receptor up-regulation, treatment response, neurological soft signs, and extrapyramidal side effects in schizophrenia |b a follow-up study with 123I-Iodobenzamide single photon emission computed tomography in the drug-naive state and after neuroleptic treatment |c Johannes Schröder, Simone Silvestri, Bernd Bubeck, Markus Karr, Sibylle Demisch, Sabine Scherrer, Franz J Geider, Heinrich Sauer |
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| 520 | |a Background: Animal and postmortem studies indicate that neuroleptic therapy may induce D2 dopamine receptor up-regulation in the basal ganglia. Methods: To address this phenomenon in a clinical study, we investigated the D2 dopamine receptor binding in 15 DSM-III-R schizophrenics in the drug-naive state and 3 days after completion of a standardized neuroleptic therapy (benperidol 12-16 mg/day, for 25 days) using single photon emission computed tomography (SPECT). SPECT scans were obtained 2 hours after intravenous injection of 185 MBq 123I-iodobenzamide. For analysis, basal ganglia to frontal cortex (BG/FC) ratios were calculated and the patient sample was subgrouped into patients with a favorable versus a poor treatment response. Results: Neuroleptic treatment led to decreased BG/FC ratios in patients with a favorable response, but increased ratios in the poor responders (df = 1, F = 4.1, p = .06). Changes of BG/FC ratios were significantly correlated with extrapyramidal side effects but not with neurological soft signs. Conclusions: Our findings suggest that neuroleptic therapy may induce D2 dopamine receptor up-regulation in a subgroup of patients characterized by poor treatment response and pronounced extrapyramidal side effects. | ||
| 650 | 4 | |a D dopamine receptor up-regulation | |
| 650 | 4 | |a extrapyramidal side effects | |
| 650 | 4 | |a neurological soft signs | |
| 650 | 4 | |a Schizophrenia | |
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| 650 | 4 | |a treatment response | |
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