Imidazole propionate is increased in diabetes and associated with dietary patterns and altered microbial ecology
Microbiota-host-diet interactions contribute to the development of metabolic diseases. Imidazole propionate is a novel microbially produced metabolite from histidine, which impairs glucose metabolism. Here, we show that subjects with prediabetes and diabetes in the MetaCardis cohort from three Europ...
Saved in:
| Main Authors: | , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , |
|---|---|
| Format: | Article (Journal) |
| Language: | English |
| Published: |
18 November 2020
|
| In: |
Nature Communications
Year: 2020, Volume: 11 |
| ISSN: | 2041-1723 |
| DOI: | 10.1038/s41467-020-19589-w |
| Online Access: | Verlag, lizenzpflichtig, Volltext: https://doi.org/10.1038/s41467-020-19589-w Verlag, lizenzpflichtig, Volltext: https://www.nature.com/articles/s41467-020-19589-w 
|
| Author Notes: | Antonio Molinaro et al. |
MARC
| LEADER | 00000caa a2200000 c 4500 | ||
|---|---|---|---|
| 001 | 1745983481 | ||
| 003 | DE-627 | ||
| 005 | 20241229021115.0 | ||
| 007 | cr uuu---uuuuu | ||
| 008 | 210129s2020 xx |||||o 00| ||eng c | ||
| 024 | 7 | |a 10.1038/s41467-020-19589-w |2 doi | |
| 035 | |a (DE-627)1745983481 | ||
| 035 | |a (DE-599)KXP1745983481 | ||
| 035 | |a (OCoLC)1341389761 | ||
| 040 | |a DE-627 |b ger |c DE-627 |e rda | ||
| 041 | |a eng | ||
| 084 | |a 32 |2 sdnb | ||
| 100 | 1 | |a Molinaro, Antonio |e VerfasserIn |0 (DE-588)1225938813 |0 (DE-627)1745983767 |4 aut | |
| 245 | 1 | 0 | |a Imidazole propionate is increased in diabetes and associated with dietary patterns and altered microbial ecology |c Antonio Molinaro et al. |
| 264 | 1 | |c 18 November 2020 | |
| 300 | |a 10 | ||
| 336 | |a Text |b txt |2 rdacontent | ||
| 337 | |a Computermedien |b c |2 rdamedia | ||
| 338 | |a Online-Ressource |b cr |2 rdacarrier | ||
| 500 | |a Antonio Molinaro, Pierre Bel Lassen, Marcus Henricsson, Hao Wu, Solia Adriouch, Eugeni Belda, Rima Chakaroun, Trine Nielsen, Per-Olof Bergh, Christine Rouault, Sébastien André, Florian Marquet, Fabrizio Andreelli, Joe-Elie Salem, Karen Assmann, Jean-Philippe Bastard, Sofia Forslund, Emmanuelle Le Chatelier, Gwen Falony, Nicolas Pons, Edi Prifti, Benoit Quinquis, Hugo Roume, Sara Vieira-Silva, Tue H. Hansen, Helle Krogh Pedersen, Christian Lewinter, Nadja B. Sønderskov, Lars Køber, Henrik Vestergaard, Torben Hansen, Jean-Daniel Zucker, Pilar Galan, Marc-Emmanuel Dumas, Jeroen Raes, Jean-Michel Oppert, Ivica Letunic, Jens Nielsen, Peer Bork, S. Dusko Ehrlich, Michael Stumvoll, Oluf Pedersen, Judith Aron-Wisnewsky, Karine Clément & Fredrik Bäckhed | ||
| 500 | |a Gesehen am 29.01.2021 | ||
| 520 | |a Microbiota-host-diet interactions contribute to the development of metabolic diseases. Imidazole propionate is a novel microbially produced metabolite from histidine, which impairs glucose metabolism. Here, we show that subjects with prediabetes and diabetes in the MetaCardis cohort from three European countries have elevated serum imidazole propionate levels. Furthermore, imidazole propionate levels were increased in subjects with low bacterial gene richness and Bacteroides 2 enterotype, which have previously been associated with obesity. The Bacteroides 2 enterotype was also associated with increased abundance of the genes involved in imidazole propionate biosynthesis from dietary histidine. Since patients and controls did not differ in their histidine dietary intake, the elevated levels of imidazole propionate in type 2 diabetes likely reflects altered microbial metabolism of histidine, rather than histidine intake per se. Thus the microbiota may contribute to type 2 diabetes by generating imidazole propionate that can modulate host inflammation and metabolism. | ||
| 700 | 1 | |a Bel Lassen, Pierre |e VerfasserIn |4 aut | |
| 700 | 1 | |a Henricsson, Marcus |e VerfasserIn |4 aut | |
| 700 | 1 | |a Wu, Hao |e VerfasserIn |4 aut | |
| 700 | 1 | |a Adriouch, Solia |e VerfasserIn |4 aut | |
| 700 | 1 | |a Belda, Eugeni |e VerfasserIn |4 aut | |
| 700 | 1 | |a Chakaroun, Rima |e VerfasserIn |4 aut | |
| 700 | 1 | |a Nielsen, Trine |e VerfasserIn |4 aut | |
| 700 | 1 | |a Bergh, Per-Olof |e VerfasserIn |4 aut | |
| 700 | 1 | |a Rouault, Christine |e VerfasserIn |4 aut | |
| 700 | 1 | |a André, Sébastien |e VerfasserIn |4 aut | |
| 700 | 1 | |a Marquet, Florian |e VerfasserIn |4 aut | |
| 700 | 1 | |a Andreelli, Fabrizio |e VerfasserIn |4 aut | |
| 700 | 1 | |a Salem, Joe-Elie |e VerfasserIn |4 aut | |
| 700 | 1 | |a Assmann, Karen |e VerfasserIn |4 aut | |
| 700 | 1 | |a Bastard, Jean-Philippe |e VerfasserIn |4 aut | |
| 700 | 1 | |a Forslund, Sofia |e VerfasserIn |4 aut | |
| 700 | 1 | |a Le Chatelier, Emmanuelle |e VerfasserIn |4 aut | |
| 700 | 1 | |a Falony, Gwen |e VerfasserIn |4 aut | |
| 700 | 1 | |a Pons, Nicolas |e VerfasserIn |4 aut | |
| 700 | 1 | |a Prifti, Edi |e VerfasserIn |4 aut | |
| 700 | 1 | |a Quinquis, Benoit |e VerfasserIn |4 aut | |
| 700 | 1 | |a Roume, Hugo |e VerfasserIn |4 aut | |
| 700 | 1 | |8 1\p |a Vieira-Silva, Sara |e VerfasserIn |0 (DE-588)1256776750 |0 (DE-627)1800857683 |4 aut | |
| 700 | 1 | |a Hansen, Tue H. |e VerfasserIn |4 aut | |
| 700 | 1 | |a Pedersen, Helle Krogh |e VerfasserIn |4 aut | |
| 700 | 1 | |a Lewinter, Christian |e VerfasserIn |4 aut | |
| 700 | 1 | |a Sønderskov, Nadja B. |e VerfasserIn |4 aut | |
| 700 | 1 | |a Køber, Lars |e VerfasserIn |4 aut | |
| 700 | 1 | |a Vestergaard, Henrik |e VerfasserIn |4 aut | |
| 700 | 1 | |a Hansen, Torben |e VerfasserIn |4 aut | |
| 700 | 1 | |a Zucker, Jean-Daniel |e VerfasserIn |4 aut | |
| 700 | 1 | |a Galan, Pilar |e VerfasserIn |4 aut | |
| 700 | 1 | |a Dumas, Marc-Emmanuel |e VerfasserIn |4 aut | |
| 700 | 1 | |a Raes, Jeroen |e VerfasserIn |4 aut | |
| 700 | 1 | |a Oppert, Jean-Michel |e VerfasserIn |4 aut | |
| 700 | 1 | |a Letunic, Ivica |e VerfasserIn |4 aut | |
| 700 | 1 | |8 2\p |a Nielsen, Jens |d 1962- |e VerfasserIn |0 (DE-588)1132083109 |0 (DE-627)887357482 |0 (DE-576)488600936 |4 aut | |
| 700 | 1 | |a Bork, Peer |d 1963- |e VerfasserIn |0 (DE-588)122539117 |0 (DE-627)705944476 |0 (DE-576)293313946 |4 aut | |
| 700 | 1 | |a Ehrlich, S. Dusko |e VerfasserIn |4 aut | |
| 700 | 1 | |a Stumvoll, Michael |e VerfasserIn |4 aut | |
| 700 | 1 | |8 3\p |a Pedersen, Oluf |e VerfasserIn |0 (DE-588)1261088506 |0 (DE-627)1880871769 |4 aut | |
| 700 | 1 | |a Aron-Wisnewsky, Judith |e VerfasserIn |4 aut | |
| 700 | 1 | |a Clément, Karine |e VerfasserIn |4 aut | |
| 700 | 1 | |a Bäckhed, Fredrik |e VerfasserIn |4 aut | |
| 773 | 0 | 8 | |i Enthalten in |t Nature Communications |d [London] : Springer Nature, 2010 |g 11(2020) Artikel-Nummer 5881, 10 Seiten |h Online-Ressource |w (DE-627)626457688 |w (DE-600)2553671-0 |w (DE-576)331555905 |x 2041-1723 |7 nnas |a Imidazole propionate is increased in diabetes and associated with dietary patterns and altered microbial ecology |
| 773 | 1 | 8 | |g volume:11 |g year:2020 |g extent:10 |a Imidazole propionate is increased in diabetes and associated with dietary patterns and altered microbial ecology |
| 856 | 4 | 0 | |u https://doi.org/10.1038/s41467-020-19589-w |x Verlag |x Resolving-System |z lizenzpflichtig |3 Volltext |
| 856 | 4 | 0 | |u https://www.nature.com/articles/s41467-020-19589-w |x Verlag |z lizenzpflichtig |3 Volltext |
| 883 | |8 1\p |a cgwrk |d 20241001 |q DE-101 |u https://d-nb.info/provenance/plan#cgwrk | ||
| 883 | |8 2\p |a cgwrk |d 20241001 |q DE-101 |u https://d-nb.info/provenance/plan#cgwrk | ||
| 883 | |8 3\p |a cgwrk |d 20241001 |q DE-101 |u https://d-nb.info/provenance/plan#cgwrk | ||
| 951 | |a AR | ||
| 992 | |a 20210129 | ||
| 993 | |a Article | ||
| 994 | |a 2020 | ||
| 998 | |g 122539117 |a Bork, Peer |m 122539117:Bork, Peer |d 140000 |e 140000PB122539117 |k 0/140000/ |p 39 | ||
| 999 | |a KXP-PPN1745983481 |e 3844408177 | ||
| BIB | |a Y | ||
| SER | |a journal | ||
| JSO | |a {"type":{"bibl":"article-journal","media":"Online-Ressource"},"recId":"1745983481","note":["Antonio Molinaro, Pierre Bel Lassen, Marcus Henricsson, Hao Wu, Solia Adriouch, Eugeni Belda, Rima Chakaroun, Trine Nielsen, Per-Olof Bergh, Christine Rouault, Sébastien André, Florian Marquet, Fabrizio Andreelli, Joe-Elie Salem, Karen Assmann, Jean-Philippe Bastard, Sofia Forslund, Emmanuelle Le Chatelier, Gwen Falony, Nicolas Pons, Edi Prifti, Benoit Quinquis, Hugo Roume, Sara Vieira-Silva, Tue H. Hansen, Helle Krogh Pedersen, Christian Lewinter, Nadja B. Sønderskov, Lars Køber, Henrik Vestergaard, Torben Hansen, Jean-Daniel Zucker, Pilar Galan, Marc-Emmanuel Dumas, Jeroen Raes, Jean-Michel Oppert, Ivica Letunic, Jens Nielsen, Peer Bork, S. Dusko Ehrlich, Michael Stumvoll, Oluf Pedersen, Judith Aron-Wisnewsky, Karine Clément & Fredrik Bäckhed","Gesehen am 29.01.2021"],"relHost":[{"id":{"issn":["2041-1723"],"zdb":["2553671-0"],"eki":["626457688"]},"note":["Gesehen am 13.06.24"],"part":{"text":"11(2020) Artikel-Nummer 5881, 10 Seiten","year":"2020","extent":"10","volume":"11"},"recId":"626457688","pubHistory":["2010-"],"type":{"bibl":"periodical","media":"Online-Ressource"},"title":[{"title_sort":"Nature Communications","title":"Nature Communications"}],"origin":[{"publisher":"Springer Nature ; Nature Publishing Group UK","dateIssuedDisp":"[2010]-","publisherPlace":"[London] ; [London]"}],"physDesc":[{"extent":"Online-Ressource"}],"disp":"Imidazole propionate is increased in diabetes and associated with dietary patterns and altered microbial ecologyNature Communications","language":["eng"]}],"name":{"displayForm":["Antonio Molinaro et al."]},"id":{"doi":["10.1038/s41467-020-19589-w"],"eki":["1745983481"]},"origin":[{"dateIssuedKey":"2020","dateIssuedDisp":"18 November 2020"}],"physDesc":[{"extent":"10 S."}],"language":["eng"],"person":[{"display":"Molinaro, Antonio","roleDisplay":"VerfasserIn","role":"aut","given":"Antonio","family":"Molinaro"},{"family":"Bel Lassen","display":"Bel Lassen, Pierre","given":"Pierre","roleDisplay":"VerfasserIn","role":"aut"},{"family":"Henricsson","given":"Marcus","role":"aut","roleDisplay":"VerfasserIn","display":"Henricsson, Marcus"},{"family":"Wu","display":"Wu, Hao","given":"Hao","roleDisplay":"VerfasserIn","role":"aut"},{"given":"Solia","roleDisplay":"VerfasserIn","role":"aut","display":"Adriouch, Solia","family":"Adriouch"},{"family":"Belda","display":"Belda, Eugeni","roleDisplay":"VerfasserIn","role":"aut","given":"Eugeni"},{"family":"Chakaroun","given":"Rima","roleDisplay":"VerfasserIn","role":"aut","display":"Chakaroun, Rima"},{"roleDisplay":"VerfasserIn","role":"aut","given":"Trine","display":"Nielsen, Trine","family":"Nielsen"},{"role":"aut","roleDisplay":"VerfasserIn","given":"Per-Olof","display":"Bergh, Per-Olof","family":"Bergh"},{"family":"Rouault","given":"Christine","roleDisplay":"VerfasserIn","role":"aut","display":"Rouault, Christine"},{"family":"André","display":"André, Sébastien","roleDisplay":"VerfasserIn","role":"aut","given":"Sébastien"},{"family":"Marquet","role":"aut","roleDisplay":"VerfasserIn","given":"Florian","display":"Marquet, Florian"},{"display":"Andreelli, Fabrizio","given":"Fabrizio","roleDisplay":"VerfasserIn","role":"aut","family":"Andreelli"},{"family":"Salem","display":"Salem, Joe-Elie","given":"Joe-Elie","role":"aut","roleDisplay":"VerfasserIn"},{"family":"Assmann","given":"Karen","role":"aut","roleDisplay":"VerfasserIn","display":"Assmann, Karen"},{"display":"Bastard, Jean-Philippe","given":"Jean-Philippe","role":"aut","roleDisplay":"VerfasserIn","family":"Bastard"},{"display":"Forslund, Sofia","given":"Sofia","roleDisplay":"VerfasserIn","role":"aut","family":"Forslund"},{"display":"Le Chatelier, Emmanuelle","role":"aut","roleDisplay":"VerfasserIn","given":"Emmanuelle","family":"Le Chatelier"},{"family":"Falony","given":"Gwen","roleDisplay":"VerfasserIn","role":"aut","display":"Falony, Gwen"},{"family":"Pons","role":"aut","roleDisplay":"VerfasserIn","given":"Nicolas","display":"Pons, Nicolas"},{"given":"Edi","role":"aut","roleDisplay":"VerfasserIn","display":"Prifti, Edi","family":"Prifti"},{"family":"Quinquis","given":"Benoit","roleDisplay":"VerfasserIn","role":"aut","display":"Quinquis, Benoit"},{"given":"Hugo","role":"aut","roleDisplay":"VerfasserIn","display":"Roume, Hugo","family":"Roume"},{"display":"Vieira-Silva, Sara","given":"Sara","roleDisplay":"VerfasserIn","role":"aut","family":"Vieira-Silva"},{"family":"Hansen","given":"Tue H.","roleDisplay":"VerfasserIn","role":"aut","display":"Hansen, Tue H."},{"family":"Pedersen","display":"Pedersen, Helle Krogh","roleDisplay":"VerfasserIn","role":"aut","given":"Helle Krogh"},{"display":"Lewinter, Christian","given":"Christian","role":"aut","roleDisplay":"VerfasserIn","family":"Lewinter"},{"display":"Sønderskov, Nadja B.","roleDisplay":"VerfasserIn","role":"aut","given":"Nadja B.","family":"Sønderskov"},{"family":"Køber","given":"Lars","role":"aut","roleDisplay":"VerfasserIn","display":"Køber, Lars"},{"given":"Henrik","role":"aut","roleDisplay":"VerfasserIn","display":"Vestergaard, Henrik","family":"Vestergaard"},{"family":"Hansen","given":"Torben","role":"aut","roleDisplay":"VerfasserIn","display":"Hansen, Torben"},{"family":"Zucker","role":"aut","roleDisplay":"VerfasserIn","given":"Jean-Daniel","display":"Zucker, Jean-Daniel"},{"family":"Galan","roleDisplay":"VerfasserIn","role":"aut","given":"Pilar","display":"Galan, Pilar"},{"family":"Dumas","roleDisplay":"VerfasserIn","role":"aut","given":"Marc-Emmanuel","display":"Dumas, Marc-Emmanuel"},{"given":"Jeroen","roleDisplay":"VerfasserIn","role":"aut","display":"Raes, Jeroen","family":"Raes"},{"display":"Oppert, Jean-Michel","given":"Jean-Michel","role":"aut","roleDisplay":"VerfasserIn","family":"Oppert"},{"display":"Letunic, Ivica","given":"Ivica","role":"aut","roleDisplay":"VerfasserIn","family":"Letunic"},{"family":"Nielsen","display":"Nielsen, Jens","given":"Jens","roleDisplay":"VerfasserIn","role":"aut"},{"family":"Bork","display":"Bork, Peer","given":"Peer","roleDisplay":"VerfasserIn","role":"aut"},{"display":"Ehrlich, S. Dusko","role":"aut","roleDisplay":"VerfasserIn","given":"S. Dusko","family":"Ehrlich"},{"family":"Stumvoll","display":"Stumvoll, Michael","given":"Michael","roleDisplay":"VerfasserIn","role":"aut"},{"display":"Pedersen, Oluf","roleDisplay":"VerfasserIn","role":"aut","given":"Oluf","family":"Pedersen"},{"family":"Aron-Wisnewsky","given":"Judith","roleDisplay":"VerfasserIn","role":"aut","display":"Aron-Wisnewsky, Judith"},{"roleDisplay":"VerfasserIn","role":"aut","given":"Karine","display":"Clément, Karine","family":"Clément"},{"display":"Bäckhed, Fredrik","given":"Fredrik","roleDisplay":"VerfasserIn","role":"aut","family":"Bäckhed"}],"title":[{"title":"Imidazole propionate is increased in diabetes and associated with dietary patterns and altered microbial ecology","title_sort":"Imidazole propionate is increased in diabetes and associated with dietary patterns and altered microbial ecology"}]} | ||
| SRT | |a MOLINAROANIMIDAZOLEP1820 | ||