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Analysis of body mass index, weight loss and progression of idiopathic pulmonary fibrosis

Nintedanib is an approved therapy for idiopathic pulmonary fibrosis (IPF). Some patients treated with nintedanib experience weight loss. Exploratory data suggest that low body mass index or weight loss are associated with worse outcomes in patients with IPF. We investigated whether BMI at baseline o...

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Hauptverfasser: Jouneau, Stéphane (VerfasserIn) , Crestani, Bruno (VerfasserIn) , Thibault, Ronan (VerfasserIn) , Lederlin, Mathieu (VerfasserIn) , Vernhet, Laurent (VerfasserIn) , Valenzuela, Claudia (VerfasserIn) , Wijsenbeek, Marlies (VerfasserIn) , Kreuter, Michael (VerfasserIn) , Stansen, Wibke (VerfasserIn) , Quaresma, Manuel (VerfasserIn) , Cottin, Vincent (VerfasserIn)
Dokumenttyp: Article (Journal)
Sprache:Englisch
Veröffentlicht: 25 November 2020
In: Respiratory research
Year: 2020, Jahrgang: 21
ISSN:1465-993X
DOI:10.1186/s12931-020-01528-4
Online-Zugang:Verlag, lizenzpflichtig, Volltext: https://doi.org/10.1186/s12931-020-01528-4
Verlag, lizenzpflichtig, Volltext: https://respiratory-research.biomedcentral.com/articles/10.1186/s12931-020-01528-4
Volltext
Verfasserangaben:Stéphane Jouneau, Bruno Crestani, Ronan Thibault, Mathieu Lederlin, Laurent Vernhet, Claudia Valenzuela, Marlies Wijsenbeek, Michael Kreuter, Wibke Stansen, Manuel Quaresma and Vincent Cottin

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520 |a Nintedanib is an approved therapy for idiopathic pulmonary fibrosis (IPF). Some patients treated with nintedanib experience weight loss. Exploratory data suggest that low body mass index or weight loss are associated with worse outcomes in patients with IPF. We investigated whether BMI at baseline or weight loss over 52 weeks was associated with FVC decline, or influenced the effect of nintedanib, in patients with IPF. 
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