Insights into cancer severity from biomolecular interaction mechanisms
To attain a deeper understanding of diseases like cancer, it is critical to couple genetics with biomolecular mechanisms. High-throughput sequencing has identified thousands of somatic mutations across dozens of cancers, and there is a pressing need to identify the few that are pathologically releva...
Saved in:
| Main Authors: | , , , , |
|---|---|
| Format: | Article (Journal) |
| Language: | English |
| Published: |
04 October 2016
|
| In: |
Scientific reports
Year: 2016, Volume: 6 |
| ISSN: | 2045-2322 |
| DOI: | 10.1038/srep34490 |
| Online Access: | Verlag, lizenzpflichtig, Volltext: https://doi.org/10.1038/srep34490 Verlag, lizenzpflichtig, Volltext: https://www.nature.com/articles/srep34490 |
| Author Notes: | Francesco Raimondi, Gurdeep Singh, Matthew J. Betts, Gordana Apic, Ranka Vukotic, Pietro Andreone, Lincoln Stein & Robert B. Russell |
MARC
| LEADER | 00000caa a2200000 c 4500 | ||
|---|---|---|---|
| 001 | 1745703810 | ||
| 003 | DE-627 | ||
| 005 | 20230426064727.0 | ||
| 007 | cr uuu---uuuuu | ||
| 008 | 210126s2016 xx |||||o 00| ||eng c | ||
| 024 | 7 | |a 10.1038/srep34490 |2 doi | |
| 035 | |a (DE-627)1745703810 | ||
| 035 | |a (DE-599)KXP1745703810 | ||
| 035 | |a (OCoLC)1341389616 | ||
| 040 | |a DE-627 |b ger |c DE-627 |e rda | ||
| 041 | |a eng | ||
| 084 | |a 32 |2 sdnb | ||
| 100 | 1 | |a Raimondi, Francesco |e VerfasserIn |0 (DE-588)1166616355 |0 (DE-627)1030514046 |0 (DE-576)510825575 |4 aut | |
| 245 | 1 | 0 | |a Insights into cancer severity from biomolecular interaction mechanisms |c Francesco Raimondi, Gurdeep Singh, Matthew J. Betts, Gordana Apic, Ranka Vukotic, Pietro Andreone, Lincoln Stein & Robert B. Russell |
| 264 | 1 | |c 04 October 2016 | |
| 300 | |a 10 | ||
| 336 | |a Text |b txt |2 rdacontent | ||
| 337 | |a Computermedien |b c |2 rdamedia | ||
| 338 | |a Online-Ressource |b cr |2 rdacarrier | ||
| 500 | |a Gesehen am 17.02.2021 | ||
| 520 | |a To attain a deeper understanding of diseases like cancer, it is critical to couple genetics with biomolecular mechanisms. High-throughput sequencing has identified thousands of somatic mutations across dozens of cancers, and there is a pressing need to identify the few that are pathologically relevant. Here we use protein structure and interaction data to interrogate nonsynonymous somatic cancer mutations, identifying a set of 213 molecular interfaces (protein-protein, -small molecule or -nucleic acid) most often perturbed in cancer, highlighting several potentially novel cancer genes. Over half of these interfaces involve protein-small-molecule interactions highlighting their overall importance in cancer. We found distinct differences in the predominance of perturbed interfaces between cancers and histological subtypes and presence or absence of certain interfaces appears to correlate with cancer severity. | ||
| 700 | 1 | |a Singh, Gurdeep |d 1990- |e VerfasserIn |0 (DE-588)1195739354 |0 (DE-627)167780937X |4 aut | |
| 700 | 1 | |a Betts, Matthew J. |e VerfasserIn |0 (DE-588)1050283740 |0 (DE-627)78378127X |0 (DE-576)404498930 |4 aut | |
| 700 | 1 | |a Apic, Gordana |e VerfasserIn |0 (DE-588)116045499X |0 (DE-627)1023632608 |0 (DE-576)505902982 |4 aut | |
| 700 | 1 | |a Russell, Robert B. |e VerfasserIn |0 (DE-588)173751091 |0 (DE-627)698656334 |0 (DE-576)134591755 |4 aut | |
| 773 | 0 | 8 | |i Enthalten in |t Scientific reports |d [London] : Springer Nature, 2011 |g 6(2016) Artikel-Nummer 34490, 10 Seiten |h Online-Ressource |w (DE-627)663366712 |w (DE-600)2615211-3 |w (DE-576)346641179 |x 2045-2322 |7 nnas |a Insights into cancer severity from biomolecular interaction mechanisms |
| 773 | 1 | 8 | |g volume:6 |g year:2016 |g extent:10 |a Insights into cancer severity from biomolecular interaction mechanisms |
| 856 | 4 | 0 | |u https://doi.org/10.1038/srep34490 |x Verlag |x Resolving-System |z lizenzpflichtig |3 Volltext |
| 856 | 4 | 0 | |u https://www.nature.com/articles/srep34490 |x Verlag |z lizenzpflichtig |3 Volltext |
| 951 | |a AR | ||
| 992 | |a 20210126 | ||
| 993 | |a Article | ||
| 994 | |a 2016 | ||
| 998 | |g 173751091 |a Russell, Robert B. |m 173751091:Russell, Robert B. |d 700000 |d 716000 |d 140000 |e 700000PR173751091 |e 716000PR173751091 |e 140000PR173751091 |k 0/700000/ |k 1/700000/716000/ |k 0/140000/ |p 8 |y j | ||
| 998 | |g 116045499X |a Apic, Gordana |m 116045499X:Apic, Gordana |d 700000 |d 718000 |e 700000PA116045499X |e 718000PA116045499X |k 0/700000/ |k 1/700000/718000/ |p 4 | ||
| 998 | |g 1050283740 |a Betts, Matthew J. |m 1050283740:Betts, Matthew J. |d 700000 |d 718000 |e 700000PB1050283740 |e 718000PB1050283740 |k 0/700000/ |k 1/700000/718000/ |p 3 | ||
| 998 | |g 1195739354 |a Singh, Gurdeep |m 1195739354:Singh, Gurdeep |d 700000 |d 718000 |e 700000PS1195739354 |e 718000PS1195739354 |k 0/700000/ |k 1/700000/718000/ |p 2 | ||
| 998 | |g 1166616355 |a Raimondi, Francesco |m 1166616355:Raimondi, Francesco |d 700000 |d 716000 |e 700000PR1166616355 |e 716000PR1166616355 |k 0/700000/ |k 1/700000/716000/ |p 1 |x j | ||
| 999 | |a KXP-PPN1745703810 |e 3842538804 | ||
| BIB | |a Y | ||
| SER | |a journal | ||
| JSO | |a {"person":[{"given":"Francesco","family":"Raimondi","role":"aut","roleDisplay":"VerfasserIn","display":"Raimondi, Francesco"},{"role":"aut","display":"Singh, Gurdeep","roleDisplay":"VerfasserIn","given":"Gurdeep","family":"Singh"},{"display":"Betts, Matthew J.","roleDisplay":"VerfasserIn","role":"aut","family":"Betts","given":"Matthew J."},{"given":"Gordana","family":"Apic","role":"aut","display":"Apic, Gordana","roleDisplay":"VerfasserIn"},{"roleDisplay":"VerfasserIn","display":"Russell, Robert B.","role":"aut","family":"Russell","given":"Robert B."}],"title":[{"title_sort":"Insights into cancer severity from biomolecular interaction mechanisms","title":"Insights into cancer severity from biomolecular interaction mechanisms"}],"recId":"1745703810","language":["eng"],"type":{"media":"Online-Ressource","bibl":"article-journal"},"note":["Gesehen am 17.02.2021"],"name":{"displayForm":["Francesco Raimondi, Gurdeep Singh, Matthew J. Betts, Gordana Apic, Ranka Vukotic, Pietro Andreone, Lincoln Stein & Robert B. Russell"]},"id":{"doi":["10.1038/srep34490"],"eki":["1745703810"]},"origin":[{"dateIssuedDisp":"04 October 2016","dateIssuedKey":"2016"}],"relHost":[{"disp":"Insights into cancer severity from biomolecular interaction mechanismsScientific reports","note":["Gesehen am 12.07.24"],"type":{"media":"Online-Ressource","bibl":"periodical"},"language":["eng"],"recId":"663366712","pubHistory":["1, article number 1 (2011)-"],"part":{"year":"2016","extent":"10","volume":"6","text":"6(2016) Artikel-Nummer 34490, 10 Seiten"},"title":[{"title":"Scientific reports","title_sort":"Scientific reports"}],"physDesc":[{"extent":"Online-Ressource"}],"origin":[{"publisher":"Springer Nature ; Nature Publishing Group","dateIssuedKey":"2011","dateIssuedDisp":"2011-","publisherPlace":"[London] ; London"}],"id":{"eki":["663366712"],"zdb":["2615211-3"],"issn":["2045-2322"]}}],"physDesc":[{"extent":"10 S."}]} | ||
| SRT | |a RAIMONDIFRINSIGHTSIN0420 | ||