Radical cystectomy under continuous antiplatelet therapy with acetylsalicylic acid
Introduction - Aim of this study was to analyse the perioperative outcome of patients undergoing radical cystectomy under continuous antiplatelet therapy with acetylsalicylic acid. - Materials and methods - Using prospectively maintained databases of two departments of urology, we identified 461 con...
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| Main Authors: | , , , , , , , , , |
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| Format: | Article (Journal) |
| Language: | English |
| Published: |
22 February 2019
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| In: |
European journal of surgical oncology
Year: 2019, Volume: 45, Issue: 7, Pages: 1260-1265 |
| ISSN: | 1532-2157 |
| DOI: | 10.1016/j.ejso.2019.02.023 |
| Online Access: | Verlag, lizenzpflichtig, Volltext: https://doi.org/10.1016/j.ejso.2019.02.023 Verlag, lizenzpflichtig, Volltext: http://www.sciencedirect.com/science/article/pii/S074879831930294X 
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| Author Notes: | F. Wessels, M.C. Kriegmair, A. Oehme, M.C. Rassweiler-Seyfried, P. Erben, R. Oberneder, M. Kriegmair, M. Ritter, M.S. Michel, P. Honeck |
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| 520 | |a Introduction - Aim of this study was to analyse the perioperative outcome of patients undergoing radical cystectomy under continuous antiplatelet therapy with acetylsalicylic acid. - Materials and methods - Using prospectively maintained databases of two departments of urology, we identified 461 consecutive patients who underwent radical cystectomy for bladder cancer (2011-2017). Patients were divided into three groups: 1) on-going antiplatelet therapy with acetylsalicylic acid (n=50), 2) discontinuing antiplatelet therapy (n=65) and 3) no antiplatelet therapy (n=346). Perioperative outcome was compared between the three groups using ANOVA, likelihood ratio or Kruskal Wallis test with post-hoc testing. Uni- and multivariate analyses were performed to identify predictor for perioperative complications and transfusion. - Results - Group 1 showed an average estimated blood loss of 732±424, group 2 752±488 and group 3 810±544ml (p=0.51). There was no significant difference in transfusion rate (44% in group 1, 45% and 39% in groups 2 and 3, p=0.63). Severe complications occurred in 26%, 15% and 15% in groups 1-3 (p=0.19). Ischemic complications were more often observed in group 1 (n=4, 8%) and 2 (n=5, 8%) than group 3 (n=7, 2%), p=0.02. 90-day readmission (n=99, 22%) and mortality rate (n=10, 2.2%) were low and did not show any significant differences between the groups. In uni- and multivariate analysis ongoing therapy with acetylsalicylic acid was no independent risk factor for transfusion or severe complications. - Conclusion - Perioperative continuation of therapy with acetylsalicylic acid in radical cystectomy is safe with no difference in intraoperative blood loss, transfusion rate, complications or mortality. | ||
| 650 | 4 | |a Acetylsalicylic acid | |
| 650 | 4 | |a Antiplatelet | |
| 650 | 4 | |a Aspirin | |
| 650 | 4 | |a Bladder cancer | |
| 650 | 4 | |a Cystectomy | |
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