FGF2 and IL-1β - explorers of unconventional secretory pathways at a glance
Skip to Next Section - Fibroblast growth factor 2 (FGF2) and interleukin 1β (IL-1β) were among the earliest examples of a subclass of proteins with extracellular functions that were found to lack N-terminal secretory signal peptides and were shown to be secreted in an ER- and Golgi-independent manne...
Saved in:
| Main Authors: | , |
|---|---|
| Format: | Article (Journal) |
| Language: | English |
| Published: |
November 5, 2020
|
| In: |
Journal of cell science
Year: 2020, Volume: 133, Issue: 21, Pages: 1-7 |
| ISSN: | 1477-9137 |
| DOI: | 10.1242/jcs.250449 |
| Online Access: | Verlag, lizenzpflichtig, Volltext: https://doi.org/10.1242/jcs.250449 Verlag, lizenzpflichtig, Volltext: https://jcs.biologists.org/content/133/21/jcs250449 
|
| Author Notes: | Maria Teresa Pallotta and Walter Nickel |
| Summary: | Skip to Next Section - Fibroblast growth factor 2 (FGF2) and interleukin 1β (IL-1β) were among the earliest examples of a subclass of proteins with extracellular functions that were found to lack N-terminal secretory signal peptides and were shown to be secreted in an ER- and Golgi-independent manner. Many years later, a number of alternative secretory pathways have been discovered, processes collectively termed unconventional protein secretion (UPS). In the course of these studies, unconventional secretion of FGF2 and IL-1β were found to be based upon distinct pathways, mechanisms and molecular machineries. Following a concise introduction into various pathways mediating unconventional secretion and transcellular spreading of proteins, this Cell Science at a Glance poster article aims at a focused analysis of recent key discoveries providing unprecedented detail about the molecular mechanisms and machineries driving FGF2 and IL-1β secretion. These findings are also highly relevant for other unconventionally secreted cargoes that, like FGF2 and IL1β, exert fundamental biological functions in biomedically relevant processes, such as tumor-induced angiogenesis and inflammation. |
|---|---|
| Item Description: | Gesehen am 27.01.2021 |
| Physical Description: | Online Resource |
| ISSN: | 1477-9137 |
| DOI: | 10.1242/jcs.250449 |